Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Wing-Ping Fong"'
Publikováno v:
Chemical Communications. 59:3471-3474
A smart photosensitiser has been designed and synthesised that can be selectively activated by the senescence-associated β-galactosidase in senescent cells, leading to effective killing of the cells via photodynamic action.
Autor:
Wing Ping Fong, Yau Sang Chan, Xiu Juan Ye, Wen Liang Pan, Jack Ho Wong, Tzi Bun Ng, Chris Zhi Yi Zhang, Evandro Fei Fang
Supplementary Figures 1-3 from Momordica Charantia Lectin, a Type II Ribosome Inactivating Protein, Exhibits Antitumor Activity toward Human Nasopharyngeal Carcinoma Cells In Vitro and In Vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21798775d184c033a21596b8d56c8514
https://doi.org/10.1158/1940-6207.22525227
https://doi.org/10.1158/1940-6207.22525227
Autor:
Lu Feng, Yee-Lok Yuen, Jian Xu, Xing Liu, Martin Yan-Chun Chan, Kai Wang, Wing-Ping Fong, Wing-Tai Cheung, Susanna Sau-Tuen Lee
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1114-1131 (2017)
PPARα has been known to play a pivotal role in orchestrating lipid, glucose, and amino acid metabolism via transcriptional regulation of its target gene expression during energy deprivation. Recent evidence has also suggested that PPARα is involved
Externí odkaz:
https://doaj.org/article/221c9c11f2354c209508d66df076c479
Publikováno v:
Journal of the American Chemical Society. 144:10647-10658
Delivery of functional proteins into the intracellular space has been a challenging task that could lead to a myriad of therapeutic applications. We report herein a novel bioconjugation strategy for enzyme modification and selective delivery into can
Publikováno v:
Colorants; Volume 1; Issue 2; Pages: 193-207
Photodynamic therapy (PDT) is an established treatment modality for a range of superficial and localized cancers. There has been tremendous interest in the development of advanced photosensitizers that exhibit superior photophysical properties, high
Publikováno v:
Biomaterials Science. 10:189-201
A series of glutathione (GSH)-responsive polydopamine (PDA) nanoparticles (NPs) were prepared using a disulfide-linked dopamine dimer as starting material, of which the size could be tuned systematically by adjusting the amount of ammonia solution us
Publikováno v:
Journal of Medicinal Chemistry. 64:17455-17467
Two dual stimuli-activated photosensitizers were developed, in which two or three glutathione (GSH)-responsive 2,4-dinitrobenzenesulfonate (DNBS)-substituted zinc(II) phthalocyanine units were connected via one or two cathepsin B-cleavable Gly-Phe-Le
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189219 (2017)
Candida albicans is a clinically important human fungal pathogen. We previously identified the presence of cell-associated phytase activity in C. albicans. Here, we reveal for the first time, that orf19.3727 contributes to phytase activity in C. albi
Externí odkaz:
https://doaj.org/article/4181169810b540eba2067d21e2db62be
Publikováno v:
ACS applied materialsinterfaces. 14(13)
The delivery and activation of photosensitizers in a specific manner is crucial in photodynamic therapy. For an antitumoral application, it can confine the photodynamic action on the cancer cells, thereby enhancing the treatment efficacy and reducing
Publikováno v:
Molecular Pharmaceutics. 17:3941-3951
In cancer photodynamic therapy (PDT), a photosensitizer taken up by cancer cells can generate reactive oxygen species upon near-infrared light activation to induce cancer cell death. To increase PDT potency and decrease its adverse effect, one approa