Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Wioleta Marut"'
Autor:
Sandra C. Silva-Cardoso, Weiyang Tao, Chiara Angiolilli, Ana P. Lopes, Cornelis P. J. Bekker, Abhinandan Devaprasad, Barbara Giovannone, Jaap van Laar, Marta Cossu, Wioleta Marut, Erik Hack, Rob J. de Boer, Marianne Boes, Timothy R. D. J. Radstake, Aridaman Pandit
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Fibrosis is a condition shared by numerous inflammatory diseases. Our incomplete understanding of the molecular mechanisms underlying fibrosis has severely hampered effective drug development. CXCL4 is associated with the onset and extent of fibrosis
Externí odkaz:
https://doaj.org/article/e286df9b07224ea08dc328f58bd71e1b
Autor:
Tiago Carvalheiro, Samuel Garcia, M. Inês Pascoal Ramos, Barbara Giovannone, Timothy R. D. J. Radstake, Wioleta Marut, Linde Meyaard
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has co
Externí odkaz:
https://doaj.org/article/aa256f731a47437d9eeeab8d62c8e41f
Autor:
Tiago Carvalheiro, Ana P. Lopes, Maarten van der Kroef, Beatriz Malvar-Fernandez, Carlos Rafael-Vidal, Anneline C. Hinrichs, Nila H. Servaas, Femke Bonte-Mineur, Marc R. Kok, Lorenzo Beretta, Maili Zimmermann, Wioleta Marut, Jose M. Pego-Reigosa, Timothy R. D. J. Radstake, Samuel Garcia
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9544 (2020)
Angiopoietin-2 (Ang-2), a ligand of the tyrosine kinase receptor Tie2, is essential for vascular development and blood vessel stability and is also involved in monocyte activation. Here, we examined the role of Ang-2 on monocyte activation in patient
Externí odkaz:
https://doaj.org/article/d20f2409f26e4b589add05d5ec117d02
Autor:
Tiago Carvalheiro, Wioleta Marut, M. Inês Pascoal Ramos, Samuel García, Devan Fleury, Alsya J. Affandi, Aniek S. Meijers, Barbara Giovannone, Ralph G. Tieland, Eline Elshof, Andrea Ottria, Marta Cossu, Matthew L. Meizlish, Tineke Veenendaal, Meera Ramanujam, Miguel E. Moreno-García, Judith Klumperman, Nalan Liv, Timothy R.D.J. Radstake, Linde Meyaard
SummaryTissue repair is disturbed in fibrotic diseases like systemic sclerosis (SSc), where the deposition of large amounts of extracellular matrix components such as collagen interferes with organ function. LAIR-1 is an inhibitory collagen receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be816d427ea40a4f319d28194692d26
https://doi.org/10.1101/2021.12.07.471103
https://doi.org/10.1101/2021.12.07.471103
Autor:
Kris A. Reedquist, Andrea Ottria, Wioleta Marut, Beatriz Malvar Fernandez, Timothy R D J Radstake, Samuel Garcia, Barbara Giovannone, Tiago Carvalheiro
Publikováno v:
Rheumatology (Oxford, England)
Objectives SSc is an autoimmune disease characterized by inflammation, vascular injury and excessive fibrosis in multiple organs. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that regulates processes involved i
Autor:
Timothy R D J Radstake, Chiara Angiolilli, Maarten van der Kroef, Kris A. Reedquist, Wioleta Marut, Eleni Chouri
Publikováno v:
Nature Reviews Rheumatology. 14:657-673
Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular abnormalities, immunological alterations and fibrosis of the skin and internal organs. The results of genetic studies in patients with SSc have revealed statist
Autor:
Wioleta Marut, Tiago Carvalheiro, Femke Bonte-Mineur, Jose M Pego-Reigosa, Beatriz Malvar-Fernandez, Carlos Rafael-Vidal, Timothy R D J Radstake, Maili Zimmermann, Maarten van der Kroef, Lorenzo Beretta, Samuel Garcia, Anneline C Hinrichs, Marc R. Kok, Ana P Lopes, Nila H. Servaas
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9544, p 9544 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences
Volume 21
Issue 24
Angiopoietin-2 (Ang-2), a ligand of the tyrosine kinase receptor Tie2, is essential for vascular development and blood vessel stability and is also involved in monocyte activation. Here, we examined the role of Ang-2 on monocyte activation in patient
Autor:
Alsya J. Affandi, Tiago Carvalheiro, Andrea Ottria, Judith J. de Haan, Maike A.D. Brans, Maarten M. Brandt, Ralph G. Tieland, Ana P. Lopes, Beatriz Malvar Fernández, Cornelis P.J. Bekker, Maarten van der Linden, Maili Zimmermann, Barbara Giovannone, Catharina G.K. Wichers, Samuel Garcia, Michael de Kok, Giuseppina Stifano, Yan Juan Xu, M. Anna Kowalska, Maaike Waasdorp, Caroline Cheng, Susan Gibbs, Saskia C.A. de Jager, Joel A.G. van Roon, Timothy R.D.J. Radstake, Wioleta Marut
Publikováno v:
Cell Reports, 38(1):110189. Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernandez, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Cell Reports, 38(1). Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernández, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernandez, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Cell Reports, 38(1). Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernández, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic disease in which CXCL4 is increased and strongly correlates with sk
Autor:
Marta Cossu, Abhinandan Devaprasad, Chiara Angiolilli, Trdj Radstake, Erik C Hack, Sandra C Silva-Cardoso, de Boer Rj, Cornelis P. J. Bekker, Wioleta Marut, Weiyang Tao, Aridaman Pandit, Marianne Boes, Ana P Lopes, van Laar J, Barbara Giovannone
Fibrosis is a condition shared by numerous inflammatory diseases. Our incomplete understanding of the molecular mechanisms underlying fibrosis has severely hampered effective drug development. CXCL4 is associated with the onset and extent of fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0425c141d59b1814bf91759c070b00b5
https://doi.org/10.1101/807230
https://doi.org/10.1101/807230
Autor:
Wioleta Marut, Femke Wolters, Joel A G van Roon, Lorenzo Beretta, Sandra C Silva-Cardoso, Catharina G.K. Wichers, Jacob M van Laar, Soley Thordardottir, Cornelis P. J. Bekker, Eleni Chouri, Marta Cossu, Lenny van Bon, Kris A. Reedquist, Javier Martín, Maarten van der Kroef, Alsya J. Affandi, Lara Bossini-Castillo, Jasper C A Broen, Timothy R D J Radstake, Frederique M Moret, Marzia Rossato, Harry Dolstra
Publikováno v:
Arthritis & Rheumatology. 69:1891-1902
OBJECTIVE: Plasmacytoid dendritic cells (PDCs) are a critical source of type I interferons (IFNs) that can contribute to the onset and maintenance of autoimmunity. Molecular mechanisms leading to PDC dysregulation and a persistent type I IFN signatur