De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.

Autor: Roy A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Shi L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Encodia Inc, 5785 Oberlin Drive, San Diego, CA, 92121, USA., Chang A; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Dong X; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA.; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, Nanjing, China., Fernandez A; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Kraft JC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Li J; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA., Le VQ; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA., Winegar RV; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Cherf GM; Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.; Denali Therapeutics, South San Francisco, CA, USA., Slocum D; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA., Poulson PD; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Casper GE; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Vallecillo-Zúniga ML; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Valdoz JC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Miranda MC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Bai H; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Kipnis Y; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA., Olshefsky A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA., Priya T; Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Carter L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Ravichandran R; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Chow CM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Johnson MR; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Cheng S; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Smith M; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Overed-Sayer C; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Finch DK; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Alchemab Therapeutics Ltd, Cambridge, UK., Lowe D; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Evox Therapeutics Limited, Oxford Science Park, Medawar Centre, East Building, Robert Robinson Avenue, Oxford, OX4 4HG, England., Bera AK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Matute-Bello G; Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, USA., Birkland TP; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA., DiMaio F; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Raghu G; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.; Dept of Medicine, University of Washington, Seattle, WA, USA., Cochran JR; Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA., Stewart LJ; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Campbell MG; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA. melody@fredhutch.org., Van Ry PM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA. pvanry@byu.edu., Springer T; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA. springer@crystal.harvard.edu., Baker D; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA. dabaker@uw.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 13; Vol. 14 (1), pp. 5660. Date of Electronic Publication: 2023 Sep 13.