Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Winder B. Perez"'
Autor:
Kelley R. Healey, Yanan Zhao, Winder B. Perez, Shawn R. Lockhart, Jack D. Sobel, Dimitrios Farmakiotis, Dimitrios P. Kontoyiannis, Dominique Sanglard, Saad J. Taj-Aldeen, Barbara D. Alexander, Cristina Jimenez-Ortigosa, Erika Shor, David S. Perlin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The fungal pathogen Candida glabrata readily acquires resistance to multiple types of antifungal drugs. Here, Healey et al. show that C. glabrataclinical isolates often carry mutations in a gene involved in DNA mismatch repair, and this is associated
Externí odkaz:
https://doaj.org/article/1815c031c89a4873a9003da52493606b
Autor:
David S. Perlin, Grayson Hough, Yanan Zhao, Ken Bartizal, Winder B. Perez, Cristina Jiménez-Ortigosa, Voon Ong, Jeffrey B. Locke
Publikováno v:
Cellular Microbiology
Summary CD101 is a novel echinocandin drug being developed to treat severe fungal infections including invasive candidiasis. We have performed a series of studies to evaluate the antifungal properties of CD101 against both echinocandin‐susceptible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02381a4b616214142a518d995d49de81
https://doi.org/10.1111/cmi.12640
https://doi.org/10.1111/cmi.12640
Autor:
Kelley R. Healey, David S. Perlin, Winder B. Perez, Muna Almaslamani, Mary Motyl, Saad J. Taj-Aldeen, Atqah AbdulWahab, Husam M. Salah
A total of 301 Candida bloodstream isolates collected from 289 patients over 5 years at a tertiary hospital in Qatar were evaluated. Out of all Candida infections, 53% were diagnosed in patients admitted to the intensive care units. Steady increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ade5346a32f97ea58613489815da1c
https://europepmc.org/articles/PMC6125493/
https://europepmc.org/articles/PMC6125493/
Autor:
Katyna Borroto-Esoda, David S. Perlin, Cristina Jiménez-Ortigosa, Winder B. Perez, David Angulo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
SCY-078 is an orally active antifungal whose target is the β-(1,3)- d -glucan synthase (GS). We evaluated the spontaneous emergence of SCY-078-resistant Candida glabrata isolates following drug exposure in vitro . Resistant isolates were analyzed us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a82aaab4858a85572196b6e18ce83c5
https://doi.org/10.1128/aac.00833-17
https://doi.org/10.1128/aac.00833-17
Autor:
Terri Goss Kinzy, Winder B. Perez
Publikováno v:
Journal of Biological Chemistry. 289:20928-20938
Apart from its canonical function in translation elongation, eukaryotic translation elongation factor 1A (eEF1A) has been shown to interact with the actin cytoskeleton. Amino acid substitutions in eEF1A that reduce its ability to bind and bundle acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c649f1f4b444e395aa726cba8593e4
https://doi.org/10.1074/jbc.m114.570077
https://doi.org/10.1074/jbc.m114.570077
Autor:
David S. Perlin, Yanan Zhao, Dimitrios Farmakiotis, Shawn R. Lockhart, Dimitrios P. Kontoyiannis, Jack D. Sobel, Barbara D. Alexander, Winder B. Perez, Dominique Sanglard, Erika Shor, Saad J. Taj-Aldeen, Cristina Jiménez-Ortigosa, Kelley R. Healey
Publikováno v:
Nature Communications, vol. 7, pp. 11128
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins. Thus far, cellular mechanisms promoting the emergence of resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a40860f10193fc2a5f4ddda277a82fd
https://serval.unil.ch/notice/serval:BIB_55BE139CDF92
https://serval.unil.ch/notice/serval:BIB_55BE139CDF92
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 3:543-555
The vast majority of proteins are believed to have one specific function. Throughout the course of evolution, however, some proteins have acquired additional functions to meet the demands of a complex cellular milieu. In some cases, changes in RNA or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bbdd74ad8e0eea31b06091c14e7d44
https://doi.org/10.1002/wrna.1118
https://doi.org/10.1002/wrna.1118
Autor:
Terri Goss Kinzy, Winder B. Perez
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0731d9aeef85507b5bfc9d6f1d6d852d
https://doi.org/10.1096/fasebj.27.1_supplement.986.2
https://doi.org/10.1096/fasebj.27.1_supplement.986.2