Výsledky vyhledávání - "Wiltrud Haass"

Akademický článek

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.

Autor: Wiltrud Haaß, Helga Kleiner, Christel Weiß, Claudia Haferlach, Brigitte Schlegelberger, Martin C Müller, Rüdiger Hehlmann, Wolf-Karsten Hofmann, Alice Fabarius, Wolfgang Seifarth, Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung, German CML Study Group

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129648 (2015)

Unbalanced (major route) additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid leukemia (CML) indicate an increased risk of progression and shorter survival. Moreover, newly arising ACA under imatinib treatment and clonal evolution

Externí odkaz: https://doaj.org/article/f121bb6eca144f35b1cf7854cf9ad6dc

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Akademický článek

Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay.

Autor: Wiltrud Haaß, Helga Kleiner, Martin C Müller, Wolf-Karsten Hofmann, Alice Fabarius, Wolfgang Seifarth

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133769 (2015)

ESPL1/Separase, an endopeptidase, is required for centrosome duplication and separation of sister-chromatides in anaphase of mitosis. Overexpression and deregulated proteolytic activity of Separase as frequently observed in human cancers is associate

Externí odkaz: https://doaj.org/article/0ae70782c5b54ec98a47e9f9b5b718c0

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Akademický článek

The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib.

Autor: Wiltrud Haaß, Michael Stehle, Stefanie Nittka, Michelle Giehl, Petra Schrotz-King, Alice Fabarius, Wolf-Karsten Hofmann, Wolfgang Seifarth

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42863 (2012)

Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an ane

Externí odkaz: https://doaj.org/article/9717e87e5e1a4a74b66d1e2ec32705d1

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Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability

Autor: Wolf-Karsten Hofmann, Maximillian Mossner, Daniel Nowak, Alice Fabarius, Christiane Schumann, Torsten J. Schulze, Wiltrud Haass, Henning D. Popp, Verena Nowak, Stefan Klein, Wolfgang Seifarth, Florian Nolte, Michelle Giehl

Publikováno v: Annals of Hematology. 92:1325-1333

Centrosomes play important roles in the maintenance of genetic stability and centrosomal aberrations are a hallmark of cancer. Deregulation of centriole duplication leads to supernumerary centrosomes, sister chromatid missegregation and could result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf5bbdd40e5d828cd998c57cba9f9a3
https://doi.org/10.1007/s00277-013-1772-7

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Urine from current smokers induces centrosome aberrations and spindle defects in vitro in nonmalignant human cell lines

Autor: Maurice Stephan Michel, Wolf-Karsten Hofmann, Wolfgang Seifarth, Lutz Trojan, Wiltrud Haass, Michelle Giehl, Ute Gabriel, Alice Fabarius

Publikováno v: Cancer Genetics and Cytogenetics. 203:253-262

Tobacco smoke containing numerous derived chemical carcinogens is the main risk factor for urothelial carcinoma. These carcinogens can induce DNA damage leading to chromosomal instability, which plays a fundamental role in urothelial carcinogenesis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65299cab4df9f1637ccbc03f4b1fe5eb
https://doi.org/10.1016/j.cancergencyto.2010.07.135

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Phenylacetic Acid and Arterial Vascular Properties in Patients with Chronic Kidney Disease Stage 5 on Hemodialysis Therapy

Autor: Martin Tepel, Antje Wittstock, Sukhbaatar Suvd-Erdene, Joachim Jankowski, Alexandra Scholze, Wiltrud Haass, Vera Jankowski, Lars Henning, Walter Zidek

Publikováno v: Scholze, A, Jankowski, V, Henning, L, Haass, W, Wittstock, A, Suvd-Erdene, S, Zidek, W, Tepel, M & Jankowski, J 2007, ' Phenylacetic acid and arterial vascular properties in patients with chronic kidney disease stage 5 on hemodialysis therapy ', NEPHRON PHYSIOLOGY, vol. 107, no. 1, pp. c1-6 . https://doi.org/10.1159/000105137

Background: Phenylacetic acid (PAA) is a recently described uremic toxin that inhibits inducible nitric oxide synthase expression and plasma membrane calcium ATPase and may therefore also be involved in remodeling of arteries. Such vascular effects h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7278f5a3562aa1f3a714b1e904c4bd44
https://doi.org/10.1159/000105137

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Consuming fructose-sweetened beverages increases body adiposity in mice

Autor: Frank Dombrowski, Michael Ristow, Wiltrud Haass, Andrea R. Nawrocki, Hella Jürgens, Matthias H. Tschöp, Philipp E. Scherer, Jochen Spranger, Tamara R. Castañeda, HG Joost, Bärbel Otto, Annette Schürmann, Peter J. Havel, Corinna Koebnick

Publikováno v: Jürgens, H; Haass, W; Castañeda, TR; Schürmann, A; Koebnick, C; Dombrowski, F; et al.(2005). Consuming fructose-sweetened beverages increases body adiposity in mice. Obesity Research, 13(7), 1145-1156. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3fw8f43b
Scopus-Elsevier
Obesity research, vol 13, iss 7

Author(s): Jurgens, Hella; Haass, Wiltrud; Castaneda, Tamara R; Schurmann, Annette; Koebnick, Corinna; Dombrowski, Frank; Otto, Barbel; Nawrocki, Andrea R; Scherer, Philipp E; Spranger, Jochen; Ristow, Michael; Joost, Hans-Georg; Havel, Peter J; Tsch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e572bf5f21572002e75d16919e4486
http://www.escholarship.org/uc/item/3fw8f43b

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Centrosome Aberrations in Bone Marrow Cells From Patients with Myelodysplastic Syndromes Correlate with Chromosomal Instability

Autor: Verena Nowak, Wolf-Karsten Hofmann, Alice Fabarius, Wiltrud Haass, Torsten J. Schulze, Michelle Giehl, Florian Nolte, Maximilian Mossner, Wolfgang Seifarth, Stefan Klein, Christiane Schumann, Daniel Nowak

Publikováno v: Blood. 120:3839-3839

Abstract 3839 Introduction: Centrosomes play important roles in maintenance of genetic stability and centrosomal aberrations are a common hallmark of cancer. Deregulation of centriole duplication during the cell cycle leads to supernumerary centrosom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35aa612e32c1c94d9a6a28ec7c50dcca
https://doi.org/10.1182/blood.v120.21.3839.3839

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The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib

Autor: Alice Fabarius, Wiltrud Haaß, Michelle Giehl, Wolf-Karsten Hofmann, Petra Schrotz-King, Stefanie Nittka, Wolfgang Seifarth, Michael Stehle

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42863 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6212f3eac592bc0111fe4ea50aff438c
https://doi.org/10.1371/journal.pone.0042863

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