Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Winnie M. Leung"'
Autor:
Jiafen Gong, Gengming He, Cheng Wang, Claire Bartlett, Naim Panjwani, Scott Mastromatteo, Fan Lin, Katherine Keenan, Julie Avolio, Anat Halevy, Michelle Shaw, Mohsen Esmaeili, Guillaume Côté-Maurais, Damien Adam, Stéphanie Bégin, Candice Bjornson, Mark Chilvers, Joe Reisman, April Price, Michael Parkins, Richard van Wylick, Yves Berthiaume, Lara Bilodeau, Dimas Mateos-Corral, Daniel Hughes, Mary J. Smith, Nancy Morrison, Janna Brusky, Elizabeth Tullis, Anne L. Stephenson, Bradley S. Quon, Pearce Wilcox, Winnie M. Leung, Melinda Solomon, Lei Sun, Emmanuelle Brochiero, Theo J. Moraes, Tanja Gonska, Felix Ratjen, Johanna M. Rommens, Lisa J. Strug
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) are CF-causing. CFTR modulators target variants to improve lung function, but marked variability in response exists and current therapies do not address
Externí odkaz:
https://doaj.org/article/c9a883e6061748a2ad1bb0acfad420a2
Publikováno v:
Respiratory Medicine Case Reports, Vol 46, Iss , Pp 101938- (2023)
Elexacaftor-tezacaftor-ivacaftor (ETI) therapy is shown to improve the health of individuals with cystic fibrosis (CF) who have the F508del variant. There are in vitro studies showing benefit with ETI for select rare CF variants. Limited data exists
Externí odkaz:
https://doaj.org/article/e94398d5b34c4afdb72d884d77e176f4
Autor:
Scott Mastromatteo, Angela Chen, Jiafen Gong, Fan Lin, Bhooma Thiruvahindrapuram, Wilson W.L. Sung, Joe Whitney, Zhuozhi Wang, Rohan V. Patel, Katherine Keenan, Anat Halevy, Naim Panjwani, Julie Avolio, Cheng Wang, Guillaume Côté-Maurais, Stéphanie Bégin, Damien Adam, Emmanuelle Brochiero, Candice Bjornson, Mark Chilvers, April Price, Michael Parkins, Richard van Wylick, Dimas Mateos-Corral, Daniel Hughes, Mary Jane Smith, Nancy Morrison, Elizabeth Tullis, Anne L. Stephenson, Pearce Wilcox, Bradley S. Quon, Winnie M. Leung, Melinda Solomon, Lei Sun, Felix Ratjen, Lisa J. Strug
Publikováno v:
HGG Advances, Vol 4, Iss 1, Pp 100156- (2023)
Summary: Phasing of heterozygous alleles is critical for interpretation of cis-effects of disease-relevant variation. We sequenced 477 individuals with cystic fibrosis (CF) using linked-read sequencing, which display an average phase block N50 of 4.3
Externí odkaz:
https://doaj.org/article/000a1d3c634e4c91b0e728e58acc8bdb
Autor:
Scott Mastromatteo, Angela Chen, Jiafen Gong, Fan Lin, Bhooma Thiruvahindrapuram, Wilson WL Sung, Joe Whitney, Zhuozhi Wang, Rohan V Patel, Katherine Keenan, Anat Halevy, Naim Panjwani, Julie Avolio, Cheng Wang, Guillaume Côté-Maurais, Stéphanie Bégin, Damien Adam, Emmanuelle Brochiero, Candice Bjornson, Mark Chilvers, April Price, Michael Parkins, Richard van Wylick, Dimas Mateos-Corral, Daniel Hughes, Mary Jane Smith, Nancy Morrison, Elizabeth Tullis, Anne L Stephenson, Pearce Wilcox, Bradley S Quon, Winnie M Leung, Melinda Solomon, Lei Sun, Felix Ratjen, Lisa J Strug
Phasing of heterozygous alleles is critical for interpretation of cis-effects of disease-relevant variation. For population studies, phase is often inferred from external data but read-based phasing approaches that span long genomic distances would b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2bee7a4d3021ec41ff4c5915cdb67a8
https://doi.org/10.1101/2022.03.28.486092
https://doi.org/10.1101/2022.03.28.486092
Publikováno v:
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 2:133-137
INTRODUCTION: Canadian Cystic Fibrosis (CF) patients spent over 24,900 days in hospital and underwent 867 home intravenous (IV) antibiotic treatments in 2014. CF pulmonary exacerbations are treated...
Autor:
Winnie M. Leung, Jamil N. Kanji, Josette Salgado, James E. A. Zlosnik, Grace Y. Lam, Neil E. Brown
Publikováno v:
Clinical Microbiology Newsletter. 38:191-193
Autor:
Isabelle Laforest-Lapointe, Laura Rossi, Barbara Waddell, Yves Berthiaume, Ranjani Somayaji, Michael D. Parkins, Michael G. Surette, Matthew L. Workentine, Nicole Acosta, Harvey R. Rabin, Alya Heirali, Bradley S. Quon, Winnie M. Leung, Douglas G. Storey
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 18(6)
Background To improve clinical outcomes, cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa infections are prescribed inhaled anti-pseudomonal antibiotics. Although, a diverse microbial community exists within CF airways, little is kno
Autor:
Shelby Sissons, Maeve P. Smith, Winnie M. Leung, Neil E. Brown, Grace Y. Lam, Mathew P. Estey
Publikováno v:
Journal of Cystic Fibrosis. 18:e14-e15
Autor:
Jan Dayton, Kimberley Mulchey, Neil E. Brown, Michelle Doll-Shankaruk, Karina Rodriguez-Capote, Grace Y. Lam, Mathew P. Estey, Maeve P. Smith, Winnie M. Leung, Dylan Thomas, Trefor Higgins
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 17(1)
Objective To determine whether serum fructosamine correlates with glycemic control and clinical outcomes in patients being screened for cystic fibrosis-related diabetes (CFRD). Methods Fructosamine and percent predicted forced expiratory volume in 1s
Autor:
Tomasz Hruczkowski, Emad Saad, Jillian Peters, Kimberley Mulchey, Richard Coulden, Sanjaya Chandrarathne, Gregg Blevins, Winnie M. Leung, Dilini Vethanayagam, Gavin Y. Oudit, Brian McNab, Jeremy Beach
Publikováno v:
Chest. 152:A454