Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain-A new treatment strategy for neonatal seizures?

Autor: Theilmann W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany., Brandt C; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany., Bohnhorst B; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Winstroth AM; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Das AM; Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany., Gramer M; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany., Kipper A; Institute for Organic Chemistry, Leibniz Universität Hannover, Hannover, Germany., Kalesse M; Institute for Organic Chemistry, Leibniz Universität Hannover, Hannover, Germany., Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany.; Center for Systems Neuroscience Hannover, Hannover, Germany.

Publikováno v: Epilepsia [Epilepsia] 2021 Jan; Vol. 62 (1), pp. 269-278. Date of Electronic Publication: 2020 Nov 02.