Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Wim, Jiskoot"'
Autor:
Hans Warmenhoven, Romain Leboux, Athanasios Bethanis, Jolinde van Strien, Adrian Logiantara, Hans van Schijndel, Lorenz Aglas, Leonie van Rijt, Bram Slütter, Alexander Kros, Wim Jiskoot, Ronald van Ree
Publikováno v:
Frontiers in Allergy, Vol 3 (2023)
Although aluminum hydroxide (alum) is widely accepted and used as safe vaccine adjuvant, there is some concern about possible toxicity upon long-lasting repeated exposure during subcutaneous allergen immunotherapy (SCIT). Our objective was to evaluat
Externí odkaz:
https://doaj.org/article/905c09bc6a6a4365b881e95b3b1321e6
Autor:
Jolinde van Strien, Hans Warmenhoven, Adrian Logiantara, Max Makurat, Lorenz Aglas, Athanasios Bethanis, Romain Leboux, Leonie van Rijt, J. Andrew MacKay, Johannes W. van Schijndel, Gregory Schneider, René Olsthoorn, Wim Jiskoot, Ronald van Ree, Alexander Kros
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied mice
Externí odkaz:
https://doaj.org/article/ee4f7a6d5ac74d13b0074cd0865161f4
Autor:
Heyang Zhang, Jeroen Bussmann, Florian H. Huhnke, Joke Devoldere, An‐Katrien Minnaert, Wim Jiskoot, Friedhelm Serwane, Joachim Spatz, Magnus Röding, Stefaan C. De Smedt, Kevin Braeckmans, Katrien Remaut
Publikováno v:
Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)
Abstract Liposomes can efficiently deliver messenger RNA (mRNA) into cells. When mRNA cocktails encoding different proteins are needed, a considerable challenge is to efficiently deliver all mRNAs into the cytosol of each individual cell. In this wor
Externí odkaz:
https://doaj.org/article/836eb56c915b40afa530d03660979760
Autor:
Petteri Heljo, Maryam Ahmadi, Malthe Møhl Hugo Schack, Robert Cunningham, Anaïs Manin, Per Franklin Nielsen, Xinsheng Tian, Mark Fogg, Campbell Bunce, Dorrit Baunsgaard, Wim Jiskoot
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1000-1010
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61627a547278caf46856dc1d2d4ffc7b
https://doi.org/10.1016/j.xphs.2022.12.027
https://doi.org/10.1016/j.xphs.2022.12.027
Supplementary Table 1: Loading efficiencies of OVA24 and OVA17 in liposomes Supplementary fig.1: Loading of OVA17 and OVA24 in liposomes as function of adjustable initial peptide concentration Supplementary Table 2:Physicochemical properties of lipos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f444b40bccb69c88f9980adfb4ae273
https://doi.org/10.1158/2326-6066.22537610.v1
https://doi.org/10.1158/2326-6066.22537610.v1
Therapeutic vaccination with synthetic long peptides (SLP) can be clinically effective against HPV-induced premalignant lesions; however, their efficiency in established malignant lesions leaves room for improvement. Here, we report the high therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a660fefe84fe8e3507161489757a3f
https://doi.org/10.1158/2326-6066.c.6548498.v1
https://doi.org/10.1158/2326-6066.c.6548498.v1
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 596 (2021)
Cationic nanoparticles have been shown to be surprisingly effective as cancer vaccine vehicles in preclinical and clinical studies. Cationic nanoparticles deliver tumor-associated antigens to dendritic cells and induce immune activation, resulting in
Externí odkaz:
https://doaj.org/article/d67faa7deb5647f3adf7f05d6bbcdc69
Publikováno v:
Journal of Pharmaceutical Sciences, 111(4), 903-918. ELSEVIER SCIENCE INC
The role in human health of therapeutic proteins in general, and monoclonal antibodies (mAbs) in particular, has been significant and is continuously evolving. A considerable amount of time and resources are invested first in mAb product development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0e227b93f982365f94e83031c8ddcb
https://doi.org/10.1016/j.xphs.2021.11.024
https://doi.org/10.1016/j.xphs.2021.11.024
Autor:
Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz
Publikováno v:
Vaccines, Vol 8, Iss 4, p 712 (2020)
Currently, batch release of toxoid vaccines, such as diphtheria and tetanus toxoid, requires animal tests to confirm safety and immunogenicity. Efforts are being made to replace these tests with in vitro assays in a consistency approach. Limitations
Externí odkaz:
https://doaj.org/article/6f84b0f9ce2b4132853060a14e99cd7c
Autor:
Peter C. Soema, Sietske K. Rosendahl Huber, Geert-Jan Willems, Ronald Jacobi, Marion Hendriks, Ernst Soethout, Wim Jiskoot, Jørgen de Jonge, Josine van Beek, Gideon F. A. Kersten, Jean-Pierre Amorij
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Influenza peptide antigens coding for conserved T cell epitopes have the capacity to induce cross-protective influenza-specific immunity. Short peptide antigens used as a vaccine, however, often show poor immunogenicity. In this study, we demonstrate
Externí odkaz:
https://doaj.org/article/688c54d00d8745a7ae75b0cdd6a09d4a