Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Winfried, Denk"'
Autor:
Fabian Svara, Dominique Förster, Fumi Kubo, Michał Januszewski, Marco dal Maschio, Philipp J. Schubert, Jörgen Kornfeld, Adrian A. Wanner, Eva Laurell, Winfried Denk, Herwig Baier
Publikováno v:
Nature Methods
This Resource presents a serial block-face EM dataset of the whole larval zebrafish brain, including automated segmentation of neurons, detection of synapses and reconstruction of circuitry for visual motion processing. Dense reconstruction of synapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e242bd6f13c99321ac80e3c690ee79c4
https://doi.org/10.1038/s41592-022-01621-0
https://doi.org/10.1038/s41592-022-01621-0
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207828 (2018)
With the advent of neurogenetic methods, the neural basis of behavior is presently being analyzed in more and more detail. This is particularly true for visually driven behavior of Drosophila melanogaster where cell-specific driver lines exist that,
Externí odkaz:
https://doaj.org/article/7034e1df3aaf45eda0376cb4c645b8d0
Publikováno v:
eLife, Vol 6 (2017)
We present an approach to study macromolecular assemblies by detecting component proteins’ characteristic high-resolution projection patterns, calculated from their known 3D structures, in single electron cryo-micrographs. Our method detects single
Externí odkaz:
https://doaj.org/article/f8c83cfd4fdb433e8e882d9efaf767e1
Autor:
Jörgen Kornfeld, Sam E Benezra, Rajeevan T Narayanan, Fabian Svara, Robert Egger, Marcel Oberlaender, Winfried Denk, Michael A Long
Publikováno v:
eLife, Vol 6 (2017)
The sequential activation of neurons has been observed in various areas of the brain, but in no case is the underlying network structure well understood. Here we examined the circuit anatomy of zebra finch HVC, a cortical region that generates sequen
Externí odkaz:
https://doaj.org/article/db1a2f639d9d4eb4954e2199000f37b5
Autor:
Edward M. Callaway, Gerald M. Rubin, Kristen M. Harris, Larry F. Abbott, Yann LeCun, Catherine Dulac, Narayanan Kasthuri, Liqun Luo, David W. Tank, R. Clay Reid, Davi D. Bock, David C. Van Essen, H. Sebastian Seung, Ila Fiete, Winfried Denk, Peter B. Littlewood, Karel Svoboda, Adrienne L. Fairhall, John H. R. Maunsell, Moritz Helmstaedter, Terrence J. Sejnowski, Viren Jain, Bruce R. Rosen, Doris Y. Tsao, Jeff W. Lichtman
Publikováno v:
Cell
Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the same data-rich sources. Advances in automated mapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e4a2ab7463282265b218873deea6c6
https://pubmed.ncbi.nlm.nih.gov/32946777
https://pubmed.ncbi.nlm.nih.gov/32946777
A general method to map molecular interactions and conformational states in structurally intact cells would find wide application in biochemistry and cell biology. We used a library of images— calculated on the basis of known structural data—as s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda85fc582d4455113f32f1020d6062c
https://doi.org/10.1101/2020.04.22.053868
https://doi.org/10.1101/2020.04.22.053868
Autor:
Jörgen Kornfeld, Viren Jain, Winfried Denk, Michale S. Fee, Philipp J Schubert, Michał Januszewski
Learning turns experience into better decisions. A key problem in learning is credit assignment—knowing how to change parameters, such as synaptic weights deep within a neural network, in order to improve behavioral performance. Artificial intellig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ce59feba0f30b75773b9247dea0145
https://doi.org/10.1101/2020.02.18.954354
https://doi.org/10.1101/2020.02.18.954354
Publikováno v:
PLoS Biology, Vol 5, Iss 7, p e185 (2007)
Detection of image motion direction begins in the retina, with starburst amacrine cells (SACs) playing a major role. SACs generate larger dendritic Ca(2+) signals when motion is from their somata towards their dendritic tips than for motion in the op
Externí odkaz:
https://doaj.org/article/953e2aa2fc824273b60b8178a43629cb
Publikováno v:
PLoS Pathogens, Vol 2, Iss 8, p e85 (2006)
Herpesviruses are large double-stranded DNA viruses that replicate in the nuclei of infected cells. Spatial control of viral replication and assembly in the host nucleus is achieved by the establishment of nuclear compartments that serve to concentra
Externí odkaz:
https://doaj.org/article/3a3739bf01c4415db7319a6f526a7216
Autor:
Mazahir T Hasan, Rainer W Friedrich, Thomas Euler, Matthew E Larkum, Günter Giese, Matthias Both, Jens Duebel, Jack Waters, Hermann Bujard, Oliver Griesbeck, Roger Y Tsien, Takeharu Nagai, Atsushi Miyawaki, Winfried Denk
Publikováno v:
PLoS Biology, Vol 2, Iss 6, p e163 (2004)
Genetically encoded fluorescent calcium indicator proteins (FCIPs) are promising tools to study calcium dynamics in many activity-dependent molecular and cellular processes. Great hopes-for the measurement of population activity, in particular-have t
Externí odkaz:
https://doaj.org/article/9a38fc2896594d508a210d9ddadce15e