Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Wing Ming Keung"'
Autor:
Ivan Diamond, Maria Pia Arolfo, Tao Guoxin, Bert L. Vallee, Louis G. Lange, Justin T. Gass, Wing Ming Keung, Emanuel Rubin, Helen Anni, Brent Blackburn, Clyde W. Hodge, Peidong Fan, David H. Overstreet, Andrew J Lawrence, Lina Yao, Joyce Besheer, Jeff Zablocki, Kwan Leung, M. Foster Olive
Publikováno v:
Alcohol Clin Exp Res
Background: Inherited human aldehyde dehydrogenase 2 (ALDH-2) deficiency reduces the risk for alcoholism. Kudzu plants and extracts have been used for 1,000 years in traditional Chinese medicine to treat alcoholism. Kudzu contains daidzin, which inhi
Autor:
Bernd Mayer, Matteo Beretta, Michael Russwurm, Kurt Schmidt, Wing Ming Keung, Alexander Kollau, Doris Koesling
Publikováno v:
Nitric Oxide. 20:53-60
Reduction of nitrite to nitric oxide (NO) by components of the mitochondrial respiratory chain may link nitroglycerin biotransformation by mitochondrial aldehyde dehydrogenase (ALDH2) to activation of soluble guanylate cyclase (sGC). We used purified
Publikováno v:
Journal of Medicinal Chemistry. 51:4482-4487
The ALDH2*2 gene encoding the inactive variant form of mitochondrial aldehyde dehydrogenase (ALDH2) protects nearly all carriers of this gene from alcoholism. Inhibition of ALDH2 has hence become a possible strategy to treat alcoholism. The natural p
Autor:
Wing Ming Keung, Matteo Beretta, Alexander Kollau, Walter Goessler, Michael Russwurm, Kurt Schmidt, Bernd Mayer, Karl Gruber, Doris Koesling
Publikováno v:
The Journal of Biological Chemistry
Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN bioactivation resulting in cyclic GMP-mediated vascular relaxation. The link between nitrite
Autor:
Joseph J. Schildkraut, David T. Chau, Wing Ming Keung, Alan I. Green, Raquelle I. Mesholam, Ree Dawson
Publikováno v:
Psychiatry Research. 128:9-20
Alcohol abuse contributes substantially to the overall morbidity of schizophrenia. While typical antipsychotic medications do not limit alcohol use in patients with schizophrenia, emerging data suggest that the atypical antipsychotic clozapine does.
Publikováno v:
Brain Research. 1011:243-246
Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor
Autor:
Wing Ming Keung
Publikováno v:
Medicinal Research Reviews. 23:669-696
Daidzin is the active principle of Radix puerariae (RP), an herbal remedy that has been used apparently safely and effectively for the treatment of "alcohol addiction" in China for more than a millennium. It has been shown to reduce alcohol consumpti
Publikováno v:
Alcoholism: Clinical & Experimental Research. 27:177-185
This review summarizes the findings of the effects on alcohol intake in alcohol-preferring rats of extracts or purified compounds from two of the most promising herbs: kudzu (Pueraria lobata) and St. John's Wort (Hypericum perforatum). It is a summar
Autor:
Wing Ming Keung, Yoshifumi Irie
Publikováno v:
Brain Research. 963:282-289
The effects of water extracts of six medicinal herbs (Radix polygalae tenuifoliae, Radix salviae miltiorrhizae, Rhizoma acori graminei, Rhizoma pinelliae ternatae, Tuber curcumae and Scletrotium poriae cocos) on the cytotoxic action of Abeta(1-40) we
Autor:
Wing Ming Keung, Yoshifumi Irie
Publikováno v:
Brain Research. 960:228-234
Recent studies have shown that metallothionein-III (MT-III), but not MT-I or -II, antagonizes both the neurotrophic and neurotoxic effects of amyloid beta peptides (Abetas). Further, its anti-Abeta-toxicity effect was attributed to the fact that it i