Výsledky vyhledávání - "Wim De Buysser"

Synthesis and 2,7-functionalization of the bicyclic lactam 2-benzyloctahydropyrido[1,2-a]pyrazin-6-one

Autor: Stefan Van den Branden, Frans Compernolle, Wim De Buysser, Georges J. Hoornaert, M. Ashty Saleh

Publikováno v: The Journal of Organic Chemistry. 58:690-695

This report describes the synthesis of the title compound 7 and its conversion into 2,7-substituted octahydro-2H-pyrido[1,2-a]pyrazines, i.e., bicyclic analogues of the monocyclic piperazine drug lidoflazine. The synthesis of 7 is based on a 3-fold a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e76144ff5aa7af3a5ded75e41f03154
https://doi.org/10.1021/jo00055a023

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An entry into the novel tetracyclic system 6H-pyrido[1′,2′:4,5]pyrazino[1,2-a]benzimidazole. Synthesis and conformational study of the 1,2,3,4,13,13a-hexahydro-3,3-ethylenedioxy and 3-ketone derivatives

Autor: Wim De Buysser, Suzanne Toppet, Georges J. Hoornaert, M. Ashty Saleh, Frans Compernolle

Publikováno v: Journal of Heterocyclic Chemistry. 28:1965-1969

The synthesis of the tetracyclic title compounds, acetal 5 and ketone 6, is presented. The key step, formation of the imidazole ring to give compound 5, involved the acid catalysed dehydration of the 2-(o-aminophenyl)lactam 7b. This was generated fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07068fc77d99bb011dc52931bbabf67f
https://doi.org/10.1002/jhet.5570280829

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