Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Winnie S, Liang"'
Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease
Autor:
Qi Wang, Jerry Antone, Eric Alsop, Rebecca Reiman, Cory Funk, Jaroslav Bendl, Joel T. Dudley, Winnie S. Liang, Timothy L. Karr, Panos Roussos, David A. Bennett, Philip L. De Jager, Geidy E. Serrano, Thomas G. Beach, Kendall Van Keuren-Jensen, Diego Mastroeni, Eric M. Reiman, Benjamin P. Readhead
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer’s disease (AD). Integration with complementary multiomics data such as genetics, proteomics and clinical data provides powerful oppor
Externí odkaz:
https://doaj.org/article/583e7a46c0434985a97259a70db5d4e3
Autor:
Winnie S. Liang, Brett Beaulieu-Jones, Susan Smalley, Michael Snyder, Laura H. Goetz, Nicholas J. Schork
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
In recent years, the development of sensor and wearable technologies have led to their increased adoption in clinical and health monitoring settings. One area that is in early, but promising, stages of development is the use of biosensors for therape
Externí odkaz:
https://doaj.org/article/8a5a3f2f07dd4f9082012862749da0d7
Autor:
Sourat Darabi, James R. Howe, Mackenzie D. Postel, Michael J. Demeure, Winnie S. Liang, David W. Craig
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Small intestine neuroendocrine tumors (SI-NETs), also called “carcinoids,” are insidious tumors that are often metastatic when diagnosed. Limited studies on the mutational landscape of small bowel carcinoids indicate that these tumors
Externí odkaz:
https://doaj.org/article/916d3fb7284b404da52066bed17a902d
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The development of effective treatments to prevent and slow Alzheimer’s disease (AD) pathogenesis is needed in order to tackle the steady increase in the global prevalence of AD. This challenge is complicated by the need to identify key health shif
Externí odkaz:
https://doaj.org/article/5e4b09a9b686471288193fa58a0527cf
Autor:
Rebecca F. Halperin, Apurva Hegde, Jessica D. Lang, Elizabeth A. Raupach, C4RCD Research Group, Christophe Legendre, Winnie S. Liang, Patricia M. LoRusso, Aleksandar Sekulic, Jeffrey A. Sosman, Jeffrey M. Trent, Sampathkumar Rangasamy, Patrick Pirrotte, Nicholas J. Schork
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The robust detection of disease-associated splice events from RNAseq data is challenging due to the potential confounding effect of gene expression levels and the often limited number of patients with relevant RNAseq data. Here we present a
Externí odkaz:
https://doaj.org/article/a3220a92cf2645288aad59ed2f183636
Autor:
Shobana Sekar, Winnie S. Liang
Publikováno v:
Non-coding RNA Research, Vol 4, Iss 1, Pp 23-29 (2019)
Within the last decade, active research on circular RNAs (circRNAs) has dramatically improved our understanding of the expression and function of these non-coding RNAs. While several mechanisms for circRNA function have been proposed, including seque
Externí odkaz:
https://doaj.org/article/f299322b70ac41d0a1355a8994b74da8
Autor:
Patricia M LoRusso, Aleksandar Sekulic, Jeffrey A Sosman, Winnie S Liang, John Carpten, David W Craig, David B Solit, Alan H Bryce, Jeffrey A Kiefer, Jessica Aldrich, Sara Nasser, Rebecca Halperin, Sara A Byron, Mary Jo Pilat, Scott A Boerner, Diane Durecki, William P D Hendricks, Daniel Enriquez, Tyler Izatt, Jonathan Keats, Christophe Legendre, Svetomir N Markovic, Amy Weise, Fatima Naveed, Jessica Schmidt, Gargi D Basu, Shobana Sekar, Jonathan Adkins, Erica Tassone, Karthigayini Sivaprakasam, Victoria Zismann, Valerie S Calvert, Emanuel F Petricoin, Leslie Anne Fecher, Christopher Lao, J Paul Eder, Nicholas J Vogelzang, Jane Perlmutter, Mark Gorman, Barbara Manica, Lisa Fox, Nicholas Schork, Daniel Zelterman, Michelle DeVeaux, Richard W Joseph, C Lance Cowey, Jeffrey M Trent
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0248097 (2021)
Although combination BRAF and MEK inhibitors are highly effective for the 40-50% of cutaneous metastatic melanomas harboring BRAFV600 mutations, targeted agents have been ineffective for BRAFV600wild-type (wt) metastatic melanomas. The SU2C Genomics-
Externí odkaz:
https://doaj.org/article/ea286e5ad5d3466fb04534c8639561db
Autor:
Havell Markus, Tania Contente-Cuomo, Maria Farooq, Winnie S. Liang, Mitesh J. Borad, Shivan Sivakumar, Simon Gollins, Nhan L. Tran, Harshil D. Dhruv, Michael E. Berens, Alan Bryce, Aleksandar Sekulic, Antoni Ribas, Jeffrey M. Trent, Patricia M. LoRusso, Muhammed Murtaza
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Pre-analytical factors can significantly affect circulating cell-free DNA (cfDNA) analysis. However, there are few robust methods to rapidly assess sample quality and the impact of pre-analytical processing. To address this gap and to evalua
Externí odkaz:
https://doaj.org/article/754bebe0d60d4db2a753e90d4a1c1a88
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Circular RNAs (circRNAs) are a novel class of endogenous, non-coding RNAs that form covalently closed continuous loops and that are both highly conserved and abundant in the mammalian brain. A role for circRNAs in sponging microRN
Externí odkaz:
https://doaj.org/article/be101da354ec4821bc2e4fd0a621837e
Autor:
Michela Dell’Orco, Amir Elyaderani, Annika Vannan, Shobana Sekar, Gregory Powell, Winnie S. Liang, Janet L. Neisewander, Nora I. Perrone-Bizzozero
Publikováno v:
Biology, Vol 10, Iss 9, p 939 (2021)
The RNA-binding protein HuD (a.k.a., ELAVL4) is involved in neuronal development and synaptic plasticity mechanisms, including addiction-related processes such as cocaine conditioned-place preference (CPP) and food reward. The most studied function o
Externí odkaz:
https://doaj.org/article/8438b904481540978b037c8cec99c614