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CYP1A2 Activity as Measured by a Caffeine Test Predicts Clozapine and Active Metabolite Norclozapine Steady-State Concentration in Patients With Schizophrenia

Autor: Lawrence J. Albers, B. K. Tang, Rochelle Roy, Christopher Reist, Winston Walkes, Vural Özdemir, Werner Kalow, James L. Kennedy, Paul Posner, Pegah Afra, Evan J. Collins

Publikováno v: Journal of Clinical Psychopharmacology. 21:398-407

Clozapine is an atypical antipsychotic drug and displays efficacy in 30% to 60% of patients with schizophrenia who do not respond to traditional antipsychotics. A clozapine concentration greater than 1,150 nmol/L increases the probability of antipsyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f6fc71ce8db37c24876b296d1b3567
https://doi.org/10.1097/00004714-200108000-00007

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