B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates.

Autor: Kaminski J; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA., Fleming RA; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., Alvarez-Calderon F; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Winschel MB; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., McGuckin C; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., Ho EE; 2seventy bio, Cambridge, MA., Eng F; 2seventy bio, Cambridge, MA., Rui X; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., Keskula P; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., Cagnin L; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., Charles J; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., Zavistaski J; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA., Margossian SP; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Kapadia MA; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Rottman JB; 2seventy bio, Cambridge, MA., Lane J; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA., Baumeister SHC; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Tkachev V; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.; Ragon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge, MA., Kean LS; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Gerdemann U; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA.

Publikováno v: Blood [Blood] 2024 Jul 04; Vol. 144 (1), pp. 46-60.