Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells.

Autor: Karel H van der Pol, Jan Koenderink, Jeroen J M W van den Heuvel, Petra van den Broek, Janny Peters, Imke D W van Bunningen, Jeanne Pertijs, Frans G M Russel, Jim Koldenhof, Wim J Morshuis, Joris van Drongelen, Tom J J Schirris, Andries van der Meer, Gerard A Rongen

Publikováno v: PLoS ONE, Vol 19, Iss 6, p e0305906 (2024)

Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis. Febuxostat inhibits BCRP- and allopurinol stimulates MRP4-mediated uric acid efflux in

Externí odkaz: https://doaj.org/article/fd27e0ee1021449984bd8991649ed5a0

Statins and Cardiomyocyte Metabolism, Friend or Foe?

Autor: Tim Somers, Sailay Siddiqi, Wim J. Morshuis, Frans G. M. Russel, Tom J. J. Schirris

Publikováno v: Journal of Cardiovascular Development and Disease, Vol 10, Iss 10, p 417 (2023)

Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and are the cornerstone of lipid-lowering treatment. They significantly reduce cardiovascular morbidity and mortality. However, musculoskeletal symptoms are observe

Externí odkaz: https://doaj.org/article/0369d11886e34b0fbea49a9a76ae6a9e

Perigraft hygroma mimicking recurrent angiosarcoma of the right atrium

Autor: Jort Evers, Kinsing Ko, Guillaume S.C. Geuzebroek, Wim J. Morshuis, Tim Smith

Publikováno v: General Thoracic and Cardiovascular Surgery, 70, 2, pp. 184-189
General Thoracic and Cardiovascular Surgery, 70, 184-189

Contains fulltext : 251631.pdf (Publisher’s version ) (Closed access) Primary cardiac angiosarcoma is extremely rare, has a poor prognosis and has no specific clinical manifestation. A 31-year-old pregnant woman presented to the emergency departmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05191ad3647e0c8eae1ea391b2d7d5c0
https://doi.org/10.1007/s11748-021-01737-8

Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study

Autor: Jelle Gerretsen, Denise Waanders, Johannes G. van der Hoeven, Remi Beunders, Leonie S. E. Buijsse, Matthijs Kox, Emma J. Kooistra, Pleun Hemelaar, Lucas T. van Eijk, Roger van Groenendael, Jan Hofland, Maud G. A. Lamberts, Wim J. Morshuis, Wout J. Claassen, Gert Wensvoort, Peter Pickkers

Publikováno v: van Groenendael, R, Beunders, R, Hemelaar, P, Hofland, J, Morshuis, W J, van der Hoeven, J G, Gerretsen, J, Wensvoort, G, Kooistra, E J, Claassen, W J, Waanders, D, Lamberts, M G A, Buijsse, L S E, Kox, M, van Eijk, L T & Pickkers, P 2021, ' Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study ', Critical Care Medicine, pp. 790-803 . https://doi.org/10.1097/CCM.0000000000004847
Critical Care Medicine
Critical Care Medicine, 790-803. Lippincott Williams and Wilkins
STARTPAGE=790;ENDPAGE=803;ISSN=0090-3493;TITLE=Critical Care Medicine
Critical Care Medicine, 49, 790-803
Critical Care Medicine, 49, 5, pp. 790-803

Supplemental Digital Content is available in the text.
OBJECTIVES: To determine the safety and efficacy of human chorionic gonadotropin hormone-derivative EA-230 in cardiac surgery patients. Cardiac surgery induces systemic inflammation and may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9af3097db36351721afd314214afd6e
https://hdl.handle.net/2066/232791

Proof of principle of a novel co-pulsating intra-ventricular membrane pump

Autor: Dirk J. Duncker, Frank Gommans, Jos Thannhauser, Daniël I. M. van Dort, Harry Suryapranata, Guillaume S.C. Geuzebroek, Tim ten Cate, Wim J. Morshuis

Publikováno v: Artificial Organs, 44(12), 1267-1275. Wiley-Blackwell Publishing Ltd
Artificial Organs, 44, 1267-1275
Artificial Organs, 44, 12, pp. 1267-1275

Contains fulltext : 229199.pdf (Publisher’s version ) (Closed access) In this proof of principle study, we investigated the effectiveness and safety of hemodynamic support with the Intra-Ventricular Membrane Pump (IVMP). The IVMP was implanted into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d911d1565b6e7196b084f15cfb1567b0
https://doi.org/10.1111/aor.13757