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Akademický článek

Cationic liposomes bearing Bet v 1 by coiled coil-formation are hypo-allergenic and induce strong immunogenicity in mice

Autor: Hans Warmenhoven, Romain Leboux, Athanasios Bethanis, Jolinde van Strien, Adrian Logiantara, Hans van Schijndel, Lorenz Aglas, Leonie van Rijt, Bram Slütter, Alexander Kros, Wim Jiskoot, Ronald van Ree

Publikováno v: Frontiers in Allergy, Vol 3 (2023)

Although aluminum hydroxide (alum) is widely accepted and used as safe vaccine adjuvant, there is some concern about possible toxicity upon long-lasting repeated exposure during subcutaneous allergen immunotherapy (SCIT). Our objective was to evaluat

Externí odkaz: https://doaj.org/article/905c09bc6a6a4365b881e95b3b1321e6

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Akademický článek

Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model

Autor: Jolinde van Strien, Hans Warmenhoven, Adrian Logiantara, Max Makurat, Lorenz Aglas, Athanasios Bethanis, Romain Leboux, Leonie van Rijt, J. Andrew MacKay, Johannes W. van Schijndel, Gregory Schneider, René Olsthoorn, Wim Jiskoot, Ronald van Ree, Alexander Kros

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied mice

Externí odkaz: https://doaj.org/article/ee4f7a6d5ac74d13b0074cd0865161f4

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Akademický článek

Together is Better: mRNA Co‐Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co‐Delivery and Protein Expression on the Single Cell Level

Autor: Heyang Zhang, Jeroen Bussmann, Florian H. Huhnke, Joke Devoldere, An‐Katrien Minnaert, Wim Jiskoot, Friedhelm Serwane, Joachim Spatz, Magnus Röding, Stefaan C. De Smedt, Kevin Braeckmans, Katrien Remaut

Publikováno v: Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)

Abstract Liposomes can efficiently deliver messenger RNA (mRNA) into cells. When mRNA cocktails encoding different proteins are needed, a considerable challenge is to efficiently deliver all mRNAs into the cytosol of each individual cell. In this wor

Externí odkaz: https://doaj.org/article/836eb56c915b40afa530d03660979760

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Impact of Stress on the Immunogenic Potential of Adalimumab

Autor: Petteri Heljo, Maryam Ahmadi, Malthe Møhl Hugo Schack, Robert Cunningham, Anaïs Manin, Per Franklin Nielsen, Xinsheng Tian, Mark Fogg, Campbell Bunce, Dorrit Baunsgaard, Wim Jiskoot

Publikováno v: Journal of Pharmaceutical Sciences. 112:1000-1010

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61627a547278caf46856dc1d2d4ffc7b
https://doi.org/10.1016/j.xphs.2022.12.027

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Supplementary Tables 1 and 2 and Supplementary Figures 1 through 7 from Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines

Autor: Ferry Ossendorp, Wim Jiskoot, Joke Bouwstra, Naomi Benne, Eleni Maria Varypataki

Supplementary Table 1: Loading efficiencies of OVA24 and OVA17 in liposomes Supplementary fig.1: Loading of OVA17 and OVA24 in liposomes as function of adjustable initial peptide concentration Supplementary Table 2:Physicochemical properties of lipos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f444b40bccb69c88f9980adfb4ae273
https://doi.org/10.1158/2326-6066.22537610.v1

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Data from Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines

Autor: Ferry Ossendorp, Wim Jiskoot, Joke Bouwstra, Naomi Benne, Eleni Maria Varypataki

Therapeutic vaccination with synthetic long peptides (SLP) can be clinically effective against HPV-induced premalignant lesions; however, their efficiency in established malignant lesions leaves room for improvement. Here, we report the high therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9a660fefe84fe8e3507161489757a3f
https://doi.org/10.1158/2326-6066.c.6548498.v1

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Akademický článek

Cationic Nanoparticle-Based Cancer Vaccines

Autor: Jeroen Heuts, Wim Jiskoot, Ferry Ossendorp, Koen van der Maaden

Publikováno v: Pharmaceutics, Vol 13, Iss 5, p 596 (2021)

Cationic nanoparticles have been shown to be surprisingly effective as cancer vaccine vehicles in preclinical and clinical studies. Cationic nanoparticles deliver tumor-associated antigens to dendritic cells and induce immune activation, resulting in

Externí odkaz: https://doaj.org/article/d67faa7deb5647f3adf7f05d6bbcdc69

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Uptake Kinetics Of Liposomal Formulations of Differing Charge Influences Development of in Vivo Dendritic Cell Immunotherapy

Autor: Noémi Anna Nagy, Charlotte Castenmiller, Fernando Lozano Vigario, Rinske Sparrius, Toni M.M. van Capel, Aram M. de Haas, Yvette van Kooyk, Ronald van Ree, Sander W. Tas, Teunis B.H. Geijtenbeek, Wim Jiskoot, Bram Slütter, Esther C. de Jong

Publikováno v: Nagy, N A, Castenmiller, C, Vigario, F L, Sparrius, R, van Capel, T M M, de Haas, A M, van Kooyk, Y, van Ree, R, Tas, S W, Geijtenbeek, T B H, Jiskoot, W, Slütter, B & de Jong, E C 2022, ' Uptake Kinetics Of Liposomal Formulations of Differing Charge Influences Development of in Vivo Dendritic Cell Immunotherapy ', European Journal of Pharmaceutical Sciences, vol. 111, no. 4, pp. 1081-1091 . https://doi.org/10.1016/j.xphs.2022.01.022
European Journal of Pharmaceutical Sciences, 111(4), 1081-1091. Elsevier
Journal of pharmaceutical sciences, 111(4), 1081-1091. John Wiley and Sons Inc.
Journal of Pharmaceutical Sciences, 111(4), 1081-1091. ELSEVIER SCIENCE INC

Dendritic cells (DCs) control adaptive immunity and are therefore attractive for in vivo targeting to either induce immune activation or tolerance, depending on disease. Liposomes, nanoparticles comprised of a lipid bi-layer, provide a nanoplatform f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2430cd417d990b4dd9f955c9340dff4
https://doi.org/10.1016/j.xphs.2022.01.022

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Oxidation and Deamidation of Monoclonal Antibody Products: Potential Impact on Stability, Biological Activity, and Efficacy

Autor: Surbhi Gupta, Wim Jiskoot, Christian Schöneich, Anurag S. Rathore

Publikováno v: Journal of Pharmaceutical Sciences, 111(4), 903-918. ELSEVIER SCIENCE INC

The role in human health of therapeutic proteins in general, and monoclonal antibodies (mAbs) in particular, has been significant and is continuously evolving. A considerable amount of time and resources are invested first in mAb product development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0e227b93f982365f94e83031c8ddcb
https://doi.org/10.1016/j.xphs.2021.11.024

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Akademický článek

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Autor: Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz

Publikováno v: Vaccines, Vol 8, Iss 4, p 712 (2020)

Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations

Externí odkaz: https://doaj.org/article/6f84b0f9ce2b4132853060a14e99cd7c

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