Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Wim Schepens"'
Publikováno v:
Catalysts, Vol 7, Iss 3, p 74 (2017)
The (site-selective) derivatization of amino acids and peptides represents an attractive field with potential applications in the establishment of structure–activity relationships and labeling of bioactive compounds. In this respect, bioorthogonal
Externí odkaz:
https://doaj.org/article/4cc31b5861f443a0a5b8af8bf14a532b
Autor:
and Annemieke Verstuyf, Roger Bouillon, Maurits Vandewalle, Dirk Van Haver, Wim Schepens, Pierre J. De Clercq
Publikováno v:
Organic Letters. 8:4247-4250
A novel series of analogues of calcitriol (1) is developed featuring a spirocyclic central core resulting from C18/C21-connection and C15/C16-deletion (2a, 2b). The synthesis of the key intermediate involves an Eschenmoser rearrangement of an enantio
Autor:
Tom Willemse, Wim Schepens, Rebecca J. M. Goss, Steven Ballet, Duncan R. M. Smith, Danai S. Gkotsi, Bert U. W. Maes
Publikováno v:
ChemInform. 45
A bacterial cell lysate containing tryptophan synthase is developed to enable a scalable one-pot biotransformation of indoles to the corresponding tryptophans with serine as coupling partner.
Autor:
Kristof Van Emelen, Stina Lundgren, Lieven Baert, Jörg K. Wegner, Klara Rombauts, Wim Gaston Verschueren, Daniel Jönsson, Nigel Austin, Åsa Rosenquist, Kevin E. B. Parkes, Jan Willem Thuring, Patrick Sterkens, Wim Van De Vreken, Chantal Masungi, Inge Dierynck, Bart Kesteleyn, Hans Wallberg, Geerwin Hache, Katie Amssoms, Bertil Samuelsson, Bart Stoops, Wim Schepens, Genadiy Kalayanov, Greet Meurs
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(1)
The design and synthesis of novel HIV-1 protease inhibitors (PIs) (1-22), which display high potency against HIV-1 wild-type and multi-PI-resistant HIV-mutant clinical isolates, is described. Lead optimization was initiated from compound 1, a Phe-Phe
Autor:
Roger Bouillon, Freek Vrielynck, Annemieke Verstuyf, Wim Schepens, Garrett Berlond Minne, Pierre J. De Clercq, Maurits Vandewalle, Dirk Van Haver, Frederik De Buysser
Publikováno v:
ChemInform. 39
Autor:
Annemieke Verstuyf, Dirk Van Haver, Maurits Vandewalle, Garrett Berlond Minne, Frederik De Buysser, Freek Vrielynck, Roger Bouillon, Pierre J. De Clercq, Wim Schepens
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 103(3-5)
During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural modifications in the central CD-ring system. Modifications have first involved the introduction of
Autor:
Wim Schepens, Roger Bouillon, Annemieke Verstuyf, Dirk Van Haver, Pierre J. De Clercq, Maurits Vanderwalle
Publikováno v:
ChemInform. 35
The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1alpha,25-dihydroxyvitamin D(3), lacking the D-ring and featuring a connection between C-18 and C-21 (spiro[5.5]undecane CF-ring analogues), is described. The central
Autor:
Roger Bouillon, Maurits Vandewalle, Dirk Van Haver, Pierre J. De Clercq, Wim Schepens, Annemieke Verstuyf
Publikováno v:
ChemInform. 35
The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1α,25-dihydroxyvitamin D3, lacking the D-ring and featuring a connection between C-12 and C-21 (cis-perhydrindane CE-ring analogues), is described. The synthesis of