Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Winfried G J Degen"'
Publikováno v:
Immunopotentiators in Modern Vaccines: Second Edition
Immunopotentiators in Modern Vaccines: Second Edition. Elsevier
Immunopotentiators in Modern Vaccines: Second Edition. Elsevier
The increased knowledge about immunological concepts and systems nowadays helps to rationally enhance the performance of, and to overcome some of the problems, that are associated with inactivated vaccines. Because the antigenic component of an inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d064e45ae39e0dff7b015eb4966c7e
https://doi.org/10.1016/b978-0-12-804019-5.00004-9
https://doi.org/10.1016/b978-0-12-804019-5.00004-9
Publikováno v:
Clinical Pharmacology & Therapeutics. 82:750-755
Vaccine adjuvants or immunopotentiators comprise a diverse group of molecules or formulations. Despite a wealth of different candidates, there is a need for better vaccine adjuvants in both veterinary and human medicine. For human vaccines, the immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3db68b62b067d5e0f83980d88eedf45
https://doi.org/10.1038/sj.clpt.6100394
https://doi.org/10.1038/sj.clpt.6100394
Autor:
Dave Burt, Jacqueline Smith, Virgil E.J.C. Schijns, Bartjan Simmelink, Elizabeth Glass, Winfried G J Degen
Publikováno v:
Degen, W G J, Smith, J, Simmelink, B, Glass, E J, Burt, D W & Schijns, V E J C 2006, ' Molecular immunophenotyping of lungs and spleens in naive and vaccinated chickens early after pulmonary avian influenza A (H9N2) virus infection ', Vaccine, vol. 24, no. 35-36, pp. 6096-109 . https://doi.org/10.1016/j.vaccine.2006.05.027
In a respiratory-infection-model with the avian influenza A H9N2 virus we studied lung and splenic immune reactions in chickens using a recently developed 5K chicken immuno-microarray. Groups of chickens were either mock-immunized (referred to as non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6168d9b0e53b8643c92bdf3d5b8b5c9
https://doi.org/10.1016/j.vaccine.2006.05.027
https://doi.org/10.1016/j.vaccine.2006.05.027
Autor:
Virgil E.J.C. Schijns, Joan Burnside, Nancy van Daal, Winfried G J Degen, Hanneke I. van Zuilekom
Publikováno v:
The Journal of Immunology. 172:4371-4380
By a combination of large-scale sequencing, bioinformatics, and traditional molecular biology, we identified the long-searched-for cDNA sequences encoding the homologues of the chicken IL-12p35 and IL-12p40 chains. These molecules are the first disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b94aba1cd3d29d074fc73821595443
https://doi.org/10.4049/jimmunol.172.7.4371
https://doi.org/10.4049/jimmunol.172.7.4371
Publikováno v:
Expert Review of Vaccines. 2:327-335
Distinct types of immune responses are required for efficient elimination of different pathogens. Programming of the desired type of immune response by safe nonreplicating vaccines requires suitable vaccine adjuvants. Adjuvants largely determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723f4a92ce25cb9a47265d36df73d71d
https://doi.org/10.1586/14760584.2.2.327
https://doi.org/10.1586/14760584.2.2.327
Autor:
Marian J. A. Groot Koerkamp, Peter M. van de Haar, Christine A. Jansen, Willem van Eden, Daphne A. van Haarlem, Winfried G J Degen, Sylvia S. Reemers, Lonneke Vervelde
Publikováno v:
Reemers, S S, Jansen, C, Koerkamp, M J G, van Haarlem, D, van de Haar, P, Degen, W G J, van Eden, W & Vervelde, L 2010, ' Reduced immune reaction prevents immunopathology after challenge with avian influenza virus: A transcriptomics analysis of adjuvanted vaccines ', Vaccine, vol. 28, no. 38, pp. 6351-6360 . https://doi.org/10.1016/j.vaccine.2010.06.099
Vaccine, 28(38), 6351-6360
Vaccine 28 (2010) 38
Vaccine, 28(38), 6351-6360
Vaccine 28 (2010) 38
To gain more insight in underlying mechanisms correlating to protection against avian influenza virus (AIV) infection, we investigated correlates of protection after AIV H9N2 infection and studied the contribution of different adjuvants to a protecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a53e6a7d14a383e2472f903091cb1d3
https://pubmed.ncbi.nlm.nih.gov/20637308
https://pubmed.ncbi.nlm.nih.gov/20637308
Autor:
David W. Burt, Paul M Hocking, Richard Talbot, Jacqueline Smith, Virgil E.J.C. Schijns, David Speed, Elizabeth Glass, Winfried G J Degen
Publikováno v:
BMC Genomics
BMC Genomics, Vol 7, Iss 1, p 49 (2006)
Smith, J, Speed, D, Hocking, P M, Talbot, R T, Degen, W G J, Schijns, V E J C, Glass, E J & Burt, D W 2006, ' Development of a chicken 5 K microarray targeted towards immune function ', BMC Genomics, vol. 7, 49, pp. 49 . https://doi.org/10.1186/1471-2164-7-49
BMC Genomics, Vol 7, Iss 1, p 49 (2006)
Smith, J, Speed, D, Hocking, P M, Talbot, R T, Degen, W G J, Schijns, V E J C, Glass, E J & Burt, D W 2006, ' Development of a chicken 5 K microarray targeted towards immune function ', BMC Genomics, vol. 7, 49, pp. 49 . https://doi.org/10.1186/1471-2164-7-49
Background The development of microarray resources for the chicken is an important step in being able to profile gene expression changes occurring in birds in response to different challenges and stimuli. The creation of an immune-related array is hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3191704d36e29a21e720a8d88b1875bf
https://doi.org/10.1186/1471-2164-7-49
https://doi.org/10.1186/1471-2164-7-49
Publikováno v:
Degen, W G J, Daal, N V, Rothwell, L, Kaiser, P & Schijns, V E J C 2005, ' Th1/Th2 polarization by viral and helminth infection in birds ', Veterinary Microbiology, vol. 105, no. 3-4, pp. 163-7 . https://doi.org/10.1016/j.vetmic.2004.12.001
Mammals developed an immune system able to functionally polarize into so-called type 1 or type 2 immune pathways, to resolve infections with intracellular and extracellular pathogens, respectively. In the well-studied avian immune system of the chick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6769d1c985b69f18b0bb4225c587c866
https://hdl.handle.net/20.500.11820/aafe8ee9-2eed-441c-a30e-4b67a17eceb6
https://hdl.handle.net/20.500.11820/aafe8ee9-2eed-441c-a30e-4b67a17eceb6
Potentiation of humoral immune responses to vaccine antigens by recombinant chicken IL-18 (rChIL-18)
Autor:
Nicolette C Scholtes, Winfried G J Degen, Virgil E.J.C. Schijns, Hanneke I. van Zuilekom, Nancy van Daal
Publikováno v:
Vaccine. 23(33)
Mammalian interleukin-18 (IL-18) is one of the pro-inflammatory cytokines involved in innate immune responses to microbial infection preceding the induction of both cellular and humoral immune responses. We assessed the potential of Escherichia coli-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c7f797f21f0b703f72aa0543a96515
https://pubmed.ncbi.nlm.nih.gov/15919141
https://pubmed.ncbi.nlm.nih.gov/15919141