The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control.

Autor: Kaur U; Department of Biochemistry & Molecular Biology, University of Massachusetts, Amherst, MA 01003., Kihn KC; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201., Ke H; Department of Biochemistry & Molecular Biology, University of Massachusetts, Amherst, MA 01003., Kuo W; Department of Biochemistry & Molecular Biology, University of Massachusetts, Amherst, MA 01003., Gierasch LM; Department of Biochemistry & Molecular Biology, University of Massachusetts, Amherst, MA 01003.; Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003.; Department of Chemistry, University of Massachusetts, Amherst, MA 01003., Hebert DN; Department of Biochemistry & Molecular Biology, University of Massachusetts, Amherst, MA 01003.; Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003., Wintrode PL; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201., Deredge D; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201., Gershenson A; Department of Biochemistry & Molecular Biology, University of Massachusetts, Amherst, MA 01003.; Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 26. Date of Electronic Publication: 2023 Apr 26.

Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts.

Autor: Chun H; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Kurasawa JH; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Olivares P; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Marakasova ES; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Shestopal SA; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Hassink GU; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Karnaukhova E; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Migliorini M; Center for Vascular and Inflammatory Diseases, Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Obi JO; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Smith AK; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Wintrode PL; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Durai P; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, Republic of Korea., Park K; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, Republic of Korea., Deredge D; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Strickland DK; Center for Vascular and Inflammatory Diseases, Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sarafanov AG; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2022 Oct; Vol. 20 (10), pp. 2255-2269. Date of Electronic Publication: 2022 Aug 04.

Common coding variant in SERPINA1 increases the risk for large artery stroke

Autor: Malik, R, Dau, T, Gonik, M, Sivakumar, A, Deredge, DJ, Edeleva, EV, Götzfried, J, Van Der Laan, SW, Pasterkamp, G, Beaufort, N, Seixas, S, Bevan, S, Lincz, LF, Holliday, EG, Burgess, AI, Rannikmäe, K, Minnerup, J, Kriebel, J, Waldenberger, M, Müller-Nurasyid, M, Lichtner, P, Saleheen, D, Woo, D, Debette, S, Maguire, J, Cole, JW, Majersik, J, Jimenez-Conde, J, Lee, JM, Rost, N, Pare, G, Jern, C, Lindgren, AG, Cardenas, IF, Rothwell, PM, Levi, C, Attia, J, Sudlow, CLM, Braun, D, Markus, HS, Wintrode, PL, Berger, K, Jenne, DE, Dichgans, M

Large artery atherosclerotic stroke (LAS) shows substantial heritability not explained by previous genome-wide association studies. Here, we explore the role of coding variation in LAS by analyzing variants on the HumanExome BeadChip in a total of 3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::329789ad945a533ee5eeba8d44ee5886
https://hdl.handle.net/10453/126735

Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.

Autor: Klontz EH; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Li C; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA., Kihn K; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, College Park, MD, 21201, USA., Fields JK; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Beckett D; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA., Snyder GA; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Wintrode PL; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, College Park, MD, 21201, USA., Deredge D; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, College Park, MD, 21201, USA., Wang LX; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA., Sundberg EJ; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. eric.sundberg@emory.edu.; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. eric.sundberg@emory.edu.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. eric.sundberg@emory.edu.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA. eric.sundberg@emory.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Dec 04; Vol. 11 (1), pp. 6204. Date of Electronic Publication: 2020 Dec 04.

A temperature-dependent conformational shift in p38α MAPK substrate-binding region associated with changes in substrate phosphorylation profile.

Autor: Deredge D; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201., Wintrode PL; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201., Tulapurkar ME; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201., Nagarsekar A; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201., Zhang Y; Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201., Weber DJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201., Shapiro P; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201., Hasday JD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201 jhasday@medicine.umaryland.edu.; Medicine and Research Services, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Aug 23; Vol. 294 (34), pp. 12624-12637. Date of Electronic Publication: 2019 Jun 18.