Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Wim Mandemakers"'
Autor:
Martyna M. Grochowska, Federico Ferraro, Ana Carreras Mascaro, Domenico Natale, Amber Winkelaar, Valerie Boumeester, Guido J. Breedveld, Vincenzo Bonifati, Wim Mandemakers
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/e390fc4c883e438a9d69c40e5ea15425
Publikováno v:
Bio-Protocol, Vol 12, Iss 19 (2022)
Loss-of-function (LoF) variants in the low-density lipoprotein receptor–related protein 10 gene (LRP10) have been recently implicated in the development of neurodegenerative diseases, including Parkinson's disease (PD), PD dementia (PDD), and demen
Externí odkaz:
https://doaj.org/article/c10b0669b4074027b5a06b7fd5f7f364
Autor:
Pauline Mencke, Ibrahim Boussaad, Gizem Önal, Anneke J.A. Kievit, Agnita J.W. Boon, Wim Mandemakers, Vincenzo Bonifati, Rejko Krüger
Publikováno v:
Stem Cell Research, Vol 62, Iss , Pp 102792- (2022)
Here, we describe an induced pluripotent stem cell (iPSC) line that was derived from fibroblasts obtained from a monogenic Parkinson’s disease (PD) patient. The disease was caused by a c.634-636delGCC mutation in the PARK7 gene leading to p.158P de
Externí odkaz:
https://doaj.org/article/32ec1b380b3340ee805589773bb5f5b3
Autor:
Pauline Mencke, Zoé Hanss, Javier Jarazo, François Massart, Arkadiusz Rybicki, Elizabet Petkovski, Enrico Glaab, Ibrahim Boussaad, Vincenzo Bonifati, Jens Christian Schwamborn, Wim Mandemakers, Rejko Krüger
Publikováno v:
Stem Cell Research, Vol 62, Iss , Pp 102815- (2022)
We describe the generation of an isogenic control cell line DJ-1-delP GC13 from an induced pluripotent stem cell (iPSC) line DJ-1-delP LCSBi008-A that was derived from fibroblasts obtained from a Parkinson’s disease (PD) patient. Using CRISPR/Cas9
Externí odkaz:
https://doaj.org/article/98b9fec390b8422c9118d59c5484a789
Autor:
Federico Ferraro, Christina Fevga, Vincenzo Bonifati, Wim Mandemakers, Ahmed Mahfouz, Marcel Reinders
Publikováno v:
Cells, Vol 11, Iss 2, p 198 (2022)
Several studies have analyzed gene expression profiles in the substantia nigra to better understand the pathological mechanisms causing Parkinson’s disease (PD). However, the concordance between the identified gene signatures in these individual st
Externí odkaz:
https://doaj.org/article/ba957dfd946040e194d977833146ea9e
Autor:
Aikaterini S. Papadopoulou, Lutgarde Serneels, Tilmann Achsel, Wim Mandemakers, Zsuzsanna Callaerts-Vegh, James Dooley, Pierre Lau, Torik Ayoubi, Enrico Radaelli, Marco Spinazzi, Melanie Neumann, Sébastien S. Hébert, Asli Silahtaroglu, Adrian Liston, Rudi D'Hooge, Markus Glatzel, Bart De Strooper
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 275-288 (2015)
miR-29 is expressed strongly in the brain and alterations in expression have been linked to several neurological disorders. To further explore the function of this miRNA in the brain, we generated miR-29a/b-1 knockout animals. Knockout mice develop a
Externí odkaz:
https://doaj.org/article/4cfe1d691b9748729b660c08f5ce439c
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 582-593 (2012)
In spite of a clear genetic link between Parkinson's disease (PD) and mutations in LRRK2, cellular localization and physiological function of LRRK2 remain debated. Here we demonstrate the immunohistochemical localization of LRRK2 in adult mouse and e
Externí odkaz:
https://doaj.org/article/0d6aec80c7ed4e308418159a88b5043c
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 2, Pp 285-290 (2012)
Alzheimer's disease (AD) is a complex neurodegenerative disorder and is the most common form of dementia in the elderly. Accumulating evidence in AD research suggests that alterations in the microRNA (miRNA) network could contribute to risk for the d
Externí odkaz:
https://doaj.org/article/17efd9f9952d4a1180456056c3582928
Autor:
Véronique Dorval, Wim Mandemakers, Francis Jolivette, Laetitia Coudert, Rachid Mazroui, Bart De Strooper, Sébastien S Hébert
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85510 (2014)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of genetic Parkinson's disease (PD). The biological function of LRRK2 and how mutations lead to disease remain poorly defined. It has been proposed that LRRK2 could functio
Externí odkaz:
https://doaj.org/article/e58ecffaf8174c4486532ec434b85745
Autor:
Ana Carreras Mascaro, Martyna M. Grochowska, Valerie Boumeester, Natasja F. J. Dits, Ece Naz Bilgiҫ, Guido J. Breedveld, Leonie Vergouw, Frank Jan de Jong, Martin E. van Royen, Vincenzo Bonifati, Wim Mandemakers
Autosomal dominant variants inLRP10have been identified in patients with Lewy body diseases (LBDs), including Parkinson’s disease (PD), Parkinson’s disease-dementia (PDD), and dementia with Lewy bodies (DLB). Nevertheless, there is little mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b4b6b6a8f57db63c217e1b584135c9
https://doi.org/10.1101/2023.05.12.540510
https://doi.org/10.1101/2023.05.12.540510
