Mapping Differential Protein-Protein Interaction Networks using Affinity Purification Mass Spectrometry

Autor: Kaushal, Prashant, Ummadi, Manisha R., Jang, Gwendolyn M., Delgado, Yennifer, Makanani, Sara K., Blanc, Sophie F., Winters, Decan M., Xu, Jiewei, Polacco, Benjamin, Zhou, Yuan, Stevenson, Erica, Eckhardt, Manon, Zuliani-Alvarez, Lorena, Kaake, Robyn, Swaney, Danielle L., Krogan, Nevan, Bouhaddou, Mehdi

Proteins congregate into complexes to perform fundamental cellular functions. Phenotypic outcomes, in health and disease, are often mechanistically driven by the remodeling of protein complexes by protein coding mutations or cellular signaling change

Externí odkaz: http://arxiv.org/abs/2405.09699

Mapping Differential Protein-Protein Interaction Networks using Affinity Purification Mass Spectrometry.

Autor: Kaushal P; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.; Technical Contact., Ummadi MR; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Jang GM; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Delgado Y; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Makanani SK; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Blanc SF; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Winters DM; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Xu J; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Polacco B; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Zhou Y; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Stevenson E; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Eckhardt M; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Zuliani-Alvarez L; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Kaake R; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Swaney DL; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Krogan N; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; QBI Coronavirus Research Group (QCRG), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Bouhaddou M; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.; Technical Contact.; Lead Contact.

Publikováno v: ArXiv [ArXiv] 2024 May 15. Date of Electronic Publication: 2024 May 15.