Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Wioleta Grabowska"'
1
Akademický článek
Optimized RT-qPCR and a novel normalization method for validating circulating miRNA biomarkers in ageing-related diseases
Autor: Andrew Want, Karolina Staniak, Wioleta Grabowska-Pyrzewicz, Aleksandra Fesiuk, Anna Barczak, Tomasz Gabryelewicz, Agnieszka Kulczyńska-Przybik, Barbara Mroczko, Urszula Wojda
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Circulating miRNAs have potential as minimally invasive biomarkers for diagnosing various diseases, including ageing-related disorders such as Alzheimer’s disease (AD). However, the lack of standardization in the common analysis method, RT
Externí odkaz: https://doaj.org/article/aee6d7077508426092283d6fd5bba37a
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3
Akademický článek
Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
Autor: Wioleta Grabowska-Pyrzewicz, Andrew Want, Jerzy Leszek, Urszula Wojda
Publikováno v: EBioMedicine, Vol 74, Iss , Pp 103691- (2021)
Alzheimer's disease (AD) represents a particular therapeutic challenge because its aetiology is very complex, with dynamic progression from preclinical to clinical stages. Several potential therapeutic targets and strategies were tested for AD, in ov
Externí odkaz: https://doaj.org/article/a829b7ada1024b9f994e0a86a7acb583
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4
Novel Dicarboximide BK124.1 Breaks Multidrug Resistance and Shows Anticancer Efficacy in Chronic Myeloid Leukemia Preclinical Models and Patients' CD34
Autor: Iga, Stukan, Marek, Gryzik, Grażyna, Hoser, Andrew, Want, Wioleta, Grabowska-Pyrzewicz, Mikolaj, Zdioruk, Mariola, Napiórkowska, Marcin, Cieślak, Karolina, Królewska-Golińska, Barbara, Nawrot, Grzegorz, Basak, Urszula, Wojda
Publikováno v: Cancers. 14(15)
The search is ongoing for new anticancer therapeutics that would overcome resistance to chemotherapy. This includes chronic myeloid leukemia, particularly suitable for the studies of novel anticancer compounds due to its homogenous and well-known gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78fc6c3828b619f620058765a15f1739
https://pubmed.ncbi.nlm.nih.gov/35892900
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5
Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
Autor: Jerzy Leszek, Andrew Want, Urszula Wojda, Wioleta Grabowska-Pyrzewicz
Publikováno v: EBioMedicine
EBioMedicine, Vol 74, Iss, Pp 103691-(2021)
Alzheimer's disease (AD) represents a particular therapeutic challenge because its aetiology is very complex, with dynamic progression from preclinical to clinical stages. Several potential therapeutic targets and strategies were tested for AD, in ov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29cce4e1140f2066726bcb229d5e3c7
http://europepmc.org/articles/PMC8602003
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6
Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence
Autor: Natalia Achtabowska, Grazyna Mosieniak, Robert Czochara, Ewa Sikora, Anna Bielak-Zmijewska, Wioleta Grabowska, Grzegorz Litwinienko, Agnieszka Bojko
Publikováno v: Biogerontology
Curcumin, a phytochemical present in the spice named turmeric, and one of the promising anti-aging factors, is itself able to induce cellular senescence. We have recently shown that cells building the vasculature senesced as a result of curcumin trea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4100da5b2c0327a7c1d084b5558af45
https://doi.org/10.1007/s10522-019-09825-2
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7
Rapha Myr
Autor: Barbara, Tomasello, Maria Domenica, Di Mauro, Giuseppe Antonio, Malfa, Rosaria, Acquaviva, Fulvia, Sinatra, Giorgia, Spampinato, Samuele, Laudani, Giusy, Villaggio, Anna, Bielak-Zmijewska, Wioleta, Grabowska, Ignazio Alberto, Barbagallo, Maria Teresa, Liuzzo, Elisabetta, Sbisà, Maria Grazia, Forte, Claudia, Di Giacomo, Massimo, Bonucci, Marcella, Renis
Publikováno v: International Journal of Molecular Sciences
Brain and other nervous system cancers are the 10th leading cause of death worldwide. Genome instability, cell cycle deregulation, epigenetic mechanisms, cytoarchitecture disassembly, redox homeostasis as well as apoptosis are involved in carcinogene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a26398d3574c6bd21bf942b0d75746ab
https://pubmed.ncbi.nlm.nih.gov/32727075
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8
Sirtuins, a promising target in slowing down the ageing process
Autor: Ewa Sikora, Anna Bielak-Zmijewska, Wioleta Grabowska
Publikováno v: Biogerontology
Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or even prevent some age-related pathologies. There are some defined interventions, which give promis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54295abb96ba10ecbb8447edc86466a
https://doi.org/10.1007/s10522-017-9685-9
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9
Rapha Myr(R), a Blend of Sulforaphane and Myrosinase, Exerts Antitumor and Anoikis-Sensitizing Effects on Human Astrocytoma Cells Modulating Sirtuins and DNA Methylation
Autor: Rosaria Acquaviva, Giuseppe Antonio Malfa, Massimo Bonucci, Barbara Tomasello, Marcella Renis, Elisabetta Sbisà, Wioleta Grabowska, Ignazio Barbagallo, Maria Grazia Forte, Samuele Laudani, Anna Bielak-Zmijewska, Giorgia Spampinato, Fulvia Sinatra, Giusy Villaggio, Claudia Di Giacomo, Maria Domenica Di Mauro, Maria Teresa Liuzzo
Publikováno v: International journal of molecular sciences (Online) 21 (2020). doi:10.3390/ijms21155328
info:cnr-pdr/source/autori:Tomasello, Barbara; Di Mauro, Maria Domenica; Malfa, Giuseppe Antonio; Acquaviva, Rosaria; Sinatra, Fulvia; Spampinato, Giorgia; Laudani, Samuele; Villaggio, Giusy; Bielak-Zmijewska, Anna; Grabowska, Wioleta; Barbagallo, Ignazio Alberto; Liuzzo, Maria Teresa; Sbisa', Elisabetta; Forte, Maria Grazia; Di Giacomo, Claudia; Bonucci, Massimo; Renis, Marcella/titolo:Rapha Myr(R), a Blend of Sulforaphane and Myrosinase, Exerts Antitumor and Anoikis-Sensitizing Effects on Human Astrocytoma Cells Modulating Sirtuins and DNA Methylation/doi:10.3390%2Fijms21155328/rivista:International journal of molecular sciences (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:21
International Journal of Molecular Sciences, Vol 21, Iss 5328, p 5328 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 15
Brain and other nervous system cancers are the 10th leading cause of death worldwide. Genome instability, cell cycle deregulation, epigenetic mechanisms, cytoarchitecture disassembly, redox homeostasis as well as apoptosis are involved in carcinogene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db7532c00dfdf02830cbdffb8f7dacd
http://www.cnr.it/prodotto/i/448120
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10
IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells
Autor: Agata Klejman, Anna Bielak-Zmijewska, Krzysztof Skowronek, Natalia Achtabowska, Wioleta Grabowska, Malgorzata Calka
Publikováno v: Mechanisms of ageing and development. 190
Cell senescence - an irreversible proliferation arrest - is one of the possible cellular responses to stress. There is a vast variety of stimuli, extrinsic and intrinsic, known to induce senescence, and several molecular pathways involved in the proc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b3601e515f5011fba7a337e4cc14c9
https://pubmed.ncbi.nlm.nih.gov/32592713
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