Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density

Autor: Somasundaram, Veena, Ridnour, Lisa A., Cheng, Robert YS., Walke, Abigail J., Kedei, Noemi, Bhattacharyya, Dibyangana D., Wink, Adelaide L., Edmondson, Elijah F., Butcher, Donna, Warner, Andrew C., Dorsey, Tiffany H., Scheiblin, David A., Heinz, William, Bryant, Richard J., Kinders, Robert J., Lipkowitz, Stanley, Wong, Stephen TC., Pore, Milind, Hewitt, Stephen M., McVicar, Daniel W., Anderson, Stephen K., Chang, Jenny, Glynn, Sharon A., Ambs, Stefan, Lockett, Stephen J., Wink, David A.

Publikováno v: In Redox Biology December 2022 58

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Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Autor: Ridnour LA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Heinz WF; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Cheng RYS; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Wink AL; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Kedei N; Collaborative Protein Technology Resource (CPTR) Nanoscale Protein Analysis, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Pore M; Imaging Mass Cytometry, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Imtiaz F; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Femino EL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Gonzalez AL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Coutinho LL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Moffat RL; Optical Microscopy and Analysis Laboratory, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Butcher D; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Edmondson EF; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia., Rangel MC; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Kinders RJ; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Rittscher J; Institute of Biomedical Engineering, Big Data Institute, Ludwig Oxford Branch, University of Oxford, Oxford, United Kingdom., Lipkowitz S; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Wong STC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Anderson SK; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., McVicar DW; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Glynn SA; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Billiar TR; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Chang JC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Hewitt SM; Laboratory of Pathology Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Lockett SJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Wink DA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2766-2782.

Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients.

Autor: Ridnour LA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Cheng RYS; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Heinz WF; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Pore M; Imaging Mass Cytometry Frederick National Laboratory for Cancer Research., Gonzalez AL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Femino EL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Moffat R; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Wink AL; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Imtiaz F; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Coutinho L; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.; Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, SP, Brazil., Butcher D; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute., Edmondson EF; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute., Rangel MC; Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, SP, Brazil., Wong STC; Houston Methodist Weill Cornell Medical College, Houston TX., Lipkowitz S; Women's Malignancies Branch, CCR, NCI, NIH., Glynn S; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Vitek MP; (Mike Duke)., McVicar DW; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA., Anderson SK; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.; Basic Science Program, Frederick National Laboratory for Cancer Research., Paolocci N; Division of Cardiology, Department of Medicine, Johns Hopkins University, and Department of Biomedical Sciences, University of Padova, Italy.; Laboratory of Pathology CCR, NCI, NIH., Hewitt SM; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD., Ambs S; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA., Billiar TR; Mary and Ron Neal Cancer Center, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX., Chang JC; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD.; Imaging Mass Cytometry Frederick National Laboratory for Cancer Research.; Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, SP, Brazil.; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute.; Houston Methodist Weill Cornell Medical College, Houston TX.; Women's Malignancies Branch, CCR, NCI, NIH.; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland.; (Mike Duke).; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.; Basic Science Program, Frederick National Laboratory for Cancer Research.; Division of Cardiology, Department of Medicine, Johns Hopkins University, and Department of Biomedical Sciences, University of Padova, Italy.; Laboratory of Pathology CCR, NCI, NIH.; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD.; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.; Mary and Ron Neal Cancer Center, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX., Lockett SJ; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Wink DA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 23. Date of Electronic Publication: 2023 Dec 23.