Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Winston R, Becker"'
Autor:
Christoph Sadée, Lauren D. Hagler, Winston R. Becker, Inga Jarmoskaite, Pavanapuresan P. Vaidyanathan, Sarah K. Denny, William J. Greenleaf, Daniel Herschlag
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Traditional genomic methods identify RNA-binding proteins (RBPs) and the genes they regulate, but do not provide predictive models. The authors used an emerging technology to obtain a complete thermodynamic model for RNA binding to the PUF4 RBP.
Externí odkaz:
https://doaj.org/article/3ad3095b88be427a97f0f867b7311cf3
Autor:
Winston R. Becker, Stephanie A. Nevins, Derek C. Chen, Roxanne Chiu, Aaron M. Horning, Tuhin K. Guha, Rozelle Laquindanum, Meredith Mills, Hassan Chaib, Uri Ladabaum, Teri Longacre, Jeanne Shen, Edward D. Esplin, Anshul Kundaje, James M. Ford, Christina Curtis, Michael P. Snyder, William J. Greenleaf
Publikováno v:
Nature Genetics. 54:985-995
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ebd7e4dc9c72812eebbe5b1c9c92586
https://doi.org/10.1038/s41588-022-01088-x
https://doi.org/10.1038/s41588-022-01088-x
Autor:
Pavanapuresan P. Vaidyanathan, Inga Jarmoskaite, Winston R. Becker, Daniel Herschlag, William J. Greenleaf, Christoph Sadee, Lauren Hagler, Sarah K. Denny
Publikováno v:
Nature Communications. 13
Genomic methods have been valuable for identifying RNA-binding proteins (RBPs) and the genes, pathways, and processes they regulate. Nevertheless, standard motif descriptions cannot be used to predict all RNA targets or test quantitative models for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523b8e840dacdddd11ff07dd93565d80
https://doi.org/10.1038/s41467-022-31968-z
https://doi.org/10.1038/s41467-022-31968-z
Autor:
Marlene Rabinovitch, Angela J. Rogers, Madeline J. Lee, Nancy Q. Zhao, Samuel Yang, Catherine A. Blish, Bei Wei, Benjamin Parks, Ruoxi Pi, Ruth O'Hara, Winston R. Becker, Euan A. Ashley, Kari C. Nadeau, Giovanny J Martínez-Colón, Susan Holmes, Shalina Taylor, Aaron J. Wilk, Thanmayi Ranganath, David Jimenez-Morales, William J. Greenleaf, Andra L. Blomkalns, Stanford Covid Biobank
Publikováno v:
The Journal of Experimental Medicine
Single-cell profiling demonstrates multifarious dysregulation of innate immune phenotype associated with COVID-19 severity. Severe COVID-19 is associated with hyperactivation of neutrophils and NK cells, while monocytes take on tolerogenic phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bb8f81dd2003b249bebc03d738689e
https://doi.org/10.1084/jem.20210582
https://doi.org/10.1084/jem.20210582
Autor:
Pavanapuresan P. Vaidyanathan, William J. Greenleaf, Inga Jarmoskaite, Winston R. Becker, Daniel Herschlag
Publikováno v:
RNA
Posttranslational gene regulation requires a complex network of RNA–protein interactions. Cooperativity, which tunes response sensitivities, originates from protein–protein interactions in many systems. For RNA-binding proteins, cooperativity can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0700ae4d5dfc2515b04430f4103007f
https://doi.org/10.1261/rna.068585.118
https://doi.org/10.1261/rna.068585.118
Autor:
Meredith A. Mills, Tuhin Kumar Guha, Edward D. Esplin, Roxanne Chiu, Uri Ladabaum, Mathew Ellenberger, Teri A. Longacre, Samuel Lancaster, Aaron M. Horning, William J. Greenleaf, Stephanie A. Nevins, Lihua Jiang, Hayan Lee, Joanne Chan, Nasim Bararpour, Rozelle Laquindanum, James M. Ford, Ruiqi Jian, Michael Snyder, Aziz Khan, Jeanne Shen, Zheng Hu, D. Glen Esplin, Christina Curtis, Kévin Contrepois, Si Wu, Anshul Kundaje, Bahareh Bahmani, Basil Michael, Winston R. Becker, Casey Hanson, Hassan Chaib
Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected patients, leading to colorectal cancer (CRC), and is an ideal model to study early transition to CRC. We performed deep multi-omic profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::755d270fd4185a47d0f63029edbb710e
https://doi.org/10.21203/rs.3.rs-515393/v1
https://doi.org/10.21203/rs.3.rs-515393/v1
Autor:
Winston R, Becker, Stephanie A, Nevins, Derek C, Chen, Roxanne, Chiu, Aaron M, Horning, Tuhin K, Guha, Rozelle, Laquindanum, Meredith, Mills, Hassan, Chaib, Uri, Ladabaum, Teri, Longacre, Jeanne, Shen, Edward D, Esplin, Anshul, Kundaje, James M, Ford, Christina, Curtis, Michael P, Snyder, William J, Greenleaf
Publikováno v:
Nature genetics. 54(7)
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a0100db135dd60504215b34144c80e1
https://pubmed.ncbi.nlm.nih.gov/35778614
https://pubmed.ncbi.nlm.nih.gov/35778614
Autor:
Roxanne Chiu, Stephanie A. Nevins, Meredith A. Mills, Rozelle Laquindanum, Teri A. Longacre, Uri Ladabaum, Horning A, Edward D. Esplin, Christina Curtis, Derek Chen, Snyder M, Winston R. Becker, William J. Greenleaf, Jeanne Shen, Hassan Chaib, Anshul Kundaje, James M. Ford
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated 451,886 single-cell chromatin accessibility profiles and 208,557 single-cell tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::192fbfd182184ae9379f19095fea3f28
https://doi.org/10.1101/2021.03.24.436532
https://doi.org/10.1101/2021.03.24.436532
Autor:
Janice S. Chen, Hua B. Bai, Evan A. Boyle, Jennifer A. Doudna, Winston R. Becker, William J. Greenleaf
Publikováno v:
Science Advances
Science advances, vol 7, iss 8
Science advances, vol 7, iss 8
A massive new resource of diverse Cas9 binding and cleavage events establishes new rules for effective CRISPR targeting.
The RNA-guided nuclease Cas9 has unlocked powerful methods for perturbing both the genome through targeted DNA cleavage and
The RNA-guided nuclease Cas9 has unlocked powerful methods for perturbing both the genome through targeted DNA cleavage and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8277568d33823081661e9da228320a2d
https://doi.org/10.1126/sciadv.abe5496
https://doi.org/10.1126/sciadv.abe5496
Autor:
Benjamin Ober-Reynolds, Winston R. Becker, Karina Jouravleva, Samson M. Jolly, Phillip D. Zamore, William J. Greenleaf
Publikováno v:
Mol Cell
Argonautes are nucleic acid-guided proteins that perform numerous cellular functions across all domains of life. Little is known about how distinct evolutionary pressures have shaped each Argonaute's biophysical properties. We applied high-throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a6c38a0e5056ec93941fc85692dbcd
https://doi.org/10.1016/j.molcel.2022.02.026
https://doi.org/10.1016/j.molcel.2022.02.026