Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Winslow S. Caughey"'
Publikováno v:
European Journal of Biochemistry. 128:521-525
Oxidation reactions of carbonyl species of hemoglobins A, Zurich, and Osler with ferricyanide to form met-hemoglobins have been investigated at pH 7.0 and 25°C. The kinetics support a two-step process in which, first, CO is lost to give the unligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d88eb93cc7eccc25690a5dc0d86194
https://doi.org/10.1111/j.1432-1033.1982.tb06996.x
https://doi.org/10.1111/j.1432-1033.1982.tb06996.x
Publikováno v:
Journal of Biological Chemistry. 276:13635-13643
Noncovalent bonding interactions of nitric oxide (NO) with human serum albumin (HSA), human hemoglobin A, bovine myoglobin, and bovine cytochrome c oxidase (CcO) have been explored. The anesthetic nitrous oxide (NNO) occupies multiple sites within ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25823d91456699714aaf5170559d1e7e
https://doi.org/10.1074/jbc.m006588200
https://doi.org/10.1074/jbc.m006588200
Publikováno v:
Science. 287:1503-1506
The transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases for which no effective treatments are available. The likelihood that a bovine form of TSE has crossed species barriers and infected humans underscores the urge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad6542f4d52b49841a519af70240083
https://doi.org/10.1126/science.287.5457.1503
https://doi.org/10.1126/science.287.5457.1503
Publikováno v:
Current Opinion in Microbiology. 2:563-566
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955d5fa24d9579c7a3c15f40e841a9ff
https://doi.org/10.1016/s1369-5274(99)00020-x
https://doi.org/10.1016/s1369-5274(99)00020-x
Publikováno v:
Free Radical Biology and Medicine. 26:1388-1395
The source(s) of reactive partially reduced oxygen species associated with myocardial ischemia/reperfusion injury remain unclear and controversial. Myoglobin has not been viewed as a participant but is present in relatively high concentrations in hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f45c8f3339b445de5bb1ac1fdca3c55
https://doi.org/10.1016/s0891-5849(98)00338-4
https://doi.org/10.1016/s0891-5849(98)00338-4
Publikováno v:
Proceedings of the National Academy of Sciences. 95:12117-12122
A central aspect of pathogenesis in the transmissible spongiform encephalopathies or prion diseases is the conversion of normal protease-sensitive prion protein (PrP-sen) to the abnormal protease-resistant form, PrP-res. Here we identify porphyrins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5df7cfa60ff3bc30f7bb17d46a94da9
https://doi.org/10.1073/pnas.95.21.12117
https://doi.org/10.1073/pnas.95.21.12117
Autor:
David A. Kocisko, Grant Y. Roper, John D. Morrey, Richard E. Race, Winslow S. Caughey, Byron Caughey
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:759-761
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2207a24c95019cd1f2c8ccf3bbbec8a1
https://doi.org/10.1128/aac.50.2.759-761.2006
https://doi.org/10.1128/aac.50.2.759-761.2006
Publikováno v:
Biochemical and Biophysical Research Communications. 212:1054-1060
Reduction of nitric oxide (NO) to nitrous oxide (N2O) is catalyzed by bovine heart cytochrome c oxidase (CcO) in anaerobic solutions at pH 7.2 and 20 degrees C. Cyanide inhibits and forms Fea3(3+)CN. The mononitrosyl (Fea3(2+)NO), but not the dinitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71e092c1496a84e208d25bbb3c20f4f
https://doi.org/10.1006/bbrc.1995.2076
https://doi.org/10.1006/bbrc.1995.2076
Publikováno v:
Journal of Pharmaceutical Sciences. 84:387-392
Effects of 10-30% (v/v) of dimethyl sulfoxide, glycerol, and ethylene glycol on the H-O-H bending vibration of water and the amide I bands of horse heart cytochrome c and chicken egg white lysozyme in 25 mM sodium phosphate buffer (pH 7.4) were exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5a11e2249acf48ad80dc71c0c76e34
https://doi.org/10.1002/jps.2600840402
https://doi.org/10.1002/jps.2600840402
Publikováno v:
Journal of Biological Chemistry. 270:4270-4279
Effects of changes in oxidation state at the other metal centers on oxidized heme a3 cyanide of bovine heart cytochrome c oxidase have been investigated. Only one CN- binds, giving Fe3+a3CN, in fully-oxidized cytochrome c oxidase and its 1-, 2-, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa79a9b2a347e742aaf3a5201d0d3c4
https://doi.org/10.1074/jbc.270.9.4270
https://doi.org/10.1074/jbc.270.9.4270