Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Win Pin Ng"'
Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression.
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 4, p e1002467 (2012)
Cytokinesis occurs through the coordinated action of several biochemically-mediated stresses acting on the cytoskeleton. Here, we develop a computational model of cellular mechanics, and using a large number of experimentally measured biophysical par
Externí odkaz:
https://doaj.org/article/beaf9d464cb84f4594a921fe8c12f09b
Autor:
Stephanie Pei Li Saw, Win Pin Ng, Siqin Zhou, Gillianne Lai, Aaron Tan, Mei-Kim Ang, Wan-Teck Lim, Ravindran Kanesvaran, Quan Sing Ng, Amit Jain, Wan Ling Tan, Tanujaa Rajasekaran, Johan Chan, Yi Lin Teh, Mengyuan Pang, Jia Chi Yeo, Angela Takano, Boon-Hean Ong, Eng Huat Tan, Sze Huey Tan, Anders Skanderup, Daniel S. W. Tan
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4055b1e34e6a9bf1ed134de3e3f3d35b
https://doi.org/10.2139/ssrn.4127727
https://doi.org/10.2139/ssrn.4127727
Autor:
Kevin D. Webster, Caroline Stefani, Patricia Bassereau, Win Pin Ng, Daniel A. Fletcher, Emmanuel Lemichez, Eva M. Schmid
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, 2017, 28 (20), pp.2650-2660. ⟨10.1091/mbc.E17-01-0080⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (20), pp.2650-2660. ⟨10.1091/mbc.E17-01-0080⟩
Molecular Biology of the Cell, 2017, 28 (20), pp.2650-2660. ⟨10.1091/mbc.E17-01-0080⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (20), pp.2650-2660. ⟨10.1091/mbc.E17-01-0080⟩
Transcellular tunnels in endothelial cells can be formed by leukocytes and pathogens as a way of crossing the endothelial barrier. Using force microscopy and fluorescence microscopy, we find that the actin cytoskeleton provides the primary mechanical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698f47e642c0655a39f52ea46c13e203
https://doi.org/10.1091/mbc.e17-01-0080
https://doi.org/10.1091/mbc.e17-01-0080
Autor:
Yee Seir Kee, Ji Hoon Kim, Elizabeth H. Chen, Win Pin Ng, Douglas N. Robinson, Shuo Li, Yixin Ren, Guofeng Zhang, Daniel A. Fletcher, Sungmin Son, Shiliang Zhang
Publikováno v:
Developmental Cell. 32(5):561-573
SummaryMembrane fusion is an energy-consuming process that requires tight juxtaposition of two lipid bilayers. Little is known about how cells overcome energy barriers to bring their membranes together for fusion. Previously, we have shown that cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a4ca5b97932eede5c0178699a57aeb
Publikováno v:
Biophysical journal, vol 107, iss 1
Adherent cells generate forces through acto-myosin contraction to move, change shape, and sense the mechanical properties of their environment. They are thought to maintain defined levels of tension with their surroundings despite mechanical perturba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3b5d7cb07eb46ae33eae87b1c5411e
Deconvolution of the Cellular Force-Generating Subsystems that Govern Cytokinesis Furrow Ingression.
Autor:
Poirier, Christopher C.1, Win Pin Ng2,3, Robinson, Douglas N.2,4,5, Iglesias, Pablo A.1,3 pi@jhu.edu
Publikováno v:
PLoS Computational Biology. Apr2012, Vol. 8 Issue 4, p1-12. 12p.
Publikováno v:
Cell Cycle. 6:1886-1895
Mitotic spindle assembly and chromosome segregation are controlled by the cell cycle machinery and by the guanosine triphosphatase Ran (RanGTPase). We developed a spatial model that allowed us to simulate RanGTP production with different degrees of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7e149fefb7338f619a24540804ada4
https://doi.org/10.4161/cc.6.15.4487
https://doi.org/10.4161/cc.6.15.4487
Autor:
Caren L. Freel Meyers, Ronald S. Rock, David J. Meyers, Hoku West-Foyle, Qingfeng Zhu, Agata K. Krenc, Lindsay B. Avery, Robert A. Anders, Douglas N. Robinson, Yixin Ren, Win Pin Ng, Alexandra Surcel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(5)
Current approaches to cancer treatment focus on targeting signal transduction pathways. Here, we develop an alternative system for targeting cell mechanics for the discovery of novel therapeutics. We designed a live-cell, high-throughput chemical scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf288cbf4e8c9a09eae30574238b39b
https://pubmed.ncbi.nlm.nih.gov/25605895
https://pubmed.ncbi.nlm.nih.gov/25605895
Publikováno v:
Journal of the Royal Society, Interface. 9(71)
The ability of cells to adapt their mechanical properties to those of the surrounding microenvironment (tensional homeostasis) has been implicated in the progression of a variety of solid tumours, including the brain tumour glioblastoma multiforme (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a987b7965539ef5328687b7c918c44
https://pubmed.ncbi.nlm.nih.gov/22158841
https://pubmed.ncbi.nlm.nih.gov/22158841
Publikováno v:
Biophysical Journal. 100(3)
Cytokinesis is one of the most elegant transformations in nature, whereby a mother cell is separated into two identical daughter cells. This complex process relies not only on biochemical reactions, but also on the mechanics and geometry. We create a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5deab8de9d3a44740b58062784e5db45