Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Wim Martinet"'
Autor:
Cédric H. G. Neutel, Callan D. Wesley, Cindy van Loo, Céline Civati, Freke Mertens, Michelle Zurek, Anja Verhulst, Isabel Pintelon, Winnok H. De Vos, Bart Spronck, Lynn Roth, Guido R. Y. De Meyer, Wim Martinet, Pieter-Jan Guns
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Calciprotein particles (CPPs) are an endogenous buffering system, clearing excessive amounts of Ca2+ and PO4 3- from the circulation and thereby preventing ectopic mineralization. CPPs circulate as primary CPPs (CPP1), which are small spheri
Externí odkaz:
https://doaj.org/article/ec219c4be4484da5ac08fecee8cd9237
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Arterial stiffness, a key indicator of vascular health, encompassing active (vascular tone) and passive (extracellular matrix) components. This study aims to address how these different components affect arterial stiffness along the aorta an
Externí odkaz:
https://doaj.org/article/8d61bd1c723b4cf8931c209ee6c633a5
Publikováno v:
Vascular Biology, Vol 6, Iss 1, Pp 1-9 (2024)
The impact of α-tocopherol on atherosclerosis is unclear and controversial. While some studies suggest potential benefits, such as antioxidant properties that may reduce oxidative stress, other studies indicate no significant preventive effects. The
Externí odkaz:
https://doaj.org/article/ce53fc49407642d2823076ec8da3428d
Publikováno v:
Vascular Biology, Vol 6, Iss 1, Pp 1-9 (2024)
Ferroptosis is a type of regulated necrosis that is associated with iron-dependent accumulation of lipid hydroperoxides. Given that iron deposition and lipid peroxidation initiate ferroptosis in atherosclerosis and contribute to further plaque develo
Externí odkaz:
https://doaj.org/article/2e0c95ac1b1a4623bf9253d0e0f6570b
Autor:
Callan D. Wesley, Annarita Sansonetti, Cedric H. G. Neutel, Dustin N. Krüger, Guido R. Y. De Meyer, Wim Martinet, Pieter-Jan Guns
Publikováno v:
Biology, Vol 13, Iss 10, p 844 (2024)
Proteasome inhibitors such as bortezomib and carfilzomib induce apoptosis and are a cornerstone in the treatment of relapsed or refractory multiple myeloma. However, concerns have emerged concerning their link to cancer therapy-related cardiovascular
Externí odkaz:
https://doaj.org/article/47630c895e1d4d558ebbda20a048bc49
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2024)
BackgroundThe discovery of novel biomarkers that improve current cardiovascular risk prediction models of acute coronary syndrome (ACS) is needed for the identification of very high-risk patients and therapeutic decision-making. Autophagy is a highly
Externí odkaz:
https://doaj.org/article/bb1b7be8c9c64cd0946f2f805eebd4cd
Autor:
Murat Bozdag, Freke Mertens, An Matheeussen, Natascha Van Pelt, Kenn Foubert, Nina Hermans, Guido R. Y. De Meyer, Koen Augustyns, Wim Martinet, Guy Caljon, Pieter Van der Veken
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4693 (2024)
Herein, we report a series of 1,3-diarylpyrazoles that are analogues of compound 26/HIT 8. We previously identified this molecule as a ‘hit’ during a high-throughput screening campaign for autophagy inducers. A variety of synthetic strategies wer
Externí odkaz:
https://doaj.org/article/18dabefed2da4cbd90ffbaf508400672
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Due to its viscoelastic properties, the aorta aids in dampening blood pressure pulsatility. At the level of resistance-arteries, the pulsatile flow will be transformed into a continuous flow to allow for optimal perfusion of end organs such as the ki
Externí odkaz:
https://doaj.org/article/683eb2058dc74387803314d873822cd9
Autor:
Sofie De Moudt, Jhana O. Hendrickx, Cédric Neutel, Dorien De Munck, Arthur Leloup, Guido R. Y. De Meyer, Wim Martinet, Paul Fransen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A 24-month aging study in male C57Bl/6 mice reveals that aortic aging precedes cardiovascular disease and is due to changes in the extracellular matrix and vascular smooth muscle cell signaling.
Externí odkaz:
https://doaj.org/article/a2bb32bb6972419eaf34a34dc3f2ae01
Publikováno v:
Physiological Reports, Vol 10, Iss 18, Pp n/a-n/a (2022)
Abstract In vivo angiotensin II (AngII)‐treatment is a widely used experimental model to induce cardiovascular disease and results in a high likelihood of abdominal aorta aneurysm (AAA) formation. This involves progressive and irreversible focal di
Externí odkaz:
https://doaj.org/article/e1c8f1cf7259472f85ca8f94b760f9dd