Zobrazeno 1 - 10
of 520
pro vyhledávání: '"Wing Kin Sung"'
Autor:
Kuljeet Singh Sandhu, Guoliang Li, Huay Mei Poh, Yu Ling Kelly Quek, Yee Yen Sia, Su Qin Peh, Fabianus Hendriyan Mulawadi, Joanne Lim, Mile Sikic, Francesca Menghi, Anbupalam Thalamuthu, Wing Kin Sung, Xiaoan Ruan, Melissa Jane Fullwood, Edison Liu, Peter Csermely, Yijun Ruan
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1207-1219 (2012)
Chromatin interactions play important roles in transcription regulation. To better understand the underlying evolutionary and functional constraints of these interactions, we implemented a systems approach to examine RNA polymerase-II-associated chro
Externí odkaz:
https://doaj.org/article/e2f6cc497d14497286a90fc278c66109
Autor:
Donglai Sheng, Dianbo Qu, Ken Hon Hung Kwok, Seok Shin Ng, Adrian Yin Ming Lim, Sharon Siqi Aw, Charlie Wah Heng Lee, Wing Kin Sung, Eng King Tan, Thomas Lufkin, Suresh Jesuthasan, Mathavan Sinnakaruppan, Jianjun Liu
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000914 (2010)
LRRK2 plays an important role in Parkinson's disease (PD), but its biological functions are largely unknown. Here, we cloned the homolog of human LRRK2, characterized its expression, and investigated its biological functions in zebrafish. The blockag
Externí odkaz:
https://doaj.org/article/71a4d55173534bceb81193af7008cba3
Autor:
Ramesh Rajaby, Dong-Xu Liu, Chun Hang Au, Yuen-Ting Cheung, Amy Yuet Ting Lau, Qing-Yong Yang, Wing-Kin Sung
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Insertions are one of the major types of structural variations and are defined as the addition of 50 nucleotides or more into a DNA sequence. Several methods exist to detect insertions from next-generation sequencing short read data, but the
Externí odkaz:
https://doaj.org/article/8d6af67baac145ecb61f417e002794aa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Tumors are complex masses composed of malignant and non-malignant cells. Variation in tumor purity (proportion of cancer cells in a sample) can both confound integrative analysis and enable studies of tumor heterogeneity. Here we developed P
Externí odkaz:
https://doaj.org/article/ab8f89b6847d42309ef5bf835a79d5da
Autor:
Wing-Kin Sung
Advances in sequencing technology have allowed scientists to study the human genome in greater depth and on a larger scale than ever before – as many as hundreds of millions of short reads in the course of a few days. But what are the best ways to
Autor:
Qiannan Deng, Cheng Wang, Chwee Tat Koe, Jan Peter Heinen, Ye Sing Tan, Song Li, Cayetano Gonzalez, Wing-Kin Sung, Hongyan Wang
Publikováno v:
PLoS Biology, Vol 20, Iss 10 (2022)
Neural stem cells (NSCs) divide asymmetrically to balance their self-renewal and differentiation, an imbalance in which can lead to NSC overgrowth and tumor formation. The functions of Parafibromin, a conserved tumor suppressor, in the nervous system
Externí odkaz:
https://doaj.org/article/bf49b0e4c14d4019b05b0a6fbf4db8d0
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Esophageal cancer (EC) remains a significant challenge globally, having the 8th highest incidence and 6th highest mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common form of EC in Asia. Crucially, more than 90% of EC cas
Externí odkaz:
https://doaj.org/article/033db0cb18bf4e38bb33e0dcc6408dda
Autor:
Fan Jiang, Yaoxin Jiang, Wenxuan Wang, Changyi Xiao, Ruiyi Lin, Tanghui Xie, Wing-Kin Sung, Shijun Li, Ivan Jakovlić, Jianhai Chen, Xiaoyong Du
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background The Muscovy duck (Cairina moschata) is an economically important duck species, with favourable growth and carcass composition parameters in comparison to other ducks. However, limited genomic resources for Muscovy duck hinder our
Externí odkaz:
https://doaj.org/article/d095cca8698340eb8425609dd542163f
Publikováno v:
Plant Methods, Vol 17, Iss 1, Pp 1-13 (2021)
Abstract Background Peach diseases can cause severe yield reduction and decreased quality for peach production. Rapid and accurate detection and identification of peach diseases is of great importance. Deep learning has been applied to detect peach d
Externí odkaz:
https://doaj.org/article/0b2833e3e2a348c9946e14de07ddb35b
Autor:
Fan Jiang, Ruiyi Lin, Changyi Xiao, Tanghui Xie, Yaoxin Jiang, Jianhai Chen, Pan Ni, Wing-Kin Sung, Jianlin Han, Xiaoyong Du, Shijun Li
Publikováno v:
Genetics Selection Evolution, Vol 53, Iss 1, Pp 1-17 (2021)
Abstract Background The most prolific duck genetic resource in the world is located in Southeast/South Asia but little is known about the domestication and complex histories of these duck populations. Results Based on whole-genome resequencing data o
Externí odkaz:
https://doaj.org/article/926e761fd92640d997f2ca0fb9f7aa69