Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system

Autor: Gadgaard, Sarina, Windeløv, Johanne A., Schiellerup, Sine P., Holst, Jens J., Hartmann, Bolette, Rosenkilde, Mette M.

Publikováno v: In Biomedicine & Pharmacotherapy April 2023 160

Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis

Autor: Winther-Sørensen, Marie, Galsgaard, Katrine D., Santos, Alberto, Trammell, Samuel A.J., Sulek, Karolina, Kuhre, Rune E., Pedersen, Jens, Andersen, Daniel B., Hassing, Anna S., Dall, Morten, Treebak, Jonas T., Gillum, Matthew P., Torekov, Signe S., Windeløv, Johanne A., Hunt, Jenna E., Kjeldsen, Sasha A.S., Jepsen, Sara L., Vasilopoulou, Catherine G., Knop, Filip K., Ørskov, Cathrine, Werge, Mikkel P., Bisgaard, Hanne Cathrine, Eriksen, Peter Lykke, Vilstrup, Hendrik, Gluud, Lise Lotte, Holst, Jens J., Wewer Albrechtsen, Nicolai J.

Publikováno v: In Molecular Metabolism December 2020 42

Novel agonist- and antagonist-based radioligands for the GLP-2 receptor - useful tools for studies of basic GLP-2R pharmacology

Autor: Gadgaard, Sarina, van der Velden, Wijnand J C, Schiellerup, Sine P, Hunt, Jenna Elizabeth, Gabe, Maria B N, Windeløv, Johanne Agerlin, Boer, Geke Aline, Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens J., Hartmann, Bolette, Rosenkilde, Mette M

Publikováno v: Gadgaard, S, van der Velden, W J C, Schiellerup, S P, Hunt, J E, Gabe, M B N, Windeløv, J A, Boer, G A, Kissow, H, Ørskov, C, Holst, J J, Hartmann, B & Rosenkilde, M M 2022, ' Novel agonist-and antagonist-based radioligands for the GLP-2 receptor-useful tools for studies of basic GLP-2R pharmacology ', British Journal of Pharmacology, vol. 179, no. 9, pp. 1998-2015 . https://doi.org/10.1111/bph.15766

BACKGROUND: Glucagon-like peptide-2(GLP-2) is a pro-glucagon-derived hormone secreted from intestinal enteroendocrine L-cells with actions on gut and bones. GLP-2(1-33) is cleaved by the enzyme DPP-4, forming GLP-2(3-33) which has low intrinsic activ

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