Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Winnie, Luu"'
Autor:
Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100362- (2023)
Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and posttranslational levels. While some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzyme
Externí odkaz:
https://doaj.org/article/c248162951394c64a07c42242ea8d86c
Autor:
Ivy K N Chiang, Matthew S Graus, Nils Kirschnick, Tara Davidson, Winnie Luu, Richard Harwood, Keyi Jiang, Bitong Li, Yew Yan Wong, Mehdi Moustaqil, Emmanuelle Lesieur, Renae Skoczylas, Valerie Kouskoff, Jan Kazenwadel, Luis Arriola‐Martinez, Emma Sierecki, Yann Gambin, Kari Alitalo, Friedmann Kiefer, Natasha L Harvey, Mathias Francois
Refereed/Peer-reviewed Despite a growing catalog of secreted factors critical for lymphatic network assembly, little is known about the mechanisms that modulate the expression level of these molecular cues in blood vascular endothelial cells (BECs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b743e950455b85e2c844ab2d4d566703
https://hdl.handle.net/11541.2/32559
https://hdl.handle.net/11541.2/32559
Autor:
Mehdi Moustaqil, Frederic A. Meunier, Alex Jade McCann, Frank Fontaine, Yann Gambin, Peter Koopman, Ailisa Blum, Winnie Luu, Jieqiong Lou, Hui Liu, Mathias Francois, Matthew S Graus, Paulina Rudolffi-Soto, Zhe Liu, Emma Sierecki, Elizabeth Hinde
Publikováno v:
Nucleic Acids Research
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly p
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 888-897 (2015)
Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires the actions of more than twenty enzymes to reach the final product, through two alternate pat
Externí odkaz:
https://doaj.org/article/0edb925724c042fb831c75c0dae361c4
Autor:
Winnie Luu, Eser J. Zerenturk, Ika Kristiana, Martin P. Bucknall, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 410-420 (2014)
The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis,
Externí odkaz:
https://doaj.org/article/0bc11d238d6a4d2ead8669b0473e7254
Autor:
Samuel J. Gullo, Nicola A. Scott, Winnie Luu, Andrew J. Brown, Isabelle M. Capell-Hattam, Laura J. Sharpe
Publikováno v:
Biochemical Journal
Cholesterol synthesis is a tightly controlled pathway, with over 20 enzymes involved. Each of these enzymes can be distinctly regulated, helping to fine-tune the production of cholesterol and its functional intermediates. Several enzymes are degraded
Autor:
Davidson Tl, Emmanuelle Lesieur, Winnie Luu, Chiang Ikn, Friedemann Kiefer, Mehdi Moustaqil, Natasha L. Harvey, Mathias Francois, Arriola-Martinez L, Kari Alitalo, Kirschnick N, Jiang K, Renae Skoczylas, Kazenwadel J, Emma Sierecki, Kouskoff, Yann Gambin
Despite a growing catalogue of secreted factors critical for lymphatic network assembly, little is known about the mechanisms that modulate the expression level of these molecular cues in blood vascular endothelial cells (BECs). Here, we show that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cdfcd2f1c2e9d1bd8098d2983b8c627
https://doi.org/10.1101/2021.07.02.450967
https://doi.org/10.1101/2021.07.02.450967
Autor:
Elizabeth Hinde, Winnie Luu, Jieqiong Lou, Alex Jade McCann, Frederic A. Meunier, Hui Liu, Mathias Francois, Ailisa Blum, Peter Koopman, Emma Sierecki, Mehdi Moustaqil, Zhe Liu, Frank Fontaine, Yann Gambin
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c385eab7881711566225045980adbf
https://doi.org/10.1101/2020.11.11.378968
https://doi.org/10.1101/2020.11.11.378968
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 165:363-368
Cholesterol is essential for survival, but too much or too little can cause disease. Thus, cholesterol levels must be kept within close margins. 7-dehydrocholesterol reductase (DHCR7) is a terminal enzyme of cholesterol synthesis, and is essential fo
Publikováno v:
Journal of Biological Chemistry. 291:8363-8373
Cholesterol is detrimental to human health in excess but is also essential for normal embryogenesis. Hence, enzymes involved in its synthesis possess many layers of regulation to achieve balanced cholesterol levels. 7-Dehydrocholesterol reductase (DH