Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Winfried Heyse"'
Autor:
Jian Shen, Jiping Yang, Winfried Heyse, Harald Schweitzer, Norbert Nagel, Doris Andert, Chengyue Zhu, Vincent Morrison, Gregory A. Nemeth, Teng-Man Chen, Zhicheng Zhao, Timothy A. Ayers, Yong-Mi Choi
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Otamixaban is a potent (Ki=0.5Â nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric chara
Externí odkaz:
https://doaj.org/article/e216df50786d432c972e05ee222dd331
Publikováno v:
Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials. 79:122-137
The crystallographic study of two polymorphs of the industrial pyrazolone Pigment Orange 13 (P.O.13) is reported. The crystal structure of the β phase was determined using single-crystal X-ray analysis of a tiny needle. The α phase was investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5642b493eb29e94654f0841a166a29d
https://doi.org/10.1107/s2052520623000720
https://doi.org/10.1107/s2052520623000720
Autor:
Harald Berchtold, Melissa A. Graewert, Winfried Heyse, Cy M. Jeffries, Mimi Gao, Dmitri I. Svergun, Norbert Nagel
Publikováno v:
Biophysical chemistry. 253
The quaternary structures of insulin glargine and glulisine under formulation conditions and upon dilution using placebo or water were investigated using synchrotron small-angle X-ray scattering. Our results revealed that insulin glulisine in Apidra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ef4b0122b5eb0589c2e0060a90193c
https://pubmed.ncbi.nlm.nih.gov/31376619
https://pubmed.ncbi.nlm.nih.gov/31376619
Autor:
Petra Arndt, Thomas Maier, John Weston, Nils Rackelmann, Katharina Mertsch, Heinrich Christian Englert, Hans Matter, Winfried Heyse, Markus Follmann, Klaus Wirth, Laurent Bialy
Publikováno v:
Journal of Medicinal Chemistry. 59:8812-8829
The design, synthesis, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na+/H+ exchanger type 3 (NHE3) are described based on a hit from high-throughput screening (HTS). The chemical optimization resulted in the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b71b68b14e8ff85d15f311b1a3b4d0d
https://doi.org/10.1021/acs.jmedchem.6b00624
https://doi.org/10.1021/acs.jmedchem.6b00624
Autor:
Michael Caspers, Dietmar Schummer, Hans Matter, Mark Brönstrup, Christine Klemke-Jahn, Holger Hoffmann, Armin Bauer, Winfried Heyse, Herbert Kogler, Geraldine Penarier, Laurent Debussche
Publikováno v:
Angewandte Chemie. 127:10283-10286
Microbial natural products are a rich source of bioactive molecules to serve as drug leads and/or biological tools. We investigated a little-explored myxobacterial genus, Nannocystis sp., and discovered a novel 21-membered macrocyclic scaffold that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32297de3c4dbafb3e73e7712437a847c
https://doi.org/10.1002/ange.201411377
https://doi.org/10.1002/ange.201411377
Autor:
Jiping Yang, Jian Shen, Winfried Heyse, Doris Andert, Harald Schweitzer, Chengyue Zhu, Gregory A. Nemeth, Yong-Mi Choi, Zhicheng Zhao, Timothy A. Ayers, Vincent Morrison, Teng-Man Chen, Norbert Nagel
Publikováno v:
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Otamixaban is a potent (Ki=0.5Â nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286fd0572070c3d598a63939b6535cd2
Autor:
Nils, Rackelmann, Hans, Matter, Heinrich, Englert, Markus, Follmann, Thomas, Maier, John, Weston, Petra, Arndt, Winfried, Heyse, Katharina, Mertsch, Klaus, Wirth, Laurent, Bialy
Publikováno v:
Journal of medicinal chemistry. 59(19)
The design, synthesis, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29af6020d87fc3185c699ff0a949d9ef
https://pubmed.ncbi.nlm.nih.gov/27606885
https://pubmed.ncbi.nlm.nih.gov/27606885
Autor:
Martin Gerlitz, Serge Sablé, Joachim Wink, Antje Nußer, Helene Olivan, Winfried Heyse, Herbert Kogler, Mark Brönstrup, Astrid Rey, Cedric Couturier, Luigi Toti, Michael Kurz, Armin Bauer, Cosima Dufour
Publikováno v:
Chemistry - A European Journal. 18:16123-16128
In an antibiotic lead discovery program, the known strain Streptomyces armeniacus DSM19369 has been found to produce three new natural products when cultivated on a malt-containing medium. The challenging structural elucidation of the isolated compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71c7729e7d096b9ba3feafd05170fa6
https://doi.org/10.1002/chem.201201635
https://doi.org/10.1002/chem.201201635
Autor:
Martin U. Schmidt, Jaroslav Teteruk, Winfried Heyse, Jürgen Glinnemann, Kristoffer E. Johansson, Jacco van de Streek
Publikováno v:
Acta crystallographica Section B, Structural science, crystal engineering and materials. 72(Pt 3)
Thecis- andtrans-isomers of the polycyclic aromatic compound perinone, C26H12N4O2, form a solid solution (Vat Red 14). This solid solution is isotypic to the crystal structures ofcis-perinone (Pigment Red 194) andtrans-perinone (Pigment Orange 34) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40e63149cf3bfa656ee3843cd96ac7c
https://pubmed.ncbi.nlm.nih.gov/27240774
https://pubmed.ncbi.nlm.nih.gov/27240774
Autor:
Jörg Jurascheck, Christine Petzoldt, Thomas Olpp, Lydia Helmdach, Bruno Baumgartner, Martin P. Feth, Joachim Ulrich, Christoph Tappertzhofen, Norbert Nagel, Winfried Heyse
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 83(3)
The solid-state development for the low dose drug molecule SAR114137, a selective and reversible inhibitor of cysteine cathepsin S/K, is reported. Six polymorphic forms as well as various solvate phases were discovered by an extensive polymorphism sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f777b985a3fb2be27a370a88712370f6
https://pubmed.ncbi.nlm.nih.gov/23201054
https://pubmed.ncbi.nlm.nih.gov/23201054