Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Wingchi K Leung"'
Abstract P6-10-11: Engineered neoantigen-specific T cell receptors to treat metastatic breast cancer
Autor:
Paul Shafer, Wingchi K. Leung, Mae L. Woods, Carlos Rodriguez-Plata, Arushana Ali, Saisha Nalawade, Lauren M. Kelley, Jarrett Joubert, Anthony Manliguez, Spyridoula Vasileiou, Suzanne A. Fuqua, Premal Lulla, Cliona Rooney, Ann Leen, Valentina Hoyos
Publikováno v:
Cancer Research. 83:P6-10
T cell receptor engineered T cell (TCR T) therapy has emerged as a promising therapeutic modality for solid cancer following recent trials demonstrating the safety and efficacy of TCR T therapies against some types of metastatic solid cancers. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d1ee7ef08c8ef934bf2fea1efec5357
https://doi.org/10.1158/1538-7445.sabcs22-p6-10-11
https://doi.org/10.1158/1538-7445.sabcs22-p6-10-11
Publikováno v:
Current Stem Cell Reports. 6:17-29
Virus-associated malignancies are a global health burden, constituting 10–12% of cancers worldwide. As these tumors express foreign viral antigens that can elicit specific T cell responses, virus-directed immunotherapies are a promising treatment s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82694093b8d2dac11cd43ead1b1ed1c8
https://doi.org/10.1007/s40778-020-00170-6
https://doi.org/10.1007/s40778-020-00170-6
Autor:
Wingchi K. Leung, Ann M. Leen, Premal Lulla, Aster Workineh, Daniel Brenner, Norihiro Watanabe, Shivani Mukhi, Ifigeneia Tzannou
Publikováno v:
Blood Advances. 4:387-397
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative option for relapsed or refractory acute myeloid leukemia (AML). However, more than half ultimately experience disease relapse that is associated with a dismal median
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d852be847ab3a3d47bed9c42eef01658
https://doi.org/10.1182/bloodadvances.2019000715
https://doi.org/10.1182/bloodadvances.2019000715
Publikováno v:
Curr Opin Immunol
Adoptive transfer of CD19-specific chimeric antigen receptor T-cells (CAR-T cells) has transformed the treatment paradigm of relapsed/refractory (R/R) CD19 B-cell malignancies, dramatically improving remission rates and cures in patients with chemo-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e6df1f8e5d2b504ab828c1aafd1c38
https://pubmed.ncbi.nlm.nih.gov/34800921
https://pubmed.ncbi.nlm.nih.gov/34800921
Autor:
Wingchi K. Leung, Helen E. Heslop
Publikováno v:
Cancer Immunology Research. 7:528-533
Although T cells genetically modified with chimeric antigen receptors became the first immune effector product to obtain FDA approval, T-cell products that recognize their antigenic targets through their native receptors have also produced encouragin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de4cf0a8ddfa460b79b6ee09a6dc37b
https://doi.org/10.1158/2326-6066.cir-18-0888
https://doi.org/10.1158/2326-6066.cir-18-0888
Autor:
Rammurti T. Kamble, Premal Lulla, Spyridoula Vasileiou, Quillan Huang, George Carrum, Hussein Hamad, LaQuisa Hill, Shivani Mukhi, Ann M. Leen, Wingchi K Leung, Carlos A. Ramos
Publikováno v:
Blood. 134:4225-4225
Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by bone marrow failure and a propensity to progress to acute myeloid leukemia (AML). A core component of the underlying pathogenesis in MDS is deregulation of inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b7e057e21e332f49c4bf3236c5c7743
https://doi.org/10.1182/blood-2019-126792
https://doi.org/10.1182/blood-2019-126792