Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Wim Aelterman"'
Autor:
Frank Roschangar, Jun Li, Yanyan Zhou, Wim Aelterman, Alina Borovika, Juan Colberg, David P. Dickson, Fabrice Gallou, John D. Hayler, Stefan G. Koenig, Michael E. Kopach, Birgit Kosjek, David K. Leahy, Erin O’Brien, Austin G. Smith, Manuel Henry, Jutta Cook, Roger A. Sheldon
Publikováno v:
ACS Sustainable Chemistry and Engineering, 10(16)
The large and steadily growing demand for medicines combined with their inherent resource-intensive manufacturing necessitates a relentless push for their sustainable production. Pharmaceutical companies are constantly seeking to perform reliable lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77447aad8953a5d71e8bac64965dd6a1
https://doi.org/10.1021/acssuschemeng.1c01940
https://doi.org/10.1021/acssuschemeng.1c01940
Publikováno v:
Synlett. 28:207-213
A variety of different N-[2-chloro-4-(chloromethyl)pent-4-enylidene]amines and N-(2,6-dichlorohex-4-enylidene)amines was prepared for the first time, and their reactivity as eligible building blocks for the synthesis of biologically relevant nitrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f193323af5f2f57ad71162997a41b09
https://doi.org/10.1055/s-0036-1588882
https://doi.org/10.1055/s-0036-1588882
Autor:
Geert Van der Vorst, Sam Debaveye, Philippe Cappuyns, Wim Aelterman, Jo Dewulf, Steven De Meester, Bert Heirman, Wouter De Soete
Publikováno v:
Environmental Science & Technology. 48:12247-12255
The pharmaceutical and fine chemical industries are eager to strive toward innovative products and technologies. This study first derives hotspots in resource consumption of 2839 Basic Operations in 40 Active Pharmaceutical Ingredient synthesis steps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8155c544d31634ece459cd80994af7
https://doi.org/10.1021/es502562d
https://doi.org/10.1021/es502562d
Publikováno v:
Tetrahedron Letters. 45:441-444
Treatment of α-chloro-δ-(trimethylsilyloxy)ketimines, obtained by regiospecific alkylation of α-chloroketimines with 3-bromo-1-(trimethylsilyloxy)propane, with bases and nucleophiles leads to a variety of oxygen-containing heterocycles, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55104f9168ffe79273f194b0b4f69fc0
https://doi.org/10.1016/j.tetlet.2003.09.232
https://doi.org/10.1016/j.tetlet.2003.09.232
Publikováno v:
Pure and Applied Chemistry. 75:1433-1442
The synthetic potential of lithio 3-halo-1-azaallylic anions as building blocks in organic chemistry and especially in heterocyclic chemistry will be highlighted by the synthesis of functionalized imines, obtained after reaction of 3-halo-1-azaallyli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb421280745db7ac5922f5c7a73d5e0
https://doi.org/10.1351/pac200375101433
https://doi.org/10.1351/pac200375101433
Publikováno v:
The Journal of Organic Chemistry. 66:53-58
A new synthesis of 2,3-disubstituted pyrroles and pyridines is described. The reaction of 3-halo-1-azaallylic carbanions, regiospecifically generated from alpha-halogenated ketimines, with omega-iodoazides led to the regiospecific formation of omega-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308c51aff361ab9d169a2628c9fa2fb5
https://doi.org/10.1021/jo000724t
https://doi.org/10.1021/jo000724t
Publikováno v:
Tetrahedron. 56:7313-7318
The cyclization of acylated 4-amino-5-aryl-2-(trifluoromethyl)pyridines under the action of P 2 O 5 /POCl 3 smoothly afforded 3-(trifluoromethyl)benzo[ c ][1,6]naphthyridines in good yields. Intermediate aminopyridines were synthesized in a two-step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ff0c8e1ce238bcdf5cf8348d492823
https://doi.org/10.1016/s0040-4020(00)00637-2
https://doi.org/10.1016/s0040-4020(00)00637-2
Autor:
Norbert De Kimpe, Wim Aelterman
Publikováno v:
Tetrahedron. 54:2563-2574
Reaction of 1-azapentadienyl anions, generated by deprotonation of N-(2-buten-1-ylidene)-alkylamines, with 1-bromo-3-chloropropane led to the formation of N-[2-(3-chloropropyl)-3-buten-1-ylidene]alkylamines. By reaction with nucleophiles and bases, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e709e6f660ac1d8b835121a34369a38b
https://doi.org/10.1016/s0040-4020(98)00019-2
https://doi.org/10.1016/s0040-4020(98)00019-2
Publikováno v:
The Journal of Organic Chemistry. 62:5138-5143
cis-2-Alkoxy-3-aminooxolanes 4 were synthesized in a remarkably stereospecific manner by alcoholysis of alpha-chloro-gamma-((trimethylsilyl)oxy)ketimines 2, obtained by alkylation of alpha-chloroketimines 1 with 2-bromo-1-((trimethylsilyl)oxy)ethane.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8263c2cecadc3c69a47774485596d7eb
https://doi.org/10.1021/jo970410e
https://doi.org/10.1021/jo970410e
Autor:
Wim Aelterman, Norbert De Kimpe
Publikováno v:
Tetrahedron. 52:12815-12820
Manicone [(4E,6S)-(+)-4,6-dimethyl-4-octen-3-one], an alarm pheromone component of Manica ants, was synthesized by a five-step sequence starting from 2-chloro-3-pentanone. The latter α-chloro ketone was converted into the corresponding N-isopropyl k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::476d209750bc16752f61ee26e57952b3
https://doi.org/10.1016/0040-4020(96)00762-4
https://doi.org/10.1016/0040-4020(96)00762-4