Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Winfried F Pickl"'
Autor:
Sylvia Kerschbaum-Gruber, Ava Kleinwächter, Katerina Popova, Alexandra Kneringer, Lisa-Marie Appel, Katharina Stasny, Anna Röhrer, Ana Beatriz Dias, Johannes Benedum, Lena Walch, Andreas Postl, Sandra Barna, Bernhard Kratzer, Winfried F. Pickl, Altuna Akalin, Filip Horvat, Vedran Franke, Joachim Widder, Dietmar Georg, Dea Slade
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths worldwide with limited treatment options due to extensive radiation and chemotherapy resistance. Monotherapy with immune checkpoint blockade showed n
Externí odkaz:
https://doaj.org/article/3025e223cab047d6828e139b1e21af01
Autor:
Daniela Wojta-Stremayr, Alina Neunkirchner, Bharani Srinivasan, Doris Trapin, Klaus G Schmetterer, Winfried F Pickl
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126034 (2015)
A variety of adjuvants fostering humoral immunity are known as of today. However, there is a lack of adjuvants or adjuvant strategies, which directly target T cellular effector functions and memory. We here determined whether systemically toxic cytok
Externí odkaz:
https://doaj.org/article/4de183e7019949d7adf27ab9f66b0640
Autor:
Judith Leitner, Armin Rieger, Winfried F Pickl, Gerhard Zlabinger, Katharina Grabmeier-Pfistershammer, Peter Steinberger
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003253 (2013)
T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and galectin-9 was describe
Externí odkaz:
https://doaj.org/article/2a7b657d126845cc98b7f561078c75ce
Autor:
Armin Kraus, Bernhard Kratzer, Al Nasar Ahmed Sehgal, Doris Trapin, Matarr Khan, Nicole Boucheron, Winfried F. Pickl
Publikováno v:
Vaccines, Vol 12, Iss 7, p 797 (2024)
Virus-like nanoparticles (VNP) are regarded as efficient vaccination platforms and have proven to be useful for the non-anaphylactogenic delivery of allergen-specific immunotherapy in preclinical models previously. Herein, we sought to determine the
Externí odkaz:
https://doaj.org/article/d2ba35f4682a4fb4aaf38d4bc193e210
Autor:
Al Nasar Ahmed Sehgal, Jera Safran, Bernhard Kratzer, Pia Gattinger, Robert B. Stieger, Laszlo Musiejovsky, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Thomas Perkmann, Ursula Wiedermann, Rudolf Valenta, Winfried F. Pickl
Publikováno v:
Vaccines, Vol 12, Iss 4, p 377 (2024)
Background: COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has now become endemic and is currently one of the important respiratory virus infections regularly affecting mankind. The assessment of immunity against SA
Externí odkaz:
https://doaj.org/article/a38095d367404c3492f620969ca500df
Autor:
Erika Garner-Spitzer, Angelika Wagner, Venugopal Gudipati, Anna-Margarita Schoetta, Maria Orola-Taus, Michael Kundi, Renate Kunert, Patrick Mayrhofer, Johannes B. Huppa, Hannes Stockinger, Rita Carsetti, Pia Gattinger, Rudolf Valenta, Bernhard Kratzer, Al Nasar Ahmed Sehgal, Winfried F. Pickl, Walter Reinisch, Gottfried Novacek, Ursula Wiedermann
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104788- (2023)
Summary: Background: Patients with inflammatory bowel disease (IBD) and healthy controls received primary SARS-CoV-2-mRNA vaccination and a booster after six months. Anti-TNF-α-treated patients showed significantly lower antibody (Ab) levels and fas
Externí odkaz:
https://doaj.org/article/af0e7bd0d2944b3bb222d123ec80fe21
Autor:
Pia Gattinger, Bernhard Kratzer, Al Nasar Ahmed Sehgal, Anna Ohradanova-Repic, Laura Gebetsberger, Gabor Tajti, Margarete Focke-Tejkl, Mirjam Schaar, Verena Fuhrmann, Lukas Petrowitsch, Walter Keller, Sandra Högler, Hannes Stockinger, Winfried F. Pickl, Rudolf Valenta
Publikováno v:
Vaccines, Vol 12, Iss 3, p 229 (2024)
Background: COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a recurrent endemic disease affecting the whole world. Since November 2021, Omicron and its subvariants have dominated in the spread of the d
Externí odkaz:
https://doaj.org/article/9bb6c13b42394d98b525c6240c46ea2e
Autor:
Peter A. Tauber, Bernhard Kratzer, Philipp Schatzlmaier, Ursula Smole, Cordula Köhler, Lisa Rausch, Jan Kranich, Doris Trapin, Alina Neunkirchner, Maja Zabel, Sabrina Jutz, Peter Steinberger, Gabriele Gadermaier, Thomas Brocker, Hannes Stockinger, Sophia Derdak, Winfried F. Pickl
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundTreg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activation of T lymphocytes has been demonstrated to critically participate in Treg development.Objecti
Externí odkaz:
https://doaj.org/article/00251fce79eb4bce8c93560542f17e14
Autor:
Nina Worel, Katharina Grabmeier-Pfistershammer, Bernhard Kratzer, Martina Schlager, Andreas Tanzmann, Arno Rottal, Ulrike Körmöczi, Edit Porpaczy, Philipp B. Staber, Cathrin Skrabs, Harald Herkner, Venugopal Gudipati, Johannes B. Huppa, Benjamin Salzer, Manfred Lehner, Nora Saxenhuber, Eleonora Friedberg, Philipp Wohlfarth, Georg Hopfinger, Werner Rabitsch, Ingrid Simonitsch-Klupp, Ulrich Jäger, Winfried F. Pickl
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
BackgroundChimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. Despite this het
Externí odkaz:
https://doaj.org/article/b9b90c9752894772a6c70577e2f23cde
Autor:
Anita Lawitschka, Leila Ronceray, Dorothea Bauer, Michael Rittenschober, Natalia Zubarovskaya, Rene Geyeregger, Winfried F. Pickl, Zoya Kuzmina
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Objectives: Chronic graft-versus-host disease (cGvHD) following haematopoietic stem cell transplantation (HSCT) shares many similarities with de novo autoimmune disorders, being associated with the presence of autoantibodies. However, data on the imp
Externí odkaz:
https://doaj.org/article/42f9045f8f9542928c41f898230a2cfa