Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.

Autor: Joost J Leenders, Wino J Wijnen, Ingeborg van der Made, Monika Hiller, Melissa Swinnen, Thierry Vandendriessche, Marinee Chuah, Yigal M Pinto, Esther E Creemers

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36754 (2012)

The Kruppel-like factor (KLF) family of transcription factors regulates diverse cell biological processes including proliferation, differentiation, survival and growth. Previous studies have shown that KLF15 inhibits cardiac hypertrophy by repressing

Externí odkaz: https://doaj.org/article/1fd6139a87124b14b3bf8ee5a8095a4e

MiR30-GALNT1/2 axis-mediated glycosylation contributes to the increased secretion of inactive human prohormone for brain natriuretic peptide (proBNP) from failing hearts

Autor: Kosai Cho, Aoi Fujishima, Wino J. Wijnen, Kenji Kangawa, Hideyuki Kinoshita, Takao Kato, Kazuwa Nakao, Toshio Nishikimi, Yasuaki Nakagawa, Jun K. Yamashita, Motohiro Nishida, Hideaki Inazumi, Hiroyuki Okamoto, Shogo Oka, Kazuhiro Nakao, Hiroyuki Fukushima, Naoto Minamino, Koichiro Kuwahara, Takeshi Kimura, Esther E. Creemers, Takayoshi Tsutamoto

Publikováno v: Journal of the American Heart Association, 6(2):e003601. Wiley-Blackwell
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

BackgroundRecent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1c5cdc6fcb4329223145aed1fc5a5f
http://hdl.handle.net/2433/227809

The microRNA-15 family inhibits the TGF beta-pathway in the heart

Autor: Nina E. de Groot, Dirk J. Duncker, Marie-José Goumans, Maarten M.G. van den Hoogenhof, Ingeborg van der Made, Anke J. Tijsen, Esther E. Creemers, Kees Fluiter, Blanche Schroen, Sergey Alekseev, Jolanda van der Velden, Wino J. Wijnen, Yigal M. Pinto, Elza D. van Deel

Publikováno v: Cardiovascular Research, 104(1), 61-71
Cardiovascular Research, 104(1), 61-71. Oxford University Press
Tijsen, A J, van der Made, I, van den Hoogenhof, M M, Wijnen, W J, van Deel, E D, de Groot, N E, Alekseev, S, Fluiter, K, Schroen, B, Goumans, M J, van der Velden, J, Duncker, D J, Pinto, Y M & Creemers, E E 2014, ' The microRNA-15 family inhibits the TGF beta-pathway in the heart ', Cardiovascular Research, vol. 104, no. 1, pp. 61-71 . https://doi.org/10.1093/cvr/cvu184
Cardiovascular research, 104(1), 61-71. Oxford University Press

Aims The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the TGF beta-pathway is crucial for this remodelling. Here we tested the hypothesis that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558eb52c9dfc5ef0bfe0b2262817caea
http://hdl.handle.net/1887/100342

Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications

Autor: Esther E. Creemers, Ingeborg van der Made, Yigal M. Pinto, Monika Hiller, Marinee Chuah, Joost J. Leenders, Wino J. Wijnen, Thierry VandenDriessche, Melissa Swinnen

Publikováno v: PLoS ONE
PLoS ONE, 7(5). Public Library of Science
PLoS ONE, Vol 7, Iss 5, p e36754 (2012)
PloS one, 7 (5

The Kruppel-like factor (KLF) family of transcription factors regulates diverse cell biological processes including proliferation, differentiation, survival and growth. Previous studies have shown that KLF15 inhibits cardiac hypertrophy by repressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c713c7b7b286ad3e57a36d569d8430c2
https://pubmed.ncbi.nlm.nih.gov/22586493

Cardiomyocyte-Specific miRNA-30c Over-Expression Causes Dilated Cardiomyopathy

Autor: Ingeborg van der Made, Jan M. Ruijter, Jaco Hagoort, Wino J. Wijnen, Riekelt H. Houtkooper, Anke J. Tijsen, Daisy I. Picavet, Yigal M. Pinto, Bouke A. de Boer, Esther E. Creemers, Iliana A. Chatzispyrou, Vincent Everts, Henk A. van Veen, Stephanie van den Oever, Monika Hiller

Publikováno v: PLoS ONE, 9(5). Public Library of Science
PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e96290 (2014)

MicroRNAs (miRNAs) regulate many aspects of cellular function and their deregulation has been implicated in heart disease. MiRNA-30c is differentially expressed in the heart during the progression towards heart failure and in vitro studies hint to it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fb5788c1af4d1452f92f29ae39d772
https://doi.org/10.1371/journal.pone.0096290