Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Winston C. Y. Yu"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Krüppel-like factor 10 (KLF10) is a phospho-regulated transcriptional factor involved in many biological processes including lipogenesis; however, the transcriptional regulation on lipogenesis by KLF10 remains largely unclear. Lipogenesis is importa
Externí odkaz:
https://doaj.org/article/acb021eaacfe4db3bedb7514e4572e27
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, Vol 8 (2021)
Krüppel-like factor 10 (KLF10) is a phospho-regulated transcriptional factor involved in many biological processes including lipogenesis; however, the transcriptional regulation on lipogenesis by KLF10 remains largely unclear. Lipogenesis is importa
Autor:
Vincent H.S. Chang, Yong Tzuo Lai, Liang Ti Huang, Min Ju Wu, Hsuen Wen Chang, Winston C Y Yu, Wen Chi Wu
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 79:231-238
KLF10 is a transforming growth factor (TGF)-β/Smad downstream regulated gene. KLF10 binds to the promoter of target genes and mimics the effects of TGF-β as a transcriptional factor. In our laboratory, we noted that Klf10 deficiency in mice is asso
Autor:
Yi-Rong Chen, Ching Hui Lin, Winston C Y Yu, Hung Shu Chang, Yuh-Jin Liang, Ming Shyen Yen, Chien Hui Yang, Chiung Ru Lai
Publikováno v:
International Journal of Cancer. 120:2377-2385
Immortalization is a critical event in virus-related oncogenesis. No enough information, however, is currently available to elucidate the changes that occur in cellular molecules during immortalization. To identify potential cellular markers or regul
Autor:
Ching-Hui Lin, Vincent H.S. Chang, Min-Ju Wu, Hsuen-Wen Chang, Yong-Tzuo Lai, Winston C Y Yu, Wen-Chi Wu
Publikováno v:
The international journal of biochemistrycell biology. 60
TGF-β plays a significant role in regulating pancreas islet function and maintaining their mass. KLF10, a TGF-β downstream gene, belongs to a group of Kruppel-like transcription factors that bind to the promoters of target genes and produce effects
Autor:
Czau-Siung Yang, Tsuey-Ying Hsu, Jen-Yang Chen, Winston C. Y. Yu, Ih-Jen Su, John Jenn-Yenn Lu
Publikováno v:
Journal of General Virology. 77:1883-1892
Epstein—Barr virus (EBV) induces human B cell transformation and is closely associated with naso-pharyngeal carcinoma. The expression of an EBV latent membrane protein, LMP-1, protects B cells from apoptosis by up-regulating the expression of a cel
Autor:
Frank S. Fan, Winston C. Y. Yu
Publikováno v:
Cancer Investigation. 13:280-286
Cells of a breast adenocarcinoma cell line, CAMA-IEe, were found to contain a moderate concentration of 1,25-dihydroxyvitamin D3[1,25(OH)2D3] receptors. The receptors' dissociation constant calculated by Scatchard analysis was 4.1 x 10(-10) M. These
Autor:
Diane H A Yang, Hung Shu Chang, Chia Ling Sui, Winston C Y Yu, Yu Chi Chen, Ching Fang Hsu, Jun Jie Wang, Wen Chi Wu
Publikováno v:
The international journal of biochemistrycell biology. 43(4)
Estrogen stimulates cell growth and inhibits apoptosis through estrogen receptor-mediated mechanisms in many cell types. Remarkably, there is another dimension to estrogen action by which apoptosis is induced in breast cancer cells. While these mecha
Publikováno v:
The international journal of biochemistrycell biology. 42(11)
The human papillomavirus (HPV) oncoprotein E7 is a major transforming protein. The E7 protein does not possess intrinsic enzymatic activity, but rather functions through direct and indirect interactions with cellular proteins, several of which are we
Publikováno v:
The Journal of biological chemistry. 283(23)
HPV-16E7 is a major transforming protein, which has been implicated in the development of cervical cancer. The stability of E7 is thus important to ensure its fully functional status. Using the yeast two-hybrid system, we found that USP11 (ubiquitin-