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De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.

Autor: Roy A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Shi L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Current Address: Encodia Inc, 5785 Oberlin Drive, San Diego, CA 92121., Chang A; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Dong X; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States.; Current address: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China; Engineering Research Center of Protein and Peptide Medicine，Ministry of Education., Fernandez A; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Kraft JC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Li J; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States., Le VQ; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States., Winegar RV; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Cherf GM; Department of Bioengineering, Stanford University, Stanford CA 94305.; Current Address: Denali Therapeutics, South San Francisco, CA, USA., Slocum D; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Daniel Poulson P; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Casper GE; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Vallecillo-Zúniga ML; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Valdoz JC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Miranda MC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Current Address: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Bai H; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Kipnis Y; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington., Olshefsky A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Priya T; Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.; Current Address: Department of Pharmacology, Northwestern University Feinberg School of Medicine; Chicago, IL 60611, USA., Carter L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ravichandran R; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Chow CM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Johnson MR; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Cheng S; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Smith M; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Overed-Sayer C; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Current Address: Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Finch DK; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Current Address: Alchemab Therapeutics Ltd, Cambridge, United Kingdom., Lowe D; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Current Address: Evox Therapeutics Limited, Oxford Science Park, Medawar Centre, East Building, Robert Robinson Avenue, Oxford, OX4 4HG., Bera AK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Matute-Bello G; Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington., Birkland TP; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington., DiMaio F; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Raghu G; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington., Cochran JR; Department of Bioengineering, Stanford University, Stanford CA 94305., Stewart LJ; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Campbell MG; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Van Ry PM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Springer T; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States., Baker D; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 12. Date of Electronic Publication: 2023 Jun 12.