Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Wilton B. Williams"'
Publikováno v:
Viruses, Vol 16, Iss 7, p 1014 (2024)
We recently demonstrated that Simian–HIV (SHIV)-infected neonate rhesus macaques (RMs) generated heterologous HIV-1 neutralizing antibodies (NAbs) with broadly-NAb (bNAb) characteristics at a higher frequency compared with their corresponding dam.
Externí odkaz:
https://doaj.org/article/12cfb65587624ee0bc0ebbb0487de846
Autor:
Bhavna Hora, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, Andrew N. Macintyre, Aria Arus-Altuz, Shuyi Wang, Ajay Singh, Chengyan Zhao, Nicole De Naeyer, Todd DeMarco, Cindy Kuykendall, Thaddeus Gurley, Kevin O. Saunders, Thomas Denny, M. Anthony Moody, John Misamore, Mark G. Lewis, Kevin Wiehe, Derek W. Cain, David C. Montefiori, George M. Shaw, Wilton B. Williams
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112255- (2023)
Summary: Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for t
Externí odkaz:
https://doaj.org/article/7dce7418af584710aa80977788fdbcd6
Autor:
Qifeng Han, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, Regina W. Edwards, Guido Ferrari, Olaf Mueller, Xiaoying Shen, Kevin J. Wiehe, Steven Reed, Christopher B. Fox, Wes Rountree, Nathan A. Vandergrift, Yunfei Wang, Laura L. Sutherland, Sampa Santra, M. Anthony Moody, Sallie R. Permar, Georgia D. Tomaras, Mark G. Lewis, Koen K.A. Van Rompay, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1553-1569.e6 (2020)
Summary: HIV-1-infected infants develop broadly neutralizing antibodies (bnAbs) more rapidly than adults, suggesting differences in the neonatal versus adult responses to the HIV-1 envelope (Env). Here, trimeric forms of HIV-1 Env immunogens elicit i
Externí odkaz:
https://doaj.org/article/e0ebd789a52f48e3b4e0a32d2972f0a6
Autor:
Wilton B. Williams, Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M. Anthony Moody, Hua-Xin Liao, S. Munir Alam, Thomas B. Kepler, Akshaya Ramesh, Kevin Wiehe, James A. Holland, Todd Bradley, Nathan Vandergrift, Kevin O. Saunders, Robert Parks, Andrew Foulger, Shi-Mao Xia, Mattia Bonsignori, David C. Montefiori, Mark Louder, Amanda Eaton, Sampa Santra, Richard Scearce, Laura Sutherland, Amanda Newman, Hilary Bouton-Verville, Cindy Bowman, Howard Bomze, Feng Gao, Dawn J. Marshall, John F. Whitesides, Xiaoyan Nie, Garnett Kelsoe, Steven G. Reed, Christopher B. Fox, Kim Clary, Marguerite Koutsoukos, David Franco, John R. Mascola, Stephen C. Harrison, Barton F. Haynes, Laurent Verkoczy
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnA
Externí odkaz:
https://doaj.org/article/69f91741f8e94cd5827c2664a8377d65
Autor:
Kevin O. Saunders, James Counts, Victoria Stalls, Robert Edwards, Kartik Manne, Xiaozhi Lu, Bhishem Thakur, Katayoun Mansouri, Yue Chen, Rob Parks, Maggie Barr, Laura Sutherland, Joena Bal, Nicholas Havill, Haiyan Chen, Emily Machiele, Nolan Jamieson, Bhavna Hora, Megan Kopp, Katarzyna Janowska, Kara Anasti, Chuancang Jiang, Sravani Venkatayogi, Amanda Eaton, Rory Henderson, Christopher Barbosa, S. Munir Alam, Sampa Santra, Drew Weissman, M. Anthony Moody, Derek W. Cain, Ying Tam, Mark Lewis, Wilton B. Williams, Kevin Wiehe, David Montefiori, Priyamvada Acharya, Barton F. Haynes
SUMMARYThe CD4 binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for many reasons, including the CD4bs is occlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4f4f461e186c69e94297d7dd514865
https://doi.org/10.2139/ssrn.4414883
https://doi.org/10.2139/ssrn.4414883
Autor:
Kevin Wiehe, Kevin O. Saunders, Victoria Stalls, Derek W. Cain, Sravani Venkatayogi, Joshua S. Martin Beem, Madison Berry, Tyler Evangelous, Rory Henderson, Bhavna Hora, Shi-Mao Xia, Chuancang Jiang, Amanda Newman, Cindy Bowman, Xiaozhi Lu, Mary E. Bryan, Joena Bal, Aja Sanzone, Haiyan Chen, Amanda Eaton, Mark A. Tomai, Christopher B. Fox, Ying Tam, Christopher Barbosa, Mattia Bonsignori, Hiromi Muramatsu, S. Munir Alam, David Montefiori, Wilton B. Williams, Norbert Pardi, Ming Tian, Drew Weissman, Frederick W. Alt, Priyamvada Acharya, Barton F. Haynes
