Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity.

Autor: Verouti S; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; National Center of Competence in Research, Kidney.CH, Lausanne, Switzerland.; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Aeschlimann G; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Wang Q; Division of Nephrology and Hypertension, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Del Olmo DA; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Peyter AC; Neonatal Research Laboratory, Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Menétrey S; Neonatal Research Laboratory, Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Winter DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Pearce D; Department of Medicine and Cellular & Molecular Pharmacology, University of California, San Francisco, USA., Hummler E; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; National Center of Competence in Research, Kidney.CH, Lausanne, Switzerland., Vanderriele PE; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. Paulemmanuelvanderriele@gmail.com.; National Center of Competence in Research, Kidney.CH, Lausanne, Switzerland. Paulemmanuelvanderriele@gmail.com.

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Sep 10. Date of Electronic Publication: 2024 Sep 10.

Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb.

Autor: Lazaridis II; Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland.; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland., Bosch AJT; Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland.; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland., Keller L; Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland.; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland., Low AJY; Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland.; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland., Tamarelle J; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland., Moser SO; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Winter DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Gómez C; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Peterson CJ; Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland., Schneider R; Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland., Kraljević M; Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland., Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Vonaesch P; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland., Peterli R; Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland.; Department of Clinical Research, University of Basel, Basel, Switzerland., Delko T; Chirurgie Zentrum St. Anna, Lucerne, Switzerland., Cavelti-Weder C; Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland.; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland.; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2024 Jun 01; Vol. 326 (6), pp. E819-E831. Date of Electronic Publication: 2024 Apr 17.

Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase.

Autor: Jäger MC; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: m.jaeger@unibas.ch., Kędzierski J; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland; Division of Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 61, 4056 Basel, Switzerland. Electronic address: jacek.kedzierski@unibas.ch., Gell V; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland; Division of Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 61, 4056 Basel, Switzerland. Electronic address: victoria.gell@cup.uni-muenchen.de., Wey T; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: Tim.wey@protonmail.ch., Kollár J; Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria. Electronic address: jakub.kollar@pmu.ac.at., Winter DV; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: denise.winter@unibas.ch., Schuster D; Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria. Electronic address: daniela.schuster@pmu.ac.at., Smieško M; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland; Division of Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 61, 4056 Basel, Switzerland. Electronic address: martin.smiesko@unibas.ch., Odermatt A; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: alex.odermatt@unibas.ch.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 Sep 15; Vol. 475, pp. 116638. Date of Electronic Publication: 2023 Jul 26.

Calcineurin regulates aldosterone production via dephosphorylation of NFATC4.

Autor: Berber M; Institute of Anatomy, University of Zurich, Switzerland.; Swiss National Centre for Competence in Research 'Kidney Control of Homeostasis' (NCCR Kidney.CH), Zurich, Switzerland., Leng S; Department of Pediatrics, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA., Wengi A; Institute of Anatomy, University of Zurich, Switzerland., Winter DV; Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Odermatt A; Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Beuschlein F; Swiss National Centre for Competence in Research 'Kidney Control of Homeostasis' (NCCR Kidney.CH), Zurich, Switzerland.; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich and University of Zurich, Zurich, Switzerland.; Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany., Loffing J; Institute of Anatomy, University of Zurich, Switzerland.; Swiss National Centre for Competence in Research 'Kidney Control of Homeostasis' (NCCR Kidney.CH), Zurich, Switzerland., Breault DT; Department of Pediatrics, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA., Penton D; Institute of Anatomy, University of Zurich, Switzerland.; Swiss National Centre for Competence in Research 'Kidney Control of Homeostasis' (NCCR Kidney.CH), Zurich, Switzerland.

Publikováno v: JCI insight [JCI Insight] 2023 Jul 24; Vol. 8 (14). Date of Electronic Publication: 2023 Jul 24.

A novel mouse model for an inducible gene modification in the renal thick ascending limb.

Autor: Bourqui L; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Winter DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Loffing-Cueni D; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Loffing J; Institute of Anatomy, University of Zurich, Zurich, Switzerland.; National Centre of Competence in Research 'Kidney.CH', University of Zurich, Zurich, Switzerland.

Publikováno v: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2023 May 01; Vol. 324 (5), pp. F446-F460. Date of Electronic Publication: 2023 Mar 09.