Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Wim G. J. Hol"'
Autor:
Chelsea S. Rule, Young-Jun Park, Jaclyn R. Delarosa, Stewart Turley, Wim G. J. Hol, Sarah McColm, Colby Gura, Frank DiMaio, Konstantin V. Korotkov, Maria Sandkvist
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
ABSTRACT The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including Vibrio cholerae. Disruption of the T2SS genes in V. cholerae results in loss of s
Externí odkaz:
https://doaj.org/article/d20dbb7d0226484bb0f34d676bff932b
Autor:
Kayode K Ojo, Molly C Reid, Latha Kallur Siddaramaiah, Joachim Müller, Pablo Winzer, Zhongsheng Zhang, Katelyn R Keyloun, Rama Subba Rao Vidadala, Ethan A Merritt, Wim G J Hol, Dustin J Maly, Erkang Fan, Wesley C Van Voorhis, Andrew Hemphill
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92929 (2014)
Despite the enormous economic importance of Neospora caninum related veterinary diseases, the number of effective therapeutic agents is relatively small. Development of new therapeutic strategies to combat the economic impact of neosporosis remains a
Externí odkaz:
https://doaj.org/article/d64eee0005e046cc9e4cbb234e0d589e
Autor:
Chelsea S. Rule, Frank DiMaio, Stewart Turley, Wim G. J. Hol, Maria Sandkvist, Konstantin V. Korotkov, Colby Gura, Sarah McColm, Young-Jun Park, Jaclyn Delarosa
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
mSphere
mSphere
Genome-wide transposon mutagenesis has identified the genes encoding the T2SS in Vibrio cholerae as essential for viability, but the reason for this is unclear. Mutants with deletions or insertions in these genes can be isolated, suggesting that they
Autor:
F. Scott Mathews, Wim G. J. Hol
Publikováno v:
Principles and Applications of Quinoproteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f5310e4e3d4577f7a63b9ad53b3929
https://doi.org/10.1201/9781003067009-10
https://doi.org/10.1201/9781003067009-10
Autor:
Christophe L. M. J. Verlinde, Aisha Mushtaq, Sayaka Shibata, Omeed Faghih, Erkang Fan, Frederick S. Buckner, Wim G. J. Hol, Zhongsheng Zhang, Ranae M. Ranade, J. Robert Gillespie, Ximena Barros-Álvarez, Nora Molasky, Robert K. M. Choy, Eugenio L. de Hostos, Wenlin Huang
Publikováno v:
RSC Med Chem
Based on crystal structures of Trypanosoma brucei methionyl-tRNA synthetase (TbMetRS) bound to inhibitors, we designed, synthesized, and evaluated two series of novel TbMetRS inhibitors targeting this parasite enzyme. One series has a 1,3-dihydro-imi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40802292719ab4d3fb67a2ecdac0de38
https://europepmc.org/articles/PMC7649832/
https://europepmc.org/articles/PMC7649832/
Autor:
Samuel L.M. Arnold, Erkang Fan, Wim G. J. Hol, Frederick S. Buckner, Christophe L. M. J. Verlinde, Matthew A. Hulverson, J. Robert Gillespie, Zhongsheng Zhang, Yuichiro Akao, Christopher D. Huston, Wesley C. Van Voorhis, Wenlin Huang, Rajiv S. Jumani, Robert K. M. Choy, Sayaka Shibata, Ryan Choi, Ranae M. Ranade, Atsuko Ochida
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Cryptosporidiosis is one of the leading causes of moderate to severe diarrhea in children in low-resource settings. The therapeutic options for cryptosporidiosis are limited to one drug, nitazoxanide, which unfortunately has poor activity in the most
Autor:
Ranae M. Ranade, Zhongsheng Zhang, Michael H. Gelb, Cho Yeow Koh, Wenlin Huang, Sayaka Shibata, Christophe L. M. J. Verlinde, Frederick S. Buckner, J. Robert Gillespie, Nagendar Pendem, Matthew A. Hulverson, Wim G. J. Hol, Jasmine Nguyen, Erkang Fan
Publikováno v:
ACS Infectious Diseases
Fluorination is a well-known strategy for improving the bioavailability of drug molecules. However, its impact on efficacy is not easily predicted. On the basis of inhibitor-bound protein crystal structures, we found a beneficial fluorination spot fo
Autor:
Ximena Barros-Álvarez, Wim G. J. Hol, Christophe L. M. J. Verlinde, Stewart Turley, Frederick S. Buckner, Erkang Fan, Ranae M. Ranade, Nicole A. Duster, J. Robert Gillespie
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 74(Pt 4)
Mycobacterium tuberculosisis a pathogenic bacterial infectious agent that is responsible for approximately 1.5 million human deaths annually. Current treatment requires the long-term administration of multiple medicines with substantial side effects.
Publikováno v:
Chemistry and Biochemistry of Flavoenzymes ISBN: 9781351070584
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::544e95f8c4a6f572b540283a453f98d3
https://doi.org/10.1201/9781351070584-2
https://doi.org/10.1201/9781351070584-2