Výsledky vyhledávání - "Winston L. Hutchinson"

Immunoradiometric assay for human serum amyloid P component

Autor: David J. Millar, Mark B. Pepys, Winston L. Hutchinson

Publikováno v: Journal of Immunological Methods. 371:18-24

Human serum amyloid P component (SAP) is of increasing interest for its possible pathogenic role in amyloidosis and Alzheimer's disease, and as a therapeutic target in these conditions. We have developed and validated a robust and reproducible immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68092f0370bdcae876df94b61b45195f
https://doi.org/10.1016/j.jim.2011.06.010

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Antibodies to human serum amyloid P component eliminate visceral amyloid deposits

Publikováno v: Nature

Accumulation of amyloid fibrils in the viscera and connective tissues causes systemic amyloidosis, which is responsible for about one per thousand deaths in developed countries1. Localised amyloid can also be very serious, for example cerebral amyloi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3141ecfd1248ecef09d31ab84841df5
https://doi.org/10.1038/nature09494

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Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis

Autor: Philip N. Hawkins, Julian D. Gillmore, David J. Millar, Mark Offer, Aviva Petrie, Glenys A. Tennent, Helen J. Lachmann, Hugh J. B. Goodman, Winston L. Hutchinson, Janet Ruth Gallimore, Mark B. Pepys

Publikováno v: British Journal of Haematology. 148:760-767

Serum amyloid P component (SAP) is a universal constituent of amyloid deposits and contributes to their formation and/or persistence. We therefore developed CPHPC ((R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexa-noyl]pyrrolidine-2 carboxylic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d747141f5b3623811830f5a8b95c40a8
https://doi.org/10.1111/j.1365-2141.2009.08036.x

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Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice

Autor: J. Ruth Gallimore, G. Martin Benson, Amar P. Dhillon, Mark B. Pepys, Winston L. Hutchinson, Caroline A. Sabin, Glenys A. Tennent, Melvyn C. Kahan, Gideon M. Hirschfield

Publikováno v: Proceedings of the National Academy of Sciences. 102:8309-8314

The association between circulating concentrations of C-reactive protein (CRP) and future atherothrombotic events has provoked speculation about a possible pathogenetic role of CRP. However, we show here that transgenic expression of human CRP had no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fd60df265867aa50c59d5857452fdf
https://doi.org/10.1073/pnas.0503202102

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Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?

Autor: Winston L. Hutchinson, Ken Ichi Yamamura, Julian D. Gillmore, A Bybee, Daniel A. Mitchell, Robert P. Hasserjian, Mark B. Pepys, Misao Suzuki, Caroline A. Sabin, Jeff Herbert

Publikováno v: Immunology. 112:255-264

SUMMARY Human serum amyloid P component (SAP) binds avidly to DNA, chromatin and apoptotic cells in vitro and in vivo. 129/Sv 3 C57BL/6 mice with targeted deletion of the SAP gene spontaneously develop antinuclear autoantibodies and immune complex gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c8bb8109c00200110489c735fe9c17
https://doi.org/10.1111/j.1365-2567.2004.01860.x

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C-reactive protein is essential for innate resistance to pneumococcal infection

Autor: J Paul, Simons, Jutta M, Loeffler, Raya, Al-Shawi, Stephan, Ellmerich, Winston L, Hutchinson, Glenys A, Tennent, Aviva, Petrie, John G, Raynes, J Brian, de Souza, Rachel A, Lawrence, Kevin D, Read, Mark B, Pepys

Publikováno v: Immunology

No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known. Here we show for the first time that CRP-deficient mice are remarkably susceptible to Strep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0cb426f4043ee3f8c5dc5ff55240eb8
https://pubmed.ncbi.nlm.nih.gov/24673624

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Immunoradiometric Assay of Circulating C-Reactive Protein: Age-related Values in the Adult General Population

Autor: Wolfgang Koenig, Mark B. Pepys, Winston L. Hutchinson, Gordon D.O. Lowe, M. Sund, Margit Fröhlich

Publikováno v: Clinical Chemistry. 46:934-938

Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ef35dd95d4296e7b52b099a6087068f
https://doi.org/10.1093/clinchem/46.7.934

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Human Serum Amyloid P Component is a Single Uncomplexed Pentamer in Whole Serum

Autor: Mark B. Pepys, Erhard Hohenester, Winston L. Hutchinson

Publikováno v: Molecular Medicine. 6:482-493

Serum amyloid P component (SAP) is a universal constituent of amyloid deposits and contributes to their pathogenesis. SAP also has important normal functions in the handling of chromatin in vivo and resistance to bacterial infection. The atomic resol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e4290313837b4b4d4191568e72d0ecc
https://doi.org/10.1007/bf03401789

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