Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Wing W. Lam"'
Autor:
Hollie Skaggs, Heng-Keang Lim, Damir Simic, Alessandro Pocai, Wing W. Lam, Mark R. Player, Rhys Salter, Bhanu Singh, Monicah A. Otieno, Jan Snoeys, Avi Ghosh
Publikováno v:
Toxicological Sciences. 163:374-384
TAK-875, a GPR40 agonist, was withdrawn from Phase III clinical trials due to drug-induced liver injury (DILI). Mechanistic studies were conducted to identify potential DILI hazards (covalent binding burden (CVB), hepatic transporter inhibition, mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c8dabc0d28e07f9ae32807bc3b23e3
https://doi.org/10.1093/toxsci/kfx040
https://doi.org/10.1093/toxsci/kfx040
Autor:
Erio Barale, Katia Karalis, Riccardo Barrile, Kyung-Jin Jang, Monica Singer, Abhishek Srivastava, Anna Herland, Josiah Sliz, Barry Jones, Hyoungshin Park, Janna Nawroth, Geraldine A. Hamilton, Dominic P. Williams, Wing W. Lam, Gauri Kulkarni, Jonathan E. Rubins, Suzzette Haney, Linda C. Andersson, Manisha Sonee, Konstantia Kodella, Debora B. Petropolis, Monicah A. Otieno, Heng-Keang Lim, Lorna Ewart, Bhanu Singh, Carl L. Manthey, Janey Ronxhi, Donald E. Ingber, David Conegliano, Anthony J. Streeter, Damir Simic
Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans contributing to drug failures in the clinic. Here we applied microengineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77153c2fec6be0820279936c4ea70992
Autor:
Bhanu Singh, Suzzette Haney, Carl L. Manthey, Riccardo Barrile, Anna Herland, Dominic P. Williams, Manisha Sonee, Katia Karalis, Monica Singer, David Conegliano, Heng-Keang Lim, Geraldine A. Hamilton, Donald E. Ingber, Monicah A. Otieno, Anthony J. Streeter, Lorna Ewart, Erio Barale, Linda C. Andersson, Barry Jones, Wing W. Lam, Damir Simic, Konstantia Kodella, Debora B. Petropolis, Josiah Sliz, Janey Ronxhi, Janna Nawroth, Abhishek Srivastava, Kyung-Jin Jang, Gauri Kulkarni, Hyoungshin Park, Jonathan E. Rubins
Publikováno v:
Science translational medicine. 11(517)
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e12fac7c745aecb2cdd286e4f142c77
https://pubmed.ncbi.nlm.nih.gov/31776474
https://pubmed.ncbi.nlm.nih.gov/31776474
Autor:
Sanath K. Meegalla, Jose Silva, Thomas Wilde, Michael P. Winters, Jianying Liu, Fran Xu, Shuyuan Zhao, Brian Rady, Jenson Qi, Alessandro Pocai, Paul S. Lee, Tonya Martin, Mark R. Player, James Littrell, Monicah A. Otieno, Wing W. Lam, James C. Lanter, Heng-Keang Lim, Hui Huang
[Image: see text] GPR40 is a G-protein-coupled receptor which mediates fatty acid-induced glucose-stimulated insulin secretion from pancreatic beta cells and incretion release from enteroendocrine cells of the small intestine. GPR40 full agonists exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd9c88f3c2b104a8517817db45fd252
https://europepmc.org/articles/PMC6331191/
https://europepmc.org/articles/PMC6331191/
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781627037419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6837023417d1efe0ef51d02a5a572682
https://doi.org/10.1007/978-1-62703-742-6_26
https://doi.org/10.1007/978-1-62703-742-6_26
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781627037419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::454ccfeebe7b9d7cc133fac7935b9d2b
https://doi.org/10.1007/978-1-62703-742-6_30
https://doi.org/10.1007/978-1-62703-742-6_30
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781627037419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a90f1c31e2a5c05c60162574f23f0242
https://doi.org/10.1007/978-1-62703-742-6_29
https://doi.org/10.1007/978-1-62703-742-6_29
Autor:
Jose Silva, Ke Yang, H. Umesha Shetty, Yaodong Xu, Min Yang, Fran Xu, Jie Chen, Heng-Keang Lim, David C. Evans, Wing W. Lam
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 42(8)
Raloxifene was metabolized predominantly by CYP3A4 in human liver microsomes to a pair of carbon-carbon (RD1–2) and ether (RD3–4) linked homodimers in an nicotinamide adenine dinucleotide phosphate-dependent manner. The major homodimer formed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3ae031ed81596fdc9be2e998858686
https://pubmed.ncbi.nlm.nih.gov/22375838
https://pubmed.ncbi.nlm.nih.gov/22375838
Publikováno v:
Mass Spectrometry in Drug Metabolism and Pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b47960851fdeb44614eeb5b80af21fba
https://doi.org/10.1002/9780470409817.ch7
https://doi.org/10.1002/9780470409817.ch7
Autor:
Jonathon N. Bauman, Joan M. Kelly, Sakambari Tripathy, Sabrina X. Zhao, Wing W. Lam, Amit S. Kalgutkar, R. Scott Obach
Publikováno v:
Chemical Research in Toxicology; Feb2009, Vol. 22 Issue 2, p332-340, 9p