Výsledky vyhledávání - "Wim Albert Alex Aelterman"

Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 3. Development of an Acid-Catalyzed Racemization Process for (S)-2,8-(Dimethoxy)-5-{4-[2-(1-piperidinyl)ethoxy]phenyl}−11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene

Autor: Dominique Depré, Wim Albert Alex Aelterman, Zhihua Sui, Xun Li, Dominic Ormerod, Andras Horvath, Nareshkumar F. Jain, Ronald K. Russell

Publikováno v: Organic Process Research & Development. 13:102-105

A novel and economical process was developed for recycling the undesired enantiomer, (S)-2,8-dimethoxy-5-{4-[2-(1-piperidinyl)ethoxy]phenyl}-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene (1b) obtained from chiral chromatographic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8f8e82beeee259d1ad9404fc112ffaf
https://doi.org/10.1021/op800237y

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Development of a Concise Scaleable Synthesis of 2-Chloro-5-(pyridin-2-yl) Pyrimidine via a Negishi Cross-Coupling

Autor: Wim Albert Alex Aelterman, Dominic Ormerod, Albert Willemsens, Carlos Perez-Balado, Narda Mertens

Publikováno v: Organic Process Research & Development. 11:237-240

A practical and scaleable synthesis of 2-chloro-5-(pyridin-2-yl) pyrimidine, an intermediate in the synthesis of a selective PDE-V inhibitor, was developed. A Negishi cross-coupling between the in situ prepared 2-pyridylzinc chloride and 5-iodo-2-chl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d014898583a6c8ff0e850f2a759b7b60
https://doi.org/10.1021/op060241c

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Development of a Scalable and Safe Procedure for the Production of (3R)-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]- quinolin-9-one, an Intermediate in the Synthesis of PDE-V Inhibitors RWJ387273 (R301249) and RWJ444772 (R290629)

Autor: István E. Markó, Dominique Ormerod, Sébastien Lemaire, Wim Albert Alex Aelterman, Ivan Vervest, Christine Fannes, Narda Mertens, Bert Willemsens

Publikováno v: Organic Process Research & Development. 10:1275-1281

A scalable and safe process for the oxidative rearrangement of beta-carboline to quinolone derivatives, intermediates in the synthesis of PDE-V inhibitors RWJ387273 (R301249) and RWJ444772 (R290629), has been developed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4301e5bd6254f68a0e94dd00fbc55cb7
https://doi.org/10.1021/op060099f

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Conversion of the Laboratory Synthetic Route of the N-Aryl-2-benzothiazolamine R116010 to a Manufacturing Method

Autor: Ivan Vervest, Yolande Lang, Fons De Knaep, Bert Willemsens, Wim Albert Alex Aelterman, and Stef Leurs

Publikováno v: Organic Process Research & Development. 5:467-471

A facile and large-scale preparation of the antitumor agent R116010 has been developed. The new synthetic process requires four steps: (i) Friedel−Crafts reaction of N-phenyl-2-benzothiazolamine with 2-chloropropionyl chloride, (ii) conversion of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d070b216ea956ef1b109ede9a14ced40
https://doi.org/10.1021/op0100201

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ChemInform Abstract: Conversion of the Laboratory Synthetic Route of the N-Aryl-2-benzothiazolamine R116010 to a Manufacturing Method

Autor: Fons De Knaep, Yolande Lang, Wim Albert Alex Aelterman, Ivan Vervest, Bert Willemsens, Stef Leurs

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::683b21ea6cde58c823f5de8ccd8b8fc2
https://doi.org/10.1002/chin.200207122

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