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Design and synthesis of RNA miniduplexes via a synthetic linker approach. 2. Generation of covalently closed, double-stranded cyclic HIV-1 TAR RNA analogs with high Tat-binding affinity

Autor: Raya Kuperman, Shane C. Climie, Wing C. Lin, Richard W. Barnett, Kirk McCallum, Michael Y.-X. Ma, Martin Sumner-Smith

Publikováno v: Nucleic acids research. 21(11)

We recently developed an approach which allows rapid generation of short, double-stranded oligonucleotides whereby one end of the duplex was joined and stabilized by a synthetic linker of specific design (miniduplexes)(6). Model miniduplexes based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c395044f416a522b1a586a691897331
https://pubmed.ncbi.nlm.nih.gov/8332456

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Design and synthesis of RNA miniduplexes via a synthetic linker approach

Autor: Shane C. Climie, Wing C. Lin, Raya Kuperman, Richard W. Barnett, Martin Sumner-Smith, Lorne S. Reid, Michael Y.-X. Ma

Publikováno v: Biochemistry. 32(7)

Double-stranded oligodeoxyribonucleotides or single-stranded oligoribonucleotides with specific secondary structure have been proposed as potential antagonists to target nucleic acid-binding proteins (the sense approach). A major limitation of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3d5b2d6ceb7f8a33056248f9d6c1af
https://pubmed.ncbi.nlm.nih.gov/7679923

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