Výsledky vyhledávání - "Wim F.P.M. Van den Hof"

Integrative '-Omics' Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis

Autor: Simone G. J. van Breda, Jarno E J Wolters, Theo M. de Kok, Daniel H. J. Theunissen, Jos C. S. Kleinjans, Marcel H. M. van Herwijnen, Wim F.P.M. Van den Hof, Danyel Jennen, Frank G. Schaap

Publikováno v: Chemical Research in Toxicology, 29(12), 2164-2174. American Chemical Society

Cyclosporine A (CsA) is an undecapeptide with strong immunosuppressant activities and is used a lot after organ transplantation. Furthermore, it may induce cholestasis in the liver. In general, the drug-induced cholestasis (DIC) pathway includes gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5d8dcf1053c0b22ea933df8b03e6e8
https://doi.org/10.1021/acs.chemrestox.6b00337

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Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

Autor: Will K. W. H. Wodzig, Wim F.P.M. Van den Hof, Anke Van Summeren, Ainhoa Ruiz-Aracama, Joost H.M. van Delft, Danyel Jennen, Maarten L. J. Coonen, Stan Gaj, Jos C. S. Kleinjans, Karen Brauers

Publikováno v: Toxicology in Vitro, 29(3), 489-501. Elsevier Science
Toxicology in Vitro, 29(3), 489-501
Toxicology in Vitro 29 (2015) 3

In order to improve attrition rates of candidate-drugs there is a need for a better understanding of the mechanisms underlying drug-induced hepatotoxicity. We aim to further unravel the toxicological response of hepatocytes to a prototypical cholesta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47159ba0a81181065fe60a97e5cea4d6
https://doi.org/10.1016/j.tiv.2014.12.016

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Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity

Autor: Anke Van Summeren, Will K. W. H. Wodzig, Karen Brauers, Arjen Lommen, Maarten L. J. Coonen, Wim F.P.M. Van den Hof, Jos C. S. Kleinjans, Marcel H. M. van Herwijnen

Publikováno v: Toxicology 324 (2014)
Toxicology, 324, 18-26
Toxicology, 324, 18-26. Elsevier Ireland Ltd

The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better pre-clinical toxicity tests are needed. In order to bypass animal models for toxicity screening, we e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf04d72be065cbfc26f3213681a2c00
https://pubmed.ncbi.nlm.nih.gov/25047351

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