Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Winson S Ho"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 12 (2024)
Glioma evolution is governed by a multitude of dynamic interactions between tumor cells and heterogenous neighboring, non-cancerous cells. This complex ecosystem, termed the tumor microenvironment (TME), includes diverse immune cell types that have g
Externí odkaz:
https://doaj.org/article/271fdd1a4cd84d0ba953fd13238eb8e5
Autor:
Mary C. Clark, Rongze Olivia Lu, Winson S. Ho, Matheus Henrique Dias, René Bernards, Stephen J. Forman
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2333-2337 (2024)
Immune checkpoint blockade has emerged as a potent new tool in the war on cancer. However, only a subset of cancer patients benefit from this therapeutic modality, sparking a search for combination therapies to increase the fraction of responding pat
Externí odkaz:
https://doaj.org/article/08b55194efba462da941ad233f0a4083
Autor:
Winson S. Ho, Isha Mondal, Beisi Xu, Oishika Das, Raymond Sun, Pochin Chiou, Xiaomin Cai, Foozhan Tahmasebinia, Elizabeth McFadden, Caren Yu-Ju Wu, Zhihao Wu, William Matsui, Michael Lim, Zhipeng Meng, Rongze Olivia Lu
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Stimulator of IFN genes type I (STING-Type I) IFN signaling in myeloid cells plays a critical role in effective antitumor immune responses, but STING agonists as monotherapy have shown limited efficacy in clinical trials. The mechanisms that downregu
Externí odkaz:
https://doaj.org/article/9d2712bd859049a58446ca2f3c8ebbb8
Autor:
Jason E. Chung, Omar Iqbal, Chandra Krishnan, Virginia Harrod, Elizabeth Tyler-Kabara, Rongze O. Lu, Winson S. Ho
Publikováno v:
Brain Sciences, Vol 13, Iss 11, p 1515 (2023)
Primitive neuroectodermal tumors of the central nervous system, or CNS neuroblastoma, are rare neoplasms in children. Recently, methylation profiling enabled the discovery of four distinct entities of these tumors. The current treatment paradigm invo
Externí odkaz:
https://doaj.org/article/8e231941bdb941feabc45d32749549c9
Autor:
Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M. Coussens, Daniel D. De Carvalho, David G. DeNardo, Jérôme Galon, Howard L. Kaufman, Tomas Kirchhoff, Michael T. Lotze, Jason J. Luke, Andy J. Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B. Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M. Barnes, Valentin Barsan, Praveen K. Bommareddy, Adrian Bot, Sarah E. Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S. Ho, Heather M. McGee, Anne Monette, Joseph F. Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F. Sweis, Sara Valpione, Roberta Zappasodi, Lisa H. Butterfield, Mary L. Disis, Bernard A. Fox, Alessandra Cesano, Francesco M. Marincola, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-23 (2019)
Abstract Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include th
Externí odkaz:
https://doaj.org/article/864f25d06ad04690a4ef2014434f0547
Autor:
Rongze Olivia Lu, Winson S. Ho
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Glioblastoma (GBM) is the most common malignant brain cancer. Increasing evidence suggests that mitochondrial dysfunction plays a key role in GBM progression as mitochondria is essential in regulating cell metabolism, oxidative stress, and cell death
Externí odkaz:
https://doaj.org/article/3c347484997a4bceb9dd4e242ba8c6b4
Autor:
Winson S. Ho, Herui Wang, Dominic Maggio, John S. Kovach, Qi Zhang, Qi Song, Francesco M. Marincola, John D. Heiss, Mark R. Gilbert, Rongze Lu, Zhengping Zhuang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Protein phosphatase 2A (PP2A) has been proposed as a target for cancer immunotherapy. Here the authors show that pharmacological inhibition of PP2A with a clinically-relevant inhibitor enhances response to immune checkpoint blockade in pre-clinical m
Externí odkaz:
https://doaj.org/article/fa23d329feb04210ba229907d41699e4
Autor:
Isha Mondal, Oishika Das, Raymond Sun, Jian Gao, Bohyeon Yu, Aaron Diaz, Jinan Behnan, Abhishek Dubey, Zhipeng Meng, Emad Eskandar, Beisi Xu, Rongze Olivia. Lu, Winson S. Ho
Publikováno v:
Cancer Research.
Glioblastoma (GBM) is an immunologically “cold” tumor that does not respond to current immunotherapy. Here, we demonstrate a fundamental role for the α-isoform of the catalytic subunit of protein phosphatase-2A (PP2Ac) in regulating glioma immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc43b757fa3450551859fb75515d3db8
https://doi.org/10.1158/0008-5472.can-22-3382
https://doi.org/10.1158/0008-5472.can-22-3382
Autor:
Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M. Coussens, Daniel D. De Carvalho, David G. DeNardo, Jérôme Galon, Howard L. Kaufman, Tomas Kirchhoff, Michael T. Lotze, Jason J. Luke, Andy J. Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B. Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M. Barnes, Valentin Barsan, Praveen K. Bommareddy, Adrian Bot, Sarah E. Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S. Ho, Heather M. McGee, Anne Monette, Joseph F. Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F. Sweis, Sara Valpione, Roberta Zappasodi, Lisa H. Butterfield, Mary L. Disis, Bernard A. Fox, Alessandra Cesano, Francesco M. Marincola, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-2 (2019)
Following publication of the original article [1], the author reported that an author name, Roberta Zappasodi, was missed in the authorship list.
Externí odkaz:
https://doaj.org/article/8274c82abc7148b581d8fa04cb981e68
Publikováno v:
NeuroMolecular Medicine. 24:18-22
As a multi-functional cellular organelle, mitochondrial metabolic reprogramming is well recognized as a hallmark of cancer. The center of mitochondrial metabolism is oxidative phosphorylation (OXPHOS), in which cells use enzymes to oxidize nutrients,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea000a3034c81e0a4db3d11aefbcb02
https://doi.org/10.1007/s12017-021-08678-8
https://doi.org/10.1007/s12017-021-08678-8