Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Winfried, Weissenhorn"'
Autor:
Haiyan Wang, Benoit Gallet, Christine Moriscot, Mylène Pezet, Christine Chatellard, Jean-Philippe Kleman, Heinrich Göttlinger, Winfried Weissenhorn, Cécile Boscheron
Publikováno v:
Viruses, Vol 15, Iss 12, p 2289 (2023)
HIV-1 budding as well as many other cellular processes require the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. Understanding the architecture of the native ESCRT-III complex at HIV-1 budding sites is limited due to spatial res
Externí odkaz:
https://doaj.org/article/a113441508aa4228b3cb3d0ef545d6fe
Autor:
Maryam Alqabandi, Nicola de Franceschi, Sourav Maity, Nolwenn Miguet, Marta Bally, Wouter H. Roos, Winfried Weissenhorn, Patricia Bassereau, Stéphanie Mangenot
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical
Externí odkaz:
https://doaj.org/article/5a1cea2ff9f246fd85b8db99a2e2f19c
Publikováno v:
Viruses, Vol 15, Iss 2, p 558 (2023)
The SARS-CoV-2 pandemic has again shown that structural biology plays an important role in understanding biological mechanisms and exploiting structural data for therapeutic interventions. Notably, previous work on SARS-related glycoproteins has pave
Externí odkaz:
https://doaj.org/article/ee41b50dc1b54fb7bc4c964674a4a37c
Autor:
Aurélie Bertin, Nicola de Franceschi, Eugenio de la Mora, Sourav Maity, Maryam Alqabandi, Nolwen Miguet, Aurélie di Cicco, Wouter H. Roos, Stéphanie Mangenot, Winfried Weissenhorn, Patricia Bassereau
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear. Here authors use structural and biophysical methods to show how human ESCR
Externí odkaz:
https://doaj.org/article/aa5a1cbf4c8c4f8ebe1df35bf137441a
Autor:
Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn
Publikováno v:
eLife, Vol 10 (2021)
The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specifi
Externí odkaz:
https://doaj.org/article/c1f8eb01d322414cb7d10e348e2d38dc
Autor:
Kimi Azad, Delphine Guilligay, Cecile Boscheron, Sourav Maity, Nicola De Franceschi, Guidenn Sulbaran, Gregory Effantin, Haiyan Wang, Jean-Philippe Kleman, Patricia Bassereau, Guy Schoehn, Wouter H. Roos, Ambroise Desfosses, Winfried Weissenhorn
Publikováno v:
Nature Structural and Molecular Biology, 30, 81-90. Nature Publishing Group
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2022, 30 (1), pp.81-90. ⟨10.1038/s41594-022-00867-8⟩
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2022, 30 (1), pp.81-90. ⟨10.1038/s41594-022-00867-8⟩
International audience; The endosomal sorting complex required for transport (ESCRT) is a highly conserved protein machinery that drives a divers set of physiological and pathological membrane remodeling processes. However, the structural basis of ES
Autor:
Alexandra Hauser, George Carnell, Kathrin Held, Guidenn Sulbaran, Nadine Tischbierek, Lisa Rogers, Georgios Pollakis, Paul Tonks, Michael Hoelscher, Song Ding, Rogier W. Sanders, Christof Geldmacher, Quentin Sattentau, Winfried Weissenhorn, Jonathan L. Heeney, David Peterhoff, Ralf Wagner
Publikováno v:
Vaccines, Vol 9, Iss 7, p 750 (2021)
Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn, will most likely be a pr
Externí odkaz:
https://doaj.org/article/f2bd631258a341ecae7f40d4d3f6c454
Publikováno v:
Bio-Protocol, Vol 9, Iss 13 (2019)
In vitro investigation of the interaction between proteins and positively curved membranes can be performed using a classic nanotube pulling method. However, characterizing protein interaction with negatively curved membranes still represents a formi
Externí odkaz:
https://doaj.org/article/9eb79f00c91c47a6bf1716f06abbd6c2
Publikováno v:
Viruses, Vol 12, Iss 11, p 1210 (2020)
HIV-1 vaccine research has obtained an enormous boost since the discovery of many broadly neutralizing antibodies (bnAbs) targeting all accessible sites on the HIV-1 envelope glycoprotein (Env). This in turn facilitated high-resolution structures of
Externí odkaz:
https://doaj.org/article/fdf85a1e9e054c7c87277dadd688dbf6
Autor:
Jodie Lopez, Amina Bittame, Céline Massera, Virginie Vasseur, Grégory Effantin, Anne Valat, Célia Buaillon, Sophie Allart, Barbara A. Fox, Leah M. Rommereim, David J. Bzik, Guy Schoehn, Winfried Weissenhorn, Jean-François Dubremetz, Jean Gagnon, Corinne Mercier, Marie-France Cesbron-Delauw, Nicolas Blanchard
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2273-2286 (2015)
Apicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their parasitophorous vacuole (PV), resulting in host cell subversion and potential presentation by MHC class I molecules for CD8 T cell recognition. The h
Externí odkaz:
https://doaj.org/article/bed759afc9704f54bdc70e40d2319003