A major goal of HIV-1 vaccine development is induction of broadly neutralizing antibodies (bnAbs). While success has been achieved in initiating bnAb B cell lineages, design of boosting immunogens that select for bnAb B cell receptors with improbable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ec35f9fb922ae004a0cb0bdff7183c8
https://doi.org/10.1101/2022.11.11.516143
https://doi.org/10.1101/2022.11.11.516143
Autor:
Kevin O. Saunders, Robert J. Edwards, Kedamawit Tilahun, Kartik Manne, Xiaozhi Lu, Derek W. Cain, Kevin Wiehe, Wilton B. Williams, Katayoun Mansouri, Giovanna E. Hernandez, Laura Sutherland, Richard Scearce, Robert Parks, Maggie Barr, Todd DeMarco, Chloe M. Eater, Amanda Eaton, Georgeanna Morton, Benjamin Mildenberg, Yunfei Wang, R. Wes Rountree, Mark A. Tomai, Christopher B. Fox, M. Anthony Moody, S. Munir Alam, Sampa Santra, Mark G. Lewis, Thomas N. Denny, George M. Shaw, David C. Montefiori, Priyamvada Acharya, Barton F. Haynes
Publikováno v:
Sci Transl Med
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb) response, yet vaccine-mediated induction of such a response in primates remains a challenge. We found that a stabilized HIV-1 CH505 envelope (Env) trimer fo
Autor:
Megan Kopp, S. Munir Alam, Sophie M. C. Gobeil, R Parks, Priyamvada Acharya, Zekun Mu, Rory Henderson, Gregory D. Sempowski, Robert J. Edwards, Kartik Manne, Dapeng Li, Kevin O. Saunders, Jordan Sprenz, Katarzyna Janowska, Wilton B. Williams, Margaret Deyton, Xiaozhi Lu, Brian E. Watts, Barton F. Haynes, Thomas H. Oguin, Victoria Stalls, Katayoun Mansouri, David C. Montefiori
Publikováno v:
bioRxiv
Nature structural & molecular biology
Nature Structural & Molecular Biology
Nature structural & molecular biology
Nature Structural & Molecular Biology
The impact of COVID-19 and the urgency to develop a vaccine against the SARS-CoV-2 virus cannot be overstated. The viral fusion spike (S) protein ectodomain is the primary target for vaccine development. Here we report an unexpected cold sensitivity
Autor:
Barton F. Haynes, Olaf Mueller, Robert Parks, Nathan Vandergrift, Sallie R. Permar, Steven G. Reed, David C. Montefiori, Christopher B. Fox, Sampa Santra, Guido Ferrari, Regina W. Edwards, Todd Bradley, Wilton B. Williams, Wes Rountree, Derek W. Cain, M. Anthony Moody, Xiaoying Shen, Koen K. A. Van Rompay, Laura L. Sutherland, Yunfei Wang, Kevin O. Saunders, Kevin Wiehe, Qifeng Han, Georgia D. Tomaras, Mark G. Lewis
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1553-1569.e6 (2020)
Cell reports
Cell reports
SUMMARY HIV-1-infected infants develop broadly neutralizing antibodies (bnAbs) more rapidly than adults, suggesting differences in the neonatal versus adult responses to the HIV-1 envelope (Env). Here, trimeric forms of HIV-1 Env immunogens elicit in
Autor:
Christopher Barbosa, Amanda Newman, Sravani Venkatayogi, Shi-Mao Xia, Rory Henderson, Wilton B. Williams, Qifeng Han, Barton F. Haynes, Robert J. Edwards, Robert Parks, Kevin O. Saunders, Kevin Wiehe, Mattia Bonsignori, Katayoun Mansouri, Norbert Pardi, Xiaozhi Lu, David C. Montefiori, Tyler Evangelous, Zekun Mu, Wes Rountree, Diana Martik, Yunfei Wang, Drew Weissman, Derek W. Cain, Ying Tam, S. Munir Alam
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
SUMMARYThe success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope (Env) trimer protein nanoparticles are superior immunogens compared to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e41b1f59f8d8926f0862f1c8d12ac5
https://doi.org/10.1101/2021.08.09.455714
https://doi.org/10.1101/2021.08.09.455714