Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Winfried Neuhaus"'
Autor:
Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M. Cader, Stephen T. Buckley, Irena Loryan, Claus U. Pietrzik
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151406- (2024)
Despite extensive research, targeted delivery of substances to the brain still poses a great challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require either carrier- or receptor-mediated transport systems to reach the
Externí odkaz:
https://doaj.org/article/24cf1f3bfe6c41b79a62e5eaa26fce38
Autor:
Burak Ozgür, Elena Puris, Andreas Brachner, Antje Appelt-Menzel, Sabrina Oerter, Viktor Balzer, Mikkel Roland Holst, Rasmus Folmann Christiansen, Kathrine Hyldig, Stephen T. Buckley, Mie Kristensen, Seppo Auriola, Allan Jensen, Gert Fricker, Morten Schallburg Nielsen, Winfried Neuhaus, Birger Brodin
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Blood-brain barrier (BBB) models based on primary murine, bovine, and porcine brain capillary endothelial cell cultures have long been regarded as robust models with appropriate properties to examine the functional transport of sm
Externí odkaz:
https://doaj.org/article/a725aae18819471b8862ddc5715b995e
Autor:
Mikkel Roland Holst, Nienke Marije de Wit, Burak Ozgür, Andreas Brachner, Kathrine Hyldig, Antje Appelt-Menzel, Hannah Sleven, Zameel Cader, Helga Eveline de Vries, Winfried Neuhaus, Allan Jensen, Birger Brodin, Morten Schallburg Nielsen
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC
Externí odkaz:
https://doaj.org/article/7d4f388528cc44208b95de6aa7348cef
Autor:
Tamara Tal, Oddvar Myhre, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J. Babin, Beate I. Escher, Hubert Dirven, Kati Hellsten, Kristine Dolva, Ellen Hessel, Harm J. Heusinkveld, Yavor Hadzhiev, Selma Hurem, Karolina Jagiello, Beata Judzinska, Nils Klüver, Anja Knoll-Gellida, Britta A. Kühne, Marcel Leist, Malene Lislien, Jan L. Lyche, Ferenc Müller, John K. Colbourne, Winfried Neuhaus, Giorgia Pallocca, Bettina Seeger, Ilka Scharkin, Stefan Scholz, Ola Spjuth, Monica Torres-Ruiz, Kristina Bartmann
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While the public
Externí odkaz:
https://doaj.org/article/84a7889b64d34295a7a44cec97e647b1
Autor:
Undine Haferkamp, Carla Hartmann, Chaudhry Luqman Abid, Andreas Brachner, Alevtina Höchner, Anna Gerhartl, Bernadette Harwardt, Selin Leckzik, Jennifer Leu, Marco Metzger, Marina Nastainczyk-Wulf, Winfried Neuhaus, Sabrina Oerter, Ole Pless, Dan Rujescu, Matthias Jung, Antje Appelt-Menzel
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background The function of the blood-brain barrier (BBB) is impaired in late-onset Alzheimer disease (LOAD), but the associated molecular mechanisms, particularly with respect to the high-risk APOE4/4 genotype, are not well understood. For t
Externí odkaz:
https://doaj.org/article/e79d3dddebfc4e0ba9d9d75350e53843
Autor:
Thomas Däullary, Fabian Imdahl, Oliver Dietrich, Laura Hepp, Tobias Krammer, Christina Fey, Winfried Neuhaus, Marco Metzger, Jörg Vogel, Alexander J. Westermann, Antoine-Emmanuel Saliba, Daniela Zdzieblo
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTInfection research largely relies on classical cell culture or mouse models. Despite having delivered invaluable insights into host-pathogen interactions, both have limitations in translating mechanistic principles to human pathologies. Alter
Externí odkaz:
https://doaj.org/article/4e6314defbf542fa8797bca5587d5316
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 543 (2024)
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most prescribed drugs to treat pain or fever. However, oral administration of NSAIDs is frequently associated with adverse effects due to their inhibitory effect on the constitutively expr
Externí odkaz:
https://doaj.org/article/d5ee176c9cf7490f8221160c9fa69ff5
Autor:
Iva Spreitzer, Josefin Keife, Tobias Strasser, Predrag Kalaba, Jana Lubec, Winfried Neuhaus, Gert Lubec, Thierry Langer, Judith Wackerlig, Irena Loryan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16956 (2023)
S-CE-123, a novel dopamine transporter inhibitor, has emerged as a potential candidate for cognitive enhancement. The objective of this study was to compare the tissue distribution profiles, with a specific focus on central nervous system distributio
Externí odkaz:
https://doaj.org/article/625f0373666f4c3db661f5ba229d286d
Autor:
Nandita Rahatekar Singh, Radka Gromnicova, Andreas Brachner, Igor Kraev, Ignacio A Romero, Winfried Neuhaus, David Male
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283954 (2023)
An in vitro model of the human blood-brain barrier was developed, based on a collagen hydrogel containing astrocytes, overlaid with a monolayer of endothelium, differentiated from human induced pluripotent stem cells (hiPSCs). The model was set up in
Externí odkaz:
https://doaj.org/article/760ca14878c34ccfb65f283bad757fed
Autor:
Martin A. Schick, Jonas Pippir, Manuel F. Struck, Jürgen Brugger, Winfried Neuhaus, Christian Wunder
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Objective Colloid solutions are commonly used to maintain perioperative fluid homeostasis. In regard to perioperative infant-centered care, data about the impact of colloids are rare. New data suggest a possible positive effect of hydroxyeth
Externí odkaz:
https://doaj.org/article/1accb5b2591649c3998785538fb77001