Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Winfried Wagner-Redeker"'
Publikováno v:
CHIMIA, Vol 53, Iss 10 (1999)
Ion traps have become an important and powerful tool in many fields of analytical chemistry. The immanent sensitivity of the device and the ability to perform MSn opens a wide variety of experimental setups even at very low sample concentration level
Externí odkaz:
https://doaj.org/article/9d3ccc23496e4dbdb37bd75d343fb47d
Publikováno v:
Journal of Chromatography B. :96-103
A sensitive and selective LC-MS/MS method has been developed to quantify almorexant and its four primary metabolites M3, M5, M6, and M8 in human plasma samples. The method involved protein precipitation with acetonitrile in the high calibration range
Publikováno v:
Drugs in R&D
Background Setipiprant, a tetrahydropyridoindole derivative, is a CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper [Th]-2 cells) antagonist that has the potential to be effective in the treatment of patients with diseases wit
Autor:
Tommaso Miraval, Jasper Dingemanse, Gérard Hopfgartner, Kasra Shakeri-Nejad, Winfried Wagner-Redeker, Alexander Treiber, Matthias Hoch, Petra Hoever
Publikováno v:
Drug Metabolism and Disposition. 41:1046-1059
Almorexant [(2R)-2-{(1S)-6, 7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-1H-isoquinolin-2-yl}-N-methyl-2-phenyl-acetamide], a tetrahydroisoquinoline derivative, is a dual orexin receptor antagonist with sleep-promoting properties in
Autor:
Matthias Hoch, Patrick Brossard, Winfried Wagner-Redeker, Tommaso Miraval, Maribel Reyes, Jasper Dingemanse
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 45(2)
1. Ponesimod [(R)-5-[3-chloro-4-(-2,3-dihydroxy-propoxy)-benzylidene]-2-propylimino-3-o-tolyl-thiazolidin-4-one] is an orally administered, selective S1P1 receptor modulator that blocks the egress of lymphocytes from lymphoid organs and reduces the a
Autor:
Lieve Dillen, Brigitte Buscher, Klaus Pusecker, Philip Timmerman, Winfried Wagner-Redeker, Thomas Pfeifer, Pascal Delrat, Sirpa Laakso, Hermann Mascher, Mira Doig
Publikováno v:
Bioanalysis. 6(5)
Plasma protein binding (PPB) is an important parameter for a drug’s efficacy and safety that needs to be investigated during each drug-development program. Even though regulatory guidance exists to study the extent of PPB before initiating clinical
Publikováno v:
Journal of Mass Spectrometry. 30:940-948
An analytical protocol suggested previously for the mass spectrometric sequence analysis of cyclosporins was extended by addition of methods for discrimination among isobaric amino acids differing either in the nature of the side-chain or N-substitut
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 59
A sensitive liquid chromatography–tandem mass spectrometry method has been developed to quantify miglustat in mouse plasma and in human plasma. The method involved simple protein precipitation with methanol. N-(n-nonyl)deoxynojirimycin was used as
Autor:
Franz Hillenkamp, Winfried Wagner-Redeker, Ralf Hoffmann, Arndt Ingendoh, Renate G. Berger, Louis Maljers, Michael Zeppezauer
Publikováno v:
Journal of chromatography. A. 711(1)
In order to separate and identify histone H1 subtypes from calf thymus we used both electrospray mass spectrometry (ES-MS) and matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF-MS) after a three-step chromatograp
Publikováno v:
The Journal of Physical Chemistry. 89:3269-3273
The results of a laser-ion beam study of the photodissociation of the Kr.CO/sub 2//sup +/ cluster are presented. The photodissociation spectrum, product branching ratios, product angular distributions, and product relative kinetic energy distribution