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Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy.

Autor: Shahriyari M; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany., Islam MR; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany., Sakib SM; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany., Rinn M; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany., Rika A; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany., Krüger D; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany., Kaurani L; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany., Gisa V; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany., Winterhoff M; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany., Anandakumar H; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany., Shomroni O; NGS Integrative Genomics Core Unit, Institute of Human Genetics, University Medical Center Göttingen, Georg August University, Göttingen, Germany., Schmidt M; Department of Neurology, Neuromuscular Center, University Medical Center Göttingen, Georg August University, Göttingen, Germany., Salinas G; NGS Integrative Genomics Core Unit, Institute of Human Genetics, University Medical Center Göttingen, Georg August University, Göttingen, Germany., Unger A; Institute of Physiology II, University of Münster, Münster, Germany., Linke WA; Institute of Physiology II, University of Münster, Münster, Germany., Zschüntzsch J; Department of Neurology, Neuromuscular Center, University Medical Center Göttingen, Georg August University, Göttingen, Germany., Schmidt J; Department of Neurology, Neuromuscular Center, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; Department of Neurology and Pain Treatment, Immanuel Klinik Rüdersdorf, University Hospital of the Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Germany.; Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Germany., Bassel-Duby R; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Olson EN; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Fischer A; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany., Zimmermann WH; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Göttingen, Germany., Tiburcy M; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany.

Publikováno v: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2022 Dec; Vol. 13 (6), pp. 3106-3121. Date of Electronic Publication: 2022 Oct 18.

ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives.

Autor: Waqas SF; Research Group Biomarkers for Infectious Diseases, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany., Sohail A; Research Group Biomarkers for Infectious Diseases, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Current affiliation: Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Nguyen AHH; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Usman A; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Ludwig T; Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany., Wegner A; Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany., Malik MNH; Research Group Biomarkers for Infectious Diseases, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany., Schuchardt S; Department of Bio and Environmental Analytics, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany., Geffers R; Genome Analytics, Helmholtz-Centre for Infection Research, Braunschweig, Germany., Winterhoff M; Research Group Biomarkers for Infectious Diseases, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany., Merkert S; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Martin U; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Olmer R; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Lachmann N; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Pessler F; Research Group Biomarkers for Infectious Diseases, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Centre for Individualised Infection Medicine, Hannover, Germany.; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2022 Jul; Vol. 12 (7), pp. e931.

Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.

Autor: Sohail A; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Iqbal AA; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Sahini N; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Chen F; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Tantawy M; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Hormones Department, Medical Research and Clinical Studies Institute, National Research Center, Dokki, Giza, Egypt.; Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Center, Dokki, Giza, Egypt., Waqas SFH; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Winterhoff M; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Ebensen T; Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Schultz K; Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany., Geffers R; Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany., Schughart K; Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany.; University of Veterinary Medicine Hannover, Hannover, Germany.; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America., Preusse M; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany., Shehata M; Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany.; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Bähre H; Research Core Unit Metabolomics, Hannover Medical School, Hannover, Germany., Pils MC; Mouse Pathology Platform, Helmholtz Centre for Infection Research, Braunschweig, Germany., Guzman CA; Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Mostafa A; Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany.; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Pleschka S; Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany.; German Center for Infection Research (DZIF) partner site Giessen, Germany., Falk C; Department of Transplantation Immunology, Hannover Medical School, Hannover, Germany., Michelucci A; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Pessler F; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Centre for Individualised Infection Medicine, Hannover, Germany.

Publikováno v: PLoS pathogens [PLoS Pathog] 2022 Jan 13; Vol. 18 (1), pp. e1010219. Date of Electronic Publication: 2022 Jan 13 (Print Publication: 2022).

Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate.

Autor: Winterhoff M; TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany., Chen F; TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany., Sahini N; TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany., Ebensen T; Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany., Kuhn M; TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany., Kaever V; Research Core Unit Metabolomics, Hannover Medical School, 30625 Hannover, Germany., Bähre H; Research Core Unit Metabolomics, Hannover Medical School, 30625 Hannover, Germany., Pessler F; TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.; Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.; Centre for Individualised Infection Medicine, 30625 Hannover, Germany.

Publikováno v: Metabolites [Metabolites] 2021 Apr 26; Vol. 11 (5). Date of Electronic Publication: 2021 Apr 26